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Biomedical subjects

F Sturmans

Publications and source records attributed to F Sturmans.

97 records · Page 6Linked to original sources
PubMed1984

Mammographic breast pattern and the risk of breast cancer.

Within the Nijmegen breast cancer screening programme a study was made of the relation between mammographic breast features according to Wolfe's classification and breast cancer risk. The time of follow-up was 6 years. The Nijmegen study challenged the strong relationship previously suggested. In comparison with women of N1 and P1 breast type, the relative risk for women with P2 and DY breast type was estimated at 0.7, with 95% confidence limits of 0.2 and 2.4, after adjustment for the major risk factors. The results could not be explained by intra-observer variability or left-right difference.

Adult↗
PubMed1977

Estimation of the possible effect of interventive measures in the area of ischemic heart diseases by the attributable risk percentage.

In epidemiology the concepts of relative and attributable risk are used to describe the statistical association between the incidence of a disease and the presence of possible risk factors. If the association is due to a cause-effect relationship, the attributable risk can be considered as an estimate for the reduction in incidence as a consequences of intervention. In order to get unbiased estimates these risks must be standardized for the influence of confounding variables. From data of the Framingham Study these risks, standardized for the confounding influence of age, are estimated for three risk factors related to the incidence of coronary heart disease (CHD)--hypertension, hypercholesterolemia and cigarette-smoking--both marginally and jointly. Under very optimistic assumptions a theoretical reduction in 12-year CHD incidence of a maximum of about 20% is estimated from the male Framingham sample by assumedly lowering systolic blood pressure and serum cholesterol. If only cigarette-smoking could be totally eliminated, the reduction is estimated at about 37%.

Adult↗
PubMedDate not supplied

Predictors of toenail selenium levels in men and women.

Potential predictors of toenail selenium levels were studied in 1211 men and 1248 women aged 55-69 years. These subjects were randomly selected cohort members without prevalent cancer (other than skin) participating in a prospective study on diet and cancer in the Netherlands. Information on the considered potential predictors (gender, age, smoking, intake of dietary selenium and alcohol, Quetelet index) was collected together with toenail specimens in 1986. The average toenail selenium concentration was significantly (P < 0.001) lower in men than in women: 0.547 +/- 0.126 microgram/g (mean +/- SD) and 0.575 +/- 0.109 microgram/g, respectively. The gender difference remained significant after adjustment for the other variables in multiple regression analyses. Age was not associated with toenail selenium levels in men or women. An inverse association was observed with current smoking but not with past smoking. The average toenail selenium values for male current smokers were 0.513 +/- 0.106 microgram/g (mean +/- SD) versus 0.571 +/- 0.133 microgram/g for male never- or ex-smokers (P < 0.001). For women these values were 0.548 +/- 0.101 and 0.581 +/- 0.109 microgram/g, respectively (P < 0.001). Dietary selenium intake was positively associated with toenail selenium levels in multivariate analyses (P < 0.001), but the association was weak (partial r = 0.09). Alcohol intake and Quetelet index were not significant independent predictors of toenail selenium. The observed associations had similar directions in men and women but were stronger in men.

Age Factors↗