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Biomedical subjects

F Spertini

Publications and source records attributed to F Spertini.

95 records · Page 6Linked to original sources
PubMed1983

[Clinical and microbiological aspects of peritonitis in patients treated with continuous ambulatory peritoneal dialysis].

Over a 3-year period 22 episodes of peritonitis were observed among 20 patients treated for end-stage renal failure by CAPD. This represents an overall incidence of 1 episode every 9.5 patient-months (1/14.2 months in 1981, 1/11.3 months in 1982). Eight patients out of 20 never developed peritonitis, and 6 had one episode only. Cocci + were the most frequent culture finding. Two episodes of mycotic peritonitis and 1 sterile peritonitis were observed. Antibiotic treatment was generally successful within 24 h. The incidence of peritonitis was higher among diabetic (1/7 months) than among non-diabetic patients (1/12.6 months). Patient selection, the bag connection technique and the experience accumulated by the dialysis team appear to be the principal factors in lowering the incidence of this complication.

Adult↗
PubMed1983

The carpal tunnel syndrome in chronic dialysis patients, it is a late complication of the arterio-venous fistula?

Out of 100 patients undergoing chronic hemodialysis in Lausanne (Switzerland), 12 developed a carpal tunnel syndrome (i.e. 8 men and 4 women, from 34 to 76 years old). Out of 66 patients with an arteriovenous fistula for less than 4 years, it is interesting to note that only 3 carpal tunnel syndrome were observed; whereas, out of 34 hemodialysis patients being dialyzed more than 4 years, 9 of them showed that syndrome. The symptomatology of the carpal tunnel syndrome is described by the authors. It has always been confirmed by EMG. On 10 patients, the symptoms were so acute that they needed a decompression of the median nerve. Five cases were bilateral. The operation is performed under axillary block, without tourniquet. The results were very satisfactory. Paresthesias disappeared after a few hours or a few days following the operation. No relationship could be established between CTS and the type of nephropathy, severity of polyneuropathy, Ca and P metabolism, vascular access complications, efficacity of dialysis, fluid overload or medical treatment. The authors are investigating the etiology of the carpal tunnel syndrome, ship hypothesize particularly concerning the direct or remote relation between the carpal tunnel syndrome and the arteriovenous fistula.

Adult↗
PubMed1981

The opposing effects of chronic angiotensin-converting enzyme blockade by captopril on the responses to exogenous angiotensin II and vasopressin vs. norepinephrine in rats.

To study the influence of acute and chronic angiotensin-converting enzyme blockade on the pressor response to exogenous angiotensin II, vasopressin and norepinephrine, we gave normal female Wistar rats 100 mg of captopril or 1 ml of 5% glucose twice daily by gavage for 2 weeks. On the 15th day, rats were anesthetized with pentobarbital, and dose-response curves to angiotensin II, lysine-vasopressin, and norepinephrine were obtained before and after intraperitoneal injection of 100 mg/kg of captopril or 1 ml of 5% glucose. Acute as well as chronic converting enzyme blockade enhanced the pressor response to exogenous angiotensin II. Similarly, sensitivity to exogenous vasopressin was increased by both acute and chronic converting enzyme inhibition. In contrast, chronic converting enzyme blockade significantly blunted the response to exogenous norepinephrine, whereas acute blockade tended to accentuate its pressor effect. These results suggest that chronic angiotensin-converting enzyme blockade may partly inhibit sympathetic activity which, in turn, might contribute to the antihypertensive efficacy of this therapeutic approach. These results also point to an important physiological interaction between the two pressor hormones, angiotensin II and vasopressin.

Angiotensin II↗
PubMedDate not supplied

The potential of bronchoalveolar lavage in the prognosis and treatment of connective-vascular diseases.

Interstitial lung disease (ILD) has a poor prognosis in a significant number of patients with connective vascular disease (CVD). By bronchoalveolar lavage fluid (BALF) analysis, ILD may be demonstrated in nearly half of patients with CVD prior to any alteration in lung function or chest radiograph. High neutrophil and eosinophil counts are usually associated with a high risk of functional deterioration, whereas the presence of increased lymphocytes correlates with a better outcome. Furthermore, initiation of therapy (steroids and/or cytotoxic agents) early in the course of disease is predictive of a better response. Cell differentials in bronchoalveolar lavage (BAL), together with measurements of cell by-products and techniques such as high resolution computed tomography, may contribute in the near future to help characterize those patients with the highest risks of evolution to pulmonary fibrosis, and to determine the most favorable time in the course of the disease for the initiation of therapy.

Bronchoalveolar Lavage↗