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F Spizzirri

Publications and source records attributed to F Spizzirri.

7 recordsLinked to original sources
PubMed1998

Steroids in the hemolytic uremic syndrome.

To determine whether steroids could be of clinical benefit in the treatment of the hemolytic uremic syndrome (HUS), we conducted a randomized, double-blinded, placebo-controlled trial of methylprednisone (5 mg/kg per day in four oral doses over 7 days), in children with HUS during the acute phase. Ninety-two patients with typical HUS (47 receiving placebo and 45 receiving steroids) were investigated for neurological, hematological, and nephrological variables. There were no differences between groups in the number of convulsive episodes or transfusion requirements during the hospital stay. Serum creatinine levels were slightly increased on day 10 in the placebo group compared with the steroid group (P = 0.06) and declined significantly between days 1 and 10 only in the steroid group (P = 0.001). In the 51 patients with anuria (24 placebo, 27 steroids), median serum creatinine levels were reduced in the steroid group compared with the placebo group on the 10th day (P = 0.01). Differences in median days of oliguria [11.5 versus 8 (P = 0.28)], anuria [5 versus 7 (P = 0.20)], and dialysis [12 versus 10 (P = 0.26)] for the placebo and the steroid group respectively were not significant. Our data suggest that oral steroids are not able to modify hematological, neurological, or nephrological clinical parameters during the acute phase of childhood HUS, even though they do seem to be associated with a more rapid decline in serum creatinine levels.

Acute Disease↗
PubMed1991

[T and B lymphocytes and NK cells in hemolytic uremic syndrome].

Hemolytic uremic syndrome (HUS) is a serious problem in Argentina, where 50% of the known cases are reported to come from. In the so-called "typical" HUS, anemia, thrombocytopenia and acute renal failure are usually preceded by an episode of infection. Many agents such as bacteria, toxins and viruses have been linked with the prodromal episode, but the reason for the occurrence of HUS in only a small portion of individuals with identical previous symptoms, is not clear. The hypothesis of a particular immune response modifying the susceptibility of some hosts to develop the syndrome after an otherwise well tolerated infection is not formally excluded. The aim of our work was to explore some immunological parameters in order to add more data concerning the immunologic changes occurring during the acute phase of HUS in 24 pediatric patients. We coincide with previous authors on the normal values of serum complement levels and the increase of IgG, IgA and IgM concentrations. (Table 1). We also report a significant and transient decrease in the percentage of T lymphocytes and an increase in the relative number of B lymphocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

B-Lymphocytes↗