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Biomedical subjects

F Sutter

Publications and source records attributed to F Sutter.

At least 19 recordsLinked to original sources
PubMed2004

Digestive and metabolic utilization of lauric, myristic and stearic acid in cows, and associated effects on milk fat quality.

In an experiment with 3 x 6 Brown Swiss cows, the effects of dietary supplementations (40 g/kg) of non-esterified lauric (12 : 0), myristic (14 : 0) and stearic acid (18 : 0) on digestibility, metabolisability, milk fat composition and melting properties were investigated. The diet consisted of forage and concentrate in a ratio of 3 : 2. Cows were fed the C18 : 0 supplemented diet for 10 days before treatment feeding started for a 15-day experimental period where, at the end, excreta were quantitatively collected and gaseous exchange was measured. The DM intake averaged 17.9 kg/d for the C14 : 0 and C18 : 0 diets and was reduced (P < 0.05) by 18% in the C12 : 0 diet. The realised intakes of total C12 : 0, C14 :0 and C18 : 0 amounted to 368, 391 and 617 g/d in the respective groups. The efficiency of ME utilization for lactation was higher (P < 0.001) in the C12 : 0 group than in the two other groups indicating differences in metabolism of C12 : 0 in comparison with C14 : 0 and C18 : 0. Shifts in dietary fatty acid supplementation were clearly reflected in the milk fat composition. Associated changes were elevated CLA and C18 : 1 trans when supplementing C12 : 0, and a high C18 : 1 to C16 : 0 ratio (P < 0.05) in the C12 : 0and C18 : 0 groups which resulted in an easier melting milk fat than with supplementary C14 : 0. Despite certain favourable effects of C12 : 0 in metabolic energy utilization and milk fat melting properties (relative to C14 : 0), more research is needed on how to improve its palatability for dairy cows.

Animal Feed↗
PubMed2002

Methane emissions of differently fed dairy cows and corresponding methane and nitrogen emissions from their manure during storage.

This study investigated the effects of supplementing 40 g lauric acid (C12) kg(-1) dry matter (DM) in feed on methane emissions from early-lactating dairy cows and the associated effects on methane, nitrous oxide and ammonia release from the manure during storage. Stearic acid (C18), a fatty acid without assumed methane-suppressing potential in the digestive tract of ruminants, was added at 40 g kg(-1) DM to a control diet. The complete feed consisted of forage and concentrate in a ratio of 1.5:1 (DM basis). The manure was stored for 14 weeks either as complete slurry or, separately, as urine-rich slurry and farmyard manure representing two common storage systems. Methane release of the cows, as measured in respiratory chambers, was lower with C12 by about 20%, but this was mostly resulting from a reduced feed intake and, partly, from a lower rate of fibre digestion. As milk yield declined less than feed intake, methane emission per kg of milk was significantly lower with C12 (11.4 g) than with C18 (14.0 g). Faeces of C12-fed cows had a higher proportion of undigested fibre and accordingly methane release from their manure was higher compared with the manure obtained from the C18-fed cows. Overall, manure-derived methane accounted for 8.2% and 15.4% of total methane after 7 and 14 weeks of storage, respectively. The evolution of methane widely differed between manure types and dietary treatments, with a retarded onset of release in complete slurry particularly in the C12 treatment. Emissions of nitrous oxide were lower in the manures from the C12 treatment. This partially compensated for the higher methane release from the C12 manure with respect to the greenhouse gas potential. The total greenhouse gas potential (cow and manure together) accounted for 8.7 and 10.5 kg equivalents of CO2 cow(-1) d(-1) with C12 and C18, respectively. At unaffected urine-N proportion ammonia and total nitrogen losses from stored manure were lower with C12 than with C18 corresponding to the differences in feed and nitrogen intake. The present results suggest that manure storage significantly contributes to total methane emission from dairy husbandry, and that the identification of effective dietary mitigation strategies has to consider both the digestive tract of the animals and the corresponding manure.

Ammonia↗
PubMed2002

Effect of calf age and dam breed on intake, energy expenditure, and excretion of nitrogen, phosphorus, and methane of beef cows with calves.

The effects of calf age and dam breeds of different milk yield potential on turnover of energy and nutrients were followed in 16 Simmental and 16 Angus beef cows with Angus-sired calves. Calf ages investigated were 1, 4, 7, and 10 mo. The forage offered for ad libitum access consisted of hay for the calves and of a constant mixture of grass silage, meadow hay, and straw (1:0.7:0.3 on a DM basis) for the cows. Calves of 10 mo of age received an additional 2.6 kg DM/d of crushed barley. The animals were kept in groups of four cows and four calves except in the respiration chambers, where only one cow (tethered) and her calf (loose) were grouped together. Indicator techniques were applied to obtain individual data on feces and urine volumes during group housing. In the Simmental cows, heavier on average by 22 kg, voluntary DMI was higher than in the Angus cows (14.0 vs 12.3 kg/d). In calves, DMI from supplementary feeds was 1.6, 3.9, and 6.3 kg/d, on average, at 4, 7, and 10 mo of age, respectively. Dam breed had no significant effect on DMI and ADG of calves and on BW changes of cows. System retention of energy, N, and P showed a curvilinear development with calf age. System energy expenditure, which linearly increased with calf age, was higher with Simmental than with Angus dams (11%), even when adjusted for metabolic BW (8%). Energy loss through methane linearly increased with NDF intake and, consequently, with calf age from 18 to 30 MJ/d (446 to 751 L/d) for cows and calves together. Similarly, fecal and urinary N excretion and fecal P excretion steadily increased with calf age. In calves, the easily volatile N percentage of manure N rapidly decreased from very high levels in young calves. The resulting changes in inclination to gaseous N loss during manure storage for 8 wk were more than compensated by alterations in N intake of the calves, resulting in an increased total system N loss with progressing lactation. Overall, the present results indicate a difference between Angus and Simmental in efficiency of nutrient and energy utilization that might be explained by the difference in amount of delivery of nutrients to the calves via milk vs forage. Suggestions are made as to how the emissions of N, P, and methane, which were excessive in relation to productivity, could be reduced by nutritional means.

Age Factors↗
PubMed2001

[Acute zonal occult outer retinopathy (AZOOR)].

BACKGROUND: The "white dot syndromes" are a clinically heterogeneous group of inflammatory chorioretinopathies with an inconsistent classification. It is not yet clear if they represent distinct entities or if they are only different forms of the same basic disease. CASE REPORT: A 53-year-old female patient presented with unilateral photopsia and reduced vision in the left eye. Funduscopy of the left eye showed peripapillary confluent whitish infiltrates in the deep retinal layers with corresponding enlargement of the blind spot. Slow progression of the lesions was observed followed by the development of subretinal fibrosis in the macula. The ERG was reduced in the left eye. In both eyes there were small round, partly confluent areas of RPE atrophy in the lower fundus periphery without inflammatory reaction in the vitreous body or anterior chamber. CONCLUSION: The presented case shows overlapping features of acute zonal occult outer retinopathy (AZOOR), multifocal choroiditis and diffuse subretinal fibrosis and uveitis. This case and other previously described cases with overlaps between different clinical entities support the theory that clinically different inflammatory chorioretinal diseases may represent parts of a spectrum of one common disease.

Acute Disease↗
PubMed2001

Effect of water restriction on feeding and metabolism in dairy cows.

We investigated how lactating cows are able to cope with a sustained water restriction. In experiment 1, body weight and meal patterns were recorded with ad libitum access to water (baseline) and during 8 days of 25 and 50% restriction of drinking water relative to ad libitum intake. In experiment 2, indirect calorimetry was combined with nitrogen and energy balance and plasma hormone and metabolite measurements to assess the effects of 50% water restriction on digestion and metabolism. In experiment 1, food intake and body weight declined during the first 3 days of water restriction depending on the restriction level and stabilized thereafter at a lower level. The daily food intake reduction with 50% water restriction was entirely due to a reduction of meal size. The size of the first meal on every day was markedly (>50%) reduced with 25 and 50% water restriction. In experiment 2, urea concentrations in milk and blood as well as plasma sodium and hematocrit were increased by 50% water restriction. Energy balance was not affected by 50% water restriction, but nitrogen balance became negative, because, relative to intake, nitrogen excretion via urine and milk was higher. The lower energy intake during 50% water restriction was compensated by a lower milk production, a higher digestibility of organic matter and energy, and, apparently, a more efficient energy use. Through these changes and a preserved water balance, the cows reached a new equilibrium at a lower water turnover level, which enabled them to cope with a sustained drinking water restriction of 50%.

Animals↗
PubMed2000

Comparative evaluation of rumen-protected fat, coconut oil and various oilseeds supplemented to fattening bulls. 1. Effects on growth, carcass and meat quality.

Growth performance, carcass and meat quality were determined in 36 fattening Brown Swiss bulls fed with maize silage-hay-concentrate based rations supplemented with fats and various oilseeds. The concentrate diet in the control group contained only barley and soybean meal, while the treated groups included, as partial replacement of the concentrate, rumen-protected crystalline fat, coconut oil, whole crushed rapeseed, sunflower seed or linseed, providing additional 3% fat of total ration dry matter. Animals were housed in groups of six with one representative of each treatment in a monofactorial design and feed was offered using transponder controlled equipment. Daily gains were similar for control, protected fat, rapeseed and linseed treatments (1240 g/d on average), but were lower (P < 0.05) with sunflower seed (1135 g/d) and coconut oil (1038 g/d). Corresponding differences (P < 0.05) in carcass weights were observed. All fat supplemented groups had reduced rumen fluid protozoa counts (P < 0.05). Carcasses tended to be leaner with the fat supplements. Mostly no significant effects on other carcass quality (dressing percentage, conformation score) and meat quality traits (final pH, cooking loss, shear forces) as well as composition (dry matter, fat, collagen) occurred. Consequently, rumen protected fat and some oilseeds can be recommended to be fed to growing cattle as energy sources.

Animal Feed↗
PubMed2000

Comparative evaluation of rumen-protected fat, coconut oil and various oilseeds supplemented to fattening bulls. 2. Effects on composition and oxidative stability of adipose tissues.

The effects of five different dietary fat supplements on fatty acid composition and oxidative stability of subcutaneous and kidney fat were evaluated in 36 Brown Swiss bulls and compared to a low fat diet in a monofactorial design. The following fat supplements were provided as additional fat at 30 g per kg feed dry matter: crystalline rumen-protected fat, coconut oil, and three types of crushed whole oilseeds (rapeseed, sunflower seed and linseed). Adipose tissues reflected differences (P < 0.05) in dietary fatty acid composition although to a lower extent. Using protected fat, which contained elevated levels of trans fatty acids, and sunflower seed, containing a high proportion of linoleic acid, significantly increased C18:1 trans fatty acid proportion in the adipose tissues. The use of sunflower seed increased conjugated linoleic acid. The oilseeds resulted in lower amounts of C16:0 in favour of C18:0. Except for linseed, all fat supplemented groups improved oxidative stability of adipose tissues as compared with control. This was explained by lower proportions of unsaturated fatty acids in adipose tissue (protected fat), by elevated alpha-tocopherol contents (rapeseed, sunflower seed) or by a combination of both (coconut oil). Fat colour remained unaffected by treatments. Compared to other fat supplements oilseeds, especially sunflower seed and rapeseed, can therefore be recommended to be fed to bulls in order to increase the proportions of C18 unsaturated fatty acids in adipose tissues and to maintain or improve oxidative stability.

Adipose Tissue↗
PubMed2000

Lactational and metabolic effects in cows of lysine and methionine added to a ration deficient according to the I.N.R.A. method.

The effects of adding lysine and/or methionine to a ration of calculated deficiency in these amino acids of 10% and 20%, respectively, were studied in 24 Brown Swiss cows. The mixed rations (27% grass silage, 19% maize silage, 5% hay and 49% concentrate on DM basis) contained 14.5% CP on average. Lysine supply was selectively elevated by adding fish meal in exchange for other concentrate ingredients. Methionine was supplied in a rumen-protected form. Milk protein content was elevated whereas fat amount decreased by adding both amino acids. Lactose content increased without additional lysine from fish meal. Live weight, milk yield, milk fat content and protein amount remained unaffected by any variation of amino acids supply. Also nutrient digestibility and nitrogen balance were not changed by the treatments. Blood plasma concentrations confirmed the assumed variation in metabolic lysine and, less clear, methionine supply. Effects on plasma concentrations of other amino acids were relatively small. Most plasma hormones and enzymes, and metabolites in plasma, urine and milk did not respond to the variation in amino acid supply. Lysine addition via fish meal increased aspartate amino transferase and decreased urinary allantoin concentration. Additional methionine elevated plasma ornithine. Overall lysine and methionine appear to have been only marginally deficient in the unsupplemented ration fed for 3 weeks despite the deficiency of 10% to 20% as calculated by the I.N.R.A. method.

Amino Acids↗
PubMed2000

Quantitative effects of feed protein reduction and methionine on nitrogen use by cows and nitrogen emission from slurry.

The effects on N use and N volatilization from slurry were investigated in 24 early-lactation Brown Swiss cows (32 kg/d milk) fed four diets with 128, 124, 147 and 175 g/kg DM of crude protein (CP). All diets were supplemented with 0.75 g/kg of rumen-protected Met except for one of the low-protein rations (128 g/kg of CP). The unsupplemented low-protein ration was calculated to be deficient in Met by approximately 20%. No significant treatment effects on performance, water intake and excretion, and slurry quantities were observed. Differences in N intake were closely reflected in the daily excretions of total and urea N via urine, and in urine N as a proportion of total excretory N. These values were higher for the unsupplemented low-protein ration than for the Met-supplemented low-protein ration. The treatment effects on fecal N excretion were generally smaller, and milk N excretion and N balance were not affected. Feed N utilization for milk N excretion increased with decreasing CP content from 27% for the high-protein group to about 35% for the two low-protein groups. Comparing the Met supplemented rations only, ammonia N emission from fresh slurry (excreta:water = 1:0.5) decreased from 231 to 160 and 55 microg/s per square meter of surface with 175, 147 and 124 g/kg of CP, respectively, and the corresponding total N losses during 7 wk of slurry storage declined from 89 to 57 and 25 g/d per cow. Regression analysis demonstrated the basic suitability of milk urea N excretion to estimate urine N excretion and, consequently, potential N emissions.

Animals↗
PubMed1999

[Migration of Kirschner wires after surgical stabilization of injuries in the area of the shoulder--4 case reports].

Internal fixation is recommended for displaced and unstable fractures of the lateral clavicle and fractures involving the proximal humerus. Kirschner wires, although recommended in the orthopedic literature bear the risk of wire breakage and migration. 4 cases with serious and potentially hazardous complications are presented. All reported complications occurred years after the operative treatment without clinical symptoms. Regular postoperative follow-ups and early hardware removal after fracture healing is recommended.

Adult↗
PubMed1999

Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers.

Prolonged infusions of bacterial lipopolysaccharides (LPS) are known to model gram-negative bacterial infections, but the basic mechanisms of the LPS effects on feed intake and metabolism and their potential interdependence are largely unknown. The aim of the present study was to distinguish and to better characterize the feeding suppressive and metabolic effects of LPS. Six heifers were infused intravenously for 100 min with either 1) LPS (2 microg/kg BW) with free access to feed, 2) saline with free access to feed, or 3) saline with feeding restricted to the amount of feed consumed after LPS infusion. Feed intake, body temperature, plasma concentrations of various metabolites and hormones, and the respiratory quotient and heat production were measured. The LPS reduced feed intake and induced pronounced changes in metabolic energy turnover and fat and carbohydrate metabolism that were largely independent of the concomitant feed intake reduction. Some of the metabolic changes were biphasic; the first phase resembled a stress response with increases in plasma glucose and cortisol, and the second phase reflected a beginning energy deficit with low plasma glucose and enhanced lipolysis. The coincidence of a short-term surge of plasma insulin with marked transient decreases in plasma FFA, glycerol, and beta-hydroxybutyrate as well as with the transition from hyper- to hypoglycemia indicates that insulin plays a role in some of the metabolic responses to LPS. The failure of LPS to clearly increase energy expenditure despite the increase in body temperature suggests that anaerobic mechanisms of heat production and, perhaps, a reduced peripheral blood flow contributed to the fever. Many of the initial metabolic responses occurred before and, therefore, independent of, an increase in circulating tumor necrosis factor-alpha.

Adipose Tissue↗
PubMed1998

Osseointegration of dental implants in bone irradiated with 40, 50 or 60 gy doses. An experimental study with beagle dogs.

Construction of different kinds of prostheses on irradiated bone tissues after tumour surgery is a complicated part of modern implantology. In irradiated regions of the jaws where the bone layers are thin and the blood supply also is minimal, knowledge of the impact of each dose of radiation is very important. The aim of this study was to compare the bone response around titanium implants loaded with fixed bridges in dog mandibles irradiated with total doses of 40, 50 or 60 Gy. The results suggest that after irradiation with 40-50 Gy, when the dose is fractioned in order to achieve higher tolerance of the tissues compared with single dose irradiation, titanium implants may become osseointegrated in the mandibles. For high success rates, however, careful planning of radiotherapy and selection of implantation site with an adequate blood supply are essential.

Animals↗
PubMed1997

Titanium implants and lateral forces. An experimental study with sheep.

The purpose of this study was to investigate the resistance of titanium implants to horizontal forces in a sheep model. Twenty implants were inserted into the foreheads of 5 sheep, 4 implants on each animal. After a healing period of 3 months, abutments were mounted on the implants. After a further healing period of 3 weeks, the implants were loaded with a horizontal pull of orthodontic elastics. The force varied between 250 and 350 grams. The duration of loading was 3 months. After the loading period the animals were sacrificed and the forehead bones with implants were fixed in formalin and evaluated histologically. In the histological specimens no signs of infection or bone loss were found around the implants. The results of the present study encourage the use of titanium implants also in cases where constant lateral forces are present.

Animals↗
PubMed1997

Implant dentistry--development and current focus.

Today, implant dentistry plays an important role in the maintenance of chewing function and oral health. For thirty years now oral implants and methods for implantation have been developed further to assure a lifetime stability of these devices and to optimize function and esthetics. Starting with the treatment of fully edentulous patients, oral implants are now used for the reconstruction of partially edentulous patients as well. Thereby, implants not only replace missing teeth but also help to preserve intact remaining teeth. They are usually incorporated to improve the patient's subjective chewing comfort. The present paper gives an overview of the development and the current state of the art of oral implants, as well as their clinical indications.

Animals↗
PubMed1996

Characterisation of the acute phase response of heifers to a prolonged low dose infusion of lipopolysaccharide.

The effect of a prolonged low dose infusion of bacterial lipopolysaccharide (LPS) on acute phase-like reactions was examined in heifers. LPS (2 micrograms kg-1 dissolved in 100 ml water), or saline was infused (at 1 ml min-1) intravenously for 100 minutes and blood samples were taken at various times before, during and after the infusion. The serum concentrations of tumour necrosis factor-alpha (TNF alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and serum amyloid A (SAA) and the rectal temperature increased in response to the LPS infusion. Serum TNF alpha increased before the increases in IL-1 beta and IL-6 and remained high from 20 minutes after the onset of the infusion until the end of the sampling period (six hours). The LPS-induced increases in serum IL-1 beta and IL-6 were biphasic. Plasma cortisol and lactate concentrations also increased, and plasma glucose and beta-hydroxybutyrate concentrations decreased in response to the LPS infusion. The similarity of these reactions to changes observed in response to bacterial infections shows that the prolonged infusion of low doses of LPS is a good model for studying the acute phase response to Gram-negative bacterial infection in heifers.

Acute-Phase Proteins↗
PubMed1996

Transversal fixation of restorations in combination with the Octa abutment of the ITI Dental Implant System.

In aesthetically demanding locations of the dentition, the replacement of a single tooth by means of an oral implant is often difficult because of technical limitations of the abutments systems used. The transversal Fixation System in combination with the Octa abutment of the ITI Dental Implant System presents a novel development to overcome these limitations. The report describes the engineering and design of this technical development.

Dental Abutments↗
PubMed1994

Immediate transmucosal implants using the principle of guided tissue regeneration. I. Rationale, clinical procedures and 30-month results.

The installation of implants directly into extraction sockets offers considerable advantages over other treatment modalities for both practitioners and patients. Usually, immediate implants are placed and subsequently covered by mucosa allowing a submerged healing mode. This report presents the rationale, clinical procedures and results for immediate transmucosal implants. Following an intracrevicular incision and flap elevation, the tooth to be extracted is carefully luxated by means of small elevators to preserve the entire bony housing of the tooth. A titanium plasma-sprayed implant (ITI Bonefit) is then installed at the bottom or in the wall of the extraction socket. An expanded polytetrafluoroethylene barrier membrane (Gore-Tex GTAM) is tightly adapted around the implant post and over the bony margins of the alveolus. The flaps are then replaced, adapted around the neck of the implant and sutured. During nonsubmerged, transmucosal healing of the site, meticulous plaque control is performed by mechanical and chemical means. Membranes are removed after 5-7 months. Since infection was prevented, the implants obtained stability, healthy peri-implant mucosal tissues were observed and missing bone in the alveoli regenerated. Of 21 transmucosal implants placed into fresh extraction sockets, 20 yielded complete bone fill and coverage of the entire plasma-coated implants surface at the time of membrane removal. This documentation suggests that the immediate nonsubmerged installation of an implant into an extraction socket is a predictable treatment modality with good long-term prognosis.

Adult↗