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Biomedical subjects

F Simeone

Publications and source records attributed to F Simeone.

31 records · Page 2Linked to original sources
PubMed1986

Cervical radiculopathy. A review.

This paper is a review of current information on cervical radiculopathy. The focus is on the natural history of the process, the accuracy of diagnostic tests to determine etiology, the differential diagnosis involved, and the surgical tactics available. The most important conclusions are the criteria for patient selection for surgery and a statistical demonstration of the adequacy of both the anterior and the posterior approaches for decompression of the cervical nerve root.

Humans↗
PubMed1983

Recovery of vision following treatment of the ocular ischemic syndrome.

A case of the ocular ischemic syndrome secondary to carotid artery occlusive disease responded to comprehensive treatment. The mode of presentation of the ocular ischemic syndrome is reviewed and the differential diagnosis discussed. Fluorescein angiography and electroretinography are shown to be useful adjuncts in the diagnosis and in assessing treatment. Emphasis is placed on early aggressive ocular therapy aimed at lowering intraocular pressure, maintaining an open anterior chamber angle, and reducing the ischemic drive for iris neovascularization in combination with carotid artery bypass surgery. The potential for success with this comprehensive approach is illustrated.

Arterial Occlusive Diseases↗
PubMed1976

Effect of cardiac arrest on cerebral circulation. An experimental investigation.

The effect of 2 to 15 min of cardiac arrest on cerebral circulation was investigated in dogs and Rhesus monkeys. When circulatory arrest lasted longer than 5 minutes, angiographic changes of the no-reflow phenomenon were observed between 3 and 4 h after resuscitation in dogs but not in monkeys. These findings were (1) marked prolongation of the arterial phase in both intracranial and extracranial arteries; followed by (2) occasional evidence of dilatation of the proximal intracranial arteries with non-filling of the distal intracranial arteries; and (3) faint demonstration of the venous phase. Carbon black perfusion results were (1) diffuse lack of perfusion at the arteriolar-capillary level and (2) multifocal areas of filling defects. Regional cortical blood flow measurement in monkeys disclosed a significant decrease in flow starting from 3 h after re-establishment of circulation for those in which longer than 5 min of arrest was induced.

Animals↗
PubMedDate not supplied

Attenuation of ischemic brain edema by pentobarbital after carotid ligation in the gerbil.

The efficacy of pentobarbital in the treatment of ischemic cerebral edema was evaluated in 160 gerbils. Animals underwent carotid ligation under ether or pentobarbital (50 mg/kg) anesthesia. The pentobarbital anesthetized group received an additional dose of 30 mg/kg 4 h after ligation. Animals were evaluated for neurologic deficit at 4 and 8 h post-ligation, then sacrificed. Water content of each hemisphere and swelling percentage were calculated from the wet and dry weights of the hemispheres. Swelling percentage in animals anesthetized with ether was 6.374 +/- 0.89 SE, whereas gerbils who underwent sham carotid ligation showed a negligible (0.491 +/- 0.15) swelling percentage (p less than 0.01). Pentobarbital animals had a swelling percentage of 3.359 +/- 0.68. This represents a significant edema reduction compared to ether-anesthetized animals (p less than 0.01). Neurologic deficit was decreased by 56.7% (17/60 vs 30/60) in pentobarbital animals compared with ether animals (p less than 0.025). Mortality at 8 hours was reduced by 75% (2/60 vs 8/60) in pentobarbital animals (p less than 0.05).

Animals↗
PubMedDate not supplied

[Autoantibodies against oxidised low density lipoproteins in patients with coronary disease].

OBJECTIVES: Evidence has been obtained indicating that oxidation of low-density lipoproteins (LDL) plays a relevant role in the pathogenesis of atherosclerosis and it has been proposed that, due to the antigenic properties of oxidized LDL, the anti-oxLDL antibody titre could represent a useful index of in vivo LDL oxidation. METHODS: Sixty-nine control subjects and 64 patients scheduled for selective coronary revascularization were investigated before surgery. RESULTS: The coronary disease patients had a higher level of total plasma cholesterol, LDL cholesterol and triglycerides, and a lower level of HDL cholesterol. Plasma anti-oxLDL antibody titre was measured as the ratio of antibody binding to CuSO4-oxidised LDL versus native LDL. The antibody ratio was higher in coronary patients as compared with control subjects (1.56 +/- 0.5 vs 1.0 +/- 0.3, p < 0.01). A ratio higher than 1.34 (mean of controls +/- one standard deviation) was present in 60% of the coronary patients. Subclass analysis indicated that the presence of diabetes mellitus and hypercholesterolaemia (but not of hypertension, generalized arteriosclerosis, myocardial infarction and cigarette smoking) increased the anti-oxLDL antibody ratio to 1.72 +/- 0.4 and 1.68 +/- 0.3 respectively. CONCLUSION: The results obtained indicate that a) a high titre of anti-oxLDL antibodies is present in plasma of patients with coronary atherosclerosis, b) in these patients LDL oxidation takes place in vivo and probably plays a critical role in the development and progression of atherosclerosis.

Adult↗