[Mesonitrophenylhydrazones of vicinal triketones with potential anthelmintic activity].
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
F Sparatore
Publications and source records attributed to F Sparatore.
[Preparation of 1-lupinylamino-4-methylthioxanthone with potential antileukemic and antischistosomal activity].
Explore the source record for details and available documents.
Antineoplastic Agents↗
[Dialkylaminoalkylbenzimidazoles of pharmacological importance. IV].
In order to improve the analgesic and antiarrhythmic activities of 1-dialkylaminoalkyl-2-benzotriazolylmethylbenzimidazoles previously described, forty derivatives with a chlorine, trifluoromethyl, acetyl or nitrogroup in 5 position were prepared.
Analgesics↗
[Preparation of N,N'-diguanyl-tetrahydro and hexahydropyridazine and of tetra and hexahydro-pyridazino-dihydrotriazolic derivatives of pharmacological interest].
Explore the source record for details and available documents.
Cyclization↗
[N-lupinylarylamines and N-aminoalkyl-m-trifluoromethylanilines of pharmacological and microbiological interest].
Explore the source record for details and available documents.
Amines↗
[Research on heterocyclic hepta-atomic azotates of pharmacological interest. Preparation of some dialkylaminoalkyl-dibenzotriazepines].
Explore the source record for details and available documents.
Alkylation↗
[Simple molecular analogs of anti-inflammatory 1-lupinyl-2-(p-methoxy)benzyl-5-trifluoromethylbenzimidazole].
Explore the source record for details and available documents.
Anilides↗
[Dialkylaminoalkylbenzimidazoles of pharmacological interest. 3].
Explore the source record for details and available documents.
Amines↗
[Preparation of variously substituted beta-benzotriazolylbutyric acids with potential choleretic activity].
Explore the source record for details and available documents.
Butyrates↗
[Preparation of beta-benzimidazolyl- and indazolylbutyric acids as potential choleretic agents].
Explore the source record for details and available documents.
Benzimidazoles↗
[Preparation of cyclopentyl- and cyclopentenyl- alkylamines pharmacological interest].
Explore the source record for details and available documents.
Amines↗
[Synthesis and pharmacodynamic properties of various lupinane derivatives].
Explore the source record for details and available documents.
Acetylcholine↗
[Facotoxic action of alpha, beta-insaturated carbonylic substances and beta-naphtyl derivatives (experimental study)].
Explore the source record for details and available documents.
Animals↗
[Dialkylaminoalkylbenzimidazoles of pharmacological interest].
Explore the source record for details and available documents.
Analgesics↗
[Effect of benzotriazolylalkanoic acids and alkylbenzotriazoles on plant growth].
Explore the source record for details and available documents.
Plant Growth Regulators↗
[Preparation of various isonicotinoyl-hydrazones of cyclones and isonicotincyl-cycloalkyl-hydrazines].
Explore the source record for details and available documents.
Animals↗
[Benzotriazolyl-alkyl-benzimidazoles and their dialkyl-aminoalkyl derivatives].
Explore the source record for details and available documents.
Benzimidazoles↗
Detection and mass spectrometric characterization of the major urinary and fecal metabolites of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]-quinolizine in the rat.
The metabolic fate of 9-methyl 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (MIQ), a compound with promising pharmacological action on the CNS system, was investigated in the rat after an oral dose of 200 mg/kg, the maximal tolerated dose. Urine and feces were collected, exhaustively extracted with organic solvents and the metabolites detected by TLC analysis. The structures of the isolated metabolites were characterized by several mass spectrometry techniques (FD, EI, CI) and, in some cases, confirmed by synthesis. The major metabolic pathways of MIQ in the rat involve: C-oxidation of the methyl group in position 9 to a primary alcohol and to a carboxylic acid, N-oxidation of basic nitrogen and C-oxidation of the quinolizidine nucleus, probably at position 7.
Animals↗