Introduction to toxicity evaluation session.
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Animals↗
Biomedical subjects
F Sperling
Publications and source records attributed to F Sperling.
Pregnancy-associated plasma proteins in pregnant and pseudopregnant rats.
As in the human, the rat pregnancy-associated plasma proteins consisted of four distinct entities as revealed by immunological methods. All showed gradual increases during gestation and rapid disappearance postpartum. They could be physicochemically, although not immunologically, tentatively related to the human pregnancy proteins. None of them was detectable in the serum of rats at various stages of pseudopregnancy, nor in nonpregnant rats.
Animals↗
Biological parameters and the acute LD50 test.
The acute LD50 is an inadequate index of toxicity because the catastrophe of death obscures the mechanisms and sites of action. Thus, nonlethal toxicity is not evaluated, and the LD50 is not extrapolated to the possible effects of low level exposures for long periods of time. Collaborative studies should be undertaken which would develop methods to reasonably permit such evaluation and extrapolation.
Biological Assay↗
A study of the potential teratogenic effects of pentachloronitrobenzene in rats.
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Abnormalities, Drug-Induced↗