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F Stöckmann

Publications and source records attributed to F Stöckmann.

65 records · Page 4Linked to original sources
PubMed1980

Trypsin radioimmunoassay in the diagnosis of chronic pancreatitis.

Serum immunoreactive trypsin (IRT) determination has been recommended as a screening test in chronic pancreatitis. Using a commercial radioimmunoassay kit (RIA--gnost Trypsin; Behring-Werke, Marburg/Lahn, FRG) the interassay coefficient of variation was 26--44% for three different test sera. Gel filtration chromatography profiles revealed immunoreactivity in the position of 125I-trypsin and (less than 50%) in the void volume. The test was evaluated in controls (n = 90), chronic relapsing pancreatitis (CRP;n = 60) and after total pancreatectomy (n = 5). In 65% of the CRP cases decreased IRT values were found, whereas during acute attacks of CRP supranormal and normal values were found. After total pancreatectomy IRT levels were undetectable. It is concluded that the sensitivity of this IRT test is limited and that the available test system needs improvement.

Cholecystokinin↗
PubMed1980

Plasma-immunoreactive trypsin in chronic renal failure.

Plasma-immunoreactive trypsin (IRT) was measured by radioimmunoassay in 52 patients with chronic renal failure. 29 were on conservative treatment, 14 on-regular haemodialysis, and 9 on regular haemofiltration. IRT levels were elevated in those with raised plasma creatinine and there was a significant positive correlation to plasma creatinine concentrations (r = 0.853; p less than 0.001). IRT levels were not significantly altered by haemodialysis or haemofiltration. It is concluded that the kidney plays an important role in the metabolism of plasma trypsin. Since plasma IRT levels may be elevated in patients with chronic renal failure, the IRT determination may be misleading in diagnosing acute and chronic pancreatitis in the presence of kidney disease.

Creatinine↗