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Biomedical subjects

F Sirigu

Publications and source records attributed to F Sirigu.

At least 19 recordsLinked to original sources
PubMed1997

Relationship between Helicobacter pylori infection and gastric follicular hyperplasia. A retrospective study.

BACKGROUND: The occurrence of lymphoid follicles in the gastric mucosa was recently considered to be acquired in respose to infection by Helicobacter pylori. METHODS: In order to investigate whether there is any correlation between follicular hyperplasia and Helicobacter pylori colonization, a morphological study was performed in antral biopsy specimens from 267 patients with H. pylori-associated gastritis, and from 312 subjects with histological evidence of chronic gastritis, but without H. pylori colonization. RESULTS: Follicular hyperplasia was observed in 33 (12.3%) specimens with H. pylori-associated gastritis, and in 56 (9%) samples from non-infected group (p=ns). In both H. pylori-positive and H. pylori-negative specimens lymphoid follicular hyperplasia showed a significant correlation with the degree of the gastritis. In these two groups the prevalence of follicular hyperplasia was also significantly higher in the elderly. CONCLUSIONS: On the basis of these results, we were unable to find any significant correlation between H. pylori infection and occurrence of lymphoid follicular hyperplasia. The appearance of organized follicular structures in the gastric mucosa seems to be acquired in response to multiple events, and not exclusively in consequence of the colonization by Helicobacter pylori.

Journal Article↗
PubMed1993

Effect of Helicobacter pylori colonization on quantitative distribution of antral G-cells in apparently healthy subjects and in duodenal ulcer patients. A morphometric study.

To investigate whether antral colonization by Helicobacter pylori (Hp) modifies gastrin-cell population, the number of G-cells was evaluated in antral biopsy specimens from 22 apparently healthy subjects and from 48 duodenal ulcer patients using a morphometric method. The level of serum immunoreactive gastrin in a sample of fasting serum obtained at the time of biopsy was also measured. In healthy subjects the G-cell count (evaluated according to G/I index) and the serum gastrin levels were not significantly different than those found in duodenal ulcer patients. When the antral colonization by Hp was assessed, we found that, both controls and duodenal ulcer Hp-positive patients had a mean G-cell count and fasting serum gastrin levels not significantly higher than in patients without Hp.

Adult↗
PubMed1993

Peptidergic (VIP) nerves in normal human pancreas and in pancreatitis: an immunohistochemical study.

Vasoactive intestinal polypeptide was demonstrated in the nerves of the human normal pancreas and in pancreatitis by light microscope immunohistochemical technique. In specimens of normal pancreas, vasoactive intestinal polypeptide-immunoreactive neuronal cells were present in the autonomic ganglia. These ganglia were found to receive an abundant supply of vasoactive intestinal polypeptide-positive fibre plexuses. Immunoreactive nerve fibres were seen to run in the stroma, in association with secretory acini, ducts and blood vessels. Vasoactive intestinal polypeptide-positive fibres were also seen close to the Langerhans' islets, but no vasoactive intestinal polypeptide-like immunoreactivity was observed in the endocrine cells. In specimens from patients affected by pancreatitis, even in lesioned regions, immunoreactive elements were extremely scarce.

Connective Tissue↗
PubMed1991

[The duodenoscopic picture in adult celiac disease].

The duodenal endoscopic pictures were studied in 12 adult coeliacs patients, aged between 18 and 76 years, mean age 41.9 +/- 17.6 yrs. All patients carried out D-xylose absorption test, antigliadin IgA antibodies and distal duodenum biopsy. The more frequent endoscopic picture was the disappearance of Kerckring's folds; nevertheless in 5 patients the loss of Kerckring's folds was associated with duodenal mucosa irregularity. We believe that in future the knowledge of this new endoscopic picture will be useful in coeliac's disease diagnosis.

Adolescent↗
PubMed1990

Morphological study of the gastric antral mucosa colonized by campylobacter pylori.

Antral biopsies from 56 patients who underwent gastroscopy for upper gastrointestinal symptoms were studied by transmission electron microscopy. Campylobacter pylori was demonstrated in specimens from 39 patients. The bacteria were present in 3 of the 8 normal specimens and in 36 of the 48 cases with chronic gastritis. Electron microscopy showed that organisms were located deep the mucous layer in intimate relation with the luminar surface of the antral epithelium. No ultra-structural evidence was found to suggest bacterial invasion of the mucosa or phagocitic ingestion by neutrophils. Our results indicate a close correlation between active inflammation and Campylobacter pylori.

Adult↗
PubMed1990

[The role of Campylobacter pylori in gastroduodenal pathology].

Biopsy specimens from the gastric antral mucosa of 194 patients with upper gastrointestinal symptoms were studied with the Warthin-Starry silver stain to demonstrate the presence of Campylobacter Pylori (CP). Of these patients, 44 had peptic ulcer visible on endoscopic investigation. Spiral bacteria were detected in 70 out of 75 specimens with histologically active gastritis (93%), in 34 of 54 specimens with inactive form of gastritis (63%) and in 26 of 65 specimens without morphological changes (40%). Of 44 patients found to have gastric or duodenal ulcers, 33 also had bacteria. No significant differences between patients with endoscopically visible peptic ulcer and those without ulcer were seen. Our results indicate a close relationship between the active form of chronic gastritis and Campylobacter; however they do not show a definite association with peptic ulcer.

Biopsy↗
PubMed1986

A case of classical Kaposi's sarcoma in B-cell chronic lymphocytic leukemia (B-CLL).

We report a case of classical Kaposi's sarcoma (KS) in a patient affected by B-cell chronic lymphocytic leukemia for 2 years and who had not received any antiblastic treatment. At the ultrastructural analysis the leukemic cell showed rather immature features, and the immunologic phenotype (absence of detectable cytoplasmic Ig, and expression only of the DR, B2 and IgD lambda molecules on the surface membrane) proved its intermediate level of maturity, its monoclonality and relative rarity. The patient presented a complex immunologic deficiency, revealed not only by the monoclonality of the B lymphocytes and their low degree of maturity, but also by the almost total absence of T helper lymphocytes, by the high reduction in NK activity, by the very scarce proliferative response to the polyclonal mitogens PHA, ConA and PWM, and by a complete anergy to the skin test of delayed reactivity. The search for antibodies against the viruses EBV, CMV, HTLV-I and HTLV-III in the serum was negative. At the HLA typing, the patient was DR5, as are most classical KS and/or B-CLL patients. The data are discussed in relation to documented non-casual association between B-CLL and KS. We stress that immunosuppression may play an important role in the pathogenesis of both diseases and the possibility of their being conditioned by common genetic HLA-associated factors of predisposition.

Aged↗
PubMed1976

Renal histologic and ultrastructural findings in psychogenic polydipsia and diabetes insipidus.

The renal biopsies of 15 patients affected by polydipsia syndromes were examined under light and electron microscopes. The authors contend that the observed renal lesions (dilatation of the glomerular loops, tubular hypertrophy and vacuolization, and basal membrane swelling) are the morphologic result of tubular hyperfunction in the service of ion reabsorption. This, in turn, is secondary to the increased GFR.

Animals↗