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Biomedical subjects

F Sirigu

Publications and source records attributed to F Sirigu.

48 records · Page 3Linked to original sources
PubMedDate not supplied

Carcinoma of the thyroid gland, adenoma of the adrenal cortex and peptic ulcer: an unreported association.

A 39-year-old man, operated on for duodenal ulcer, was found to have a papillary carcinoma of the thyroid, an aldosterone-producing adenoma of the adrenal cortex, and a recurrence of a peptic ulcer. The probable coincidental occurrence of these diseases in this patient is suggested. Nevertheless, careful investigation of the other endocrine glands in patients with endocrine tumors is recommended.

Adenoma↗
PubMedDate not supplied

Intestinal metaplasia of the gastric mucosa: a study of its incidence in various disease states.

The incidence of intestinal metaplasia (IM) was studied in 159 specimens from gastric mucosa. Rare in histologically normal specimens (4%), the IM showed the highest incidence in patients with gastric carcinoma (75%). Intermediate values were observed in chronic atrophic gastritis (25%) and peptic ulcer (21%). Histochemical data shows that type complete-IM was most common in benign conditions; type incomplete-IM and particularly subtype secreting sulphomucins revealed a higher frequence in the mucosa bordering carcinomas.

Adult↗
PubMedDate not supplied

[Tissue carcinoembryonic antigen in normal conditions and neoplastic pathology of the colorectum].

Using an immunohistochemical method, carcinoembryonic antigen (CEA) was evaluated in bioptic specimens from 12 colorectal carcinomas, 32 neoplastic polyps and from 12 preparations of normal rectocolonic mucosa. CEA was demonstrated in 7/12 samples of normal mucosa, always localized on the apical pole of the columnar cells. In carcinomatous specimens CEA was found in 11/12 biopsies and showed a localization predominantly intracytoplasmatic or in the surrounding stroma. In 8/12 tumor specimens tested, the histologically normal mucosa bordering the carcinoma exhibited a slight staining for CEA on the apical surface of the glandular cells. Specimens from 27/32 polyps biopsied appeared to contain CEA on the apical pole of the glandular cells. These results confirm that CEA is a normal constituent of the human adult rectocolonic mucosa; the difference in CEA content between benign and malignant mucosa is very likely quantitative rather than qualitative. No indications on the prognosis of the polyps could be obtained from this study.

Adult↗
PubMedDate not supplied

Mucin histochemistry in Barrett's esophagus.

Specimens from twelve patients with Barrett's esophagus and four additional cases of esophageal carcinoma who had Barrett's epithelium were histologically and by mucin histochemistry examined. Specialized epithelium was observed in 10/12 non cancerous patients. In 9 of these either gastric-fundic or junctional epithelium were seen. All patients with carcinoma had evidence of specialized epithelium. Sulphated mucins were preponderant in biopsies from 7 of the 9 patients with dysplasia either alone or associated with carcinoma. In all 5 specimens with specialized epithelium but without dysplasia or carcinoma, sialomucins were predominant.

Adult↗
PubMedDate not supplied

[Manometric evaluation of esophageal motor activity during diabetes mellitus].

Intraluminal manometry was used to assess the motor activity of the oesophagus and upper (UES) and low (LES) oesophageal sphincter in 10 patients, 5 female and 5 male, average age 35.9 range 17-50, suffering from insulin-dependent diabetes mellitus. Non-invasive cardiovascular tests were also performed to evaluate autonomous neuropathy together with control tests of glyco-metabolic compensation (fructosamine and HbA1c). An increase in the basic tone of the UES was observed in 8 patients while in 3 this was associated with its incomplete release. Five patients evidenced aspecific motor disturbance such as spontaneous motor activity characterised by repetitive segmentary waves at times with biphasic appearance. IOS activity was within normal limits. It is considered that these disturbances may be attributable to the autonomous neuropathy that often complicates diabetes mellitus and that oesophageal motor disturbance, albeit aspecific, should be considered an early sign of autonomous neuropathy. It is therefore though that manometric oesophageal study may be considered a useful investigative tool for early evidencing of disturbances linked to autonomous neuropathy.

Adolescent↗
PubMedDate not supplied

[Gastric transit of a radiolabelled liquid meal in a group of patients with insulin-dependent diabetes mellitus].

The functional alterations in the digestive tract observable during diabetes mellitus are frequent albeit often asymptomatic. They affect several different districts and are still not clearly defined aetiopathogenetically. It was therefore decided to evaluate the gastric transit times of a balanced liquid meal labelled with 99-Tc-colloidal sulphide in a group of patients suffering from insulin-dependent diabetes and in a group of 10 controls. The anatomical integrity of the oesophago-gastro-duodenal tract has been evaluated by endoscopy and histology. Transit times (T/2) proved significantly increased in diabetics (92.38 +/- 33.397 minutes) compared to the controls (48.63 +/- 16.423 minutes), p 0.001. No correlation was observed between gastric transit times, duration of the diabetic disease, degree of glyco-metabolic compensation and presence of autonomous neuropathy.

Adult↗
PubMedDate not supplied

Helicobacter pylori in Barrett's esophagus and in normal or inflamed esophageal mucosa: a retrospective study.

To investigate on the presence and significance of Helicobacter pylori (Hp) in Barrett's mucosa, esophageal biopsy specimens from 34 patients with columnar-lined epithelium were retrospectively examined. The incidence of colonization was compared with that observed in a control group of 76 subjects with normal esophageal mucosa or moderate esophagitis. Three of the 34 Barrett's specimens were Hp-positive and only 1 of these showed evidence of inflamed mucosa (p = NS). We do not find in this study any evidence to support the existence of association between Hp and Barrett's esophagus or esophageal inflammation. The presence of Hp in antral mucosa of all positive cases suggest the possibility that esophageal colonisation might merely be a consequence of reflux from the gastric antrum.

Adult↗
PubMedDate not supplied

Helicobacter pylori and intestinal metaplasia in antral mucosa. A study on their correlation.

To investigate the possible relation between Helicobacter pylori (HP) colonization and incidence of intestinal metaplasia (IM), antral biopsy specimens from a total of 263 subjects (167 had chronic gastritis, 12 gastric cancer, and 84 no histological changes) were examined. IM was observed in 27.7% of the HP positive specimens and in 18.3% of the HP negative biopsies (p = NS). Histochemical characterization of mucins showed that the percentage of HP colonization was not significantly different within various subtypes of IM. We do not find in this study any evidence to support the existence of a pathogenetic role of HP on the morphogenesis of IM in antral mucosa.

Adult↗
PubMedDate not supplied

[The relationship between dietary intake of vitamin A and risk of gastrointestinal neoplasia].

A study on dietary intake of retinol and beta-carotene was conducted in 51 patients affected by gastric (23 cases) and colorectal (28 cases) carcinoma, considering the period preceding the onset of their illness. In all patients were measured serum retinol levels. The data were compared with those in 44 control subjects. Mean values of retinol and beta-carotene intake in the two groups showed not significant differences. The mean serum levels of retinol were similar in controls and in cancer patients (68.1 and 66.8 micrograms/dl, respectively). Our data fail to confirm previous observations about relationship between alimentary intake of retinol and beta-carotene and risk of gastrointestinal cancer.

Adult↗
PubMedDate not supplied

A retrospective study on the incidence of lymphocytic gastritis in patients with Helicobacter pylori infection.

To investigate the relationship between lymphocytic gastritis and H. pylori infection, antral biopsy specimens from 162 patients with histological evidence of H. pylori infection, and from 177 subjects without colonization were retrospectively examined. Among patients with antral colonization, lymphocytic gastritis was identified in 8 cases (4.9%). Lymphocytic gastritis was not detected in specimens without H. pylori infection. Quantitation of the epithelial lymphocytic infiltration was carried out in all specimens and showed that cases with lymphocytic gastritis had a mean of 35.3 lymphocytes per 100 epithelial cells, compared with a mean of 2.6 and 2.4 respectively in chronic gastritis and normal mucosa. Among the 331 patients without lymphocytic gastritis, specimens colonized by H. pylori had a mean of epithelial lymphocyte counts significantly higher than those observed in both chronic gastritis and normal mucosa. These findings show a positive correlation between antral colonization by H. pylori and occurrence of lymphocytic gastritis, and suggest that the bacteria may have an important role in the induction of such particular form of antral inflammation.

Adult↗