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Biomedical subjects

F Szarvas

Publications and source records attributed to F Szarvas.

At least 19 recordsLinked to original sources
PubMed1997

Recurrent phyllodes tumor in a man.

The case of a 35-year-old man with a borderline-type cystosarcoma phyllodes is presented. Four years after the primary excision of the tumor, wide excision of a local recurrence and postoperative radiotherapy were performed. No repeated relapse was observed during a 5-year follow-up. Neither significant endocrine changes nor genetic alteration could be proven. However, a slightly increased SHBG concentration was detected, resulting in a decreased biologically available androgen level reduced testosterone/SHBG index. This phenomenon might be a consequence of the chronic liver disease of the patient due to his type II diabetes mellitus and alcohol abuse. In addition to the conventional histopathological examinations, immunohistochemical and electron-microscopic investigations were carried out on tissue sections, and the steroid receptors, EGF receptors and EGF-like activity of the tumor were also studied.

Adult↗
PubMed1992

Two families with hereditary diabetes insipidus not due to osmoreceptor failure.

Two families with hereditary central diabetes insipidus (CDI) are reported. The pedigree in both families shows an autosomal dominant trait. The plasma arginine-8-vasopressin (AVP) determined by radioimmunoassay was markedly lower in these CDI patients than in healthy controls; the difference being even more pronounced after a hyperosmotic challenge. Since in the present study histamine also failed to increase the plasma AVP concentration, the authors consider it unlikely that an osmoreceptor failure would be implicated in the pathogenesis of CDI in these cases. The AVP concentration of the lumbar cerebrospinal fluid was also measured in two members of one of the families: the level found at the lower normal range indicates that some AVP secretion has been maintained in the extrahypothalamic vasopressinergic system of these patients.

Adolescent↗
PubMed1992

[The male climacteric from the practical viewpoint].

A transient physiologic period similar to that in women leads from full sexuality to senium in the life of men, too. This phase may involve the complex of male climacteric symptoms. The diminished testosterone secretion of the testes as endocrine "primum movens", together with an increased level of the carrier protein (SHBG), results in a reduced androgen supply of the organism, as reflected in a low free andorgenic index. The diagnosis of male climacteric is made on the basis of an enhanced serum LH level. With regard to the differential diagnosis, atherosclerosis, diabetes mellitus, chronic alcoholic liver damage, malignant tumors and prostatic complaints are particularly to be considered. The hormonal treatment consists of low-dose testosterone medication; for the prevention of osteoporosis, however, testosterone preparations may be replaced by anabolic steroids. As for women, the concomitant vegetative phenomena of the climacteric syndrome should be alleviated symptomatically.

Climacteric↗
PubMed1991

Central effects of antiserum against human atrial natriuretic polypeptide on water and electrolyte metabolism and plasma arginine-8-vasopressin level in conscious rats.

Although synthetic atrial natriuretic polypeptide (ANP) is known to influence the water and electrolyte metabolism and arginine-8-vasopressin (AVP) secretion, the physiological role of endogenous ANP in the rat brain is still unclear. Accordingly, an investigation was made of the effects of intracerebroventricular (icv) administration of human h-ANP antiserum, which can neutralize endogenous ANP, on the water intake, urine output, urinary excretion of potassium and sodium, and plasma AVP level in normally hydrated rats. Apart from the water intake, all the parameters were also determined in 48-h water-deprived rats after h-ANP antiserum treatment. The icv administration of the h-ANP antiserum significantly increased the spontaneous water intake, urine output and urinary potassium excretion in rats given water ad libitum. These effects developed by 24 h after icv treatment. The h-ANP antiserum had no effect on the urine volume in 48-h water-deprived rats, suggesting a primary effect of endogenous ANP in the brain on the spontaneous water intake in rats given water ad libitum. These results suggest that ANP may have a physiologically important role in the central regulation of the water and electrolyte metabolism. The h-ANP antiserum did not alter the basal and dehydration-induced AVP release. This raises the possibility that the endogenous ANP in the brain may not participate in the control of AVP secretion.

Animals↗
PubMed1991

Hyperlipemia and hyperlipoproteinemia [HLP] screening among the children from premature myocardial infarction risk families.

Serum lipids and lipoproteins were investigated in the premature myocardial infarction (PMI) risk families before 45 years of age with the aid of screening for hyperlipemia and hyperlipoproteinemia (HLP): in the case of 174 persons from Csongrád County from the Departments of Internal Medicine I and II and of 42 patients (fathers) suffering from PMI and their 79 "high risk" children from Heves County. In the investigated three groups of "high risk" children the genetically determined antiatherogenic HDL-Ch level diminished in 34.8, 52.3, 40.5 per cent. Significant negative correlation was detected between the serum HDL-Ch and beta-lipoprotein; significant positive correlations were found between the HDL-Ch and the serum lipase activity; between the beta-lipoprotein and the phospholipid level; significant negative correlation was proved between the HDL-Ch and the phospholipid level in the group of PMI patients and their offsprings. The Ch/Tg, and the HDL-Ch ratios were significantly diminished in the PMI patients' group against the risk children' group, while the Ch/HDL-Ch rate was significantly elevated.

Adolescent↗
PubMed1990

Andrology today.

Andrology is an interdisciplinary field of medicine which developed in the second half of this century. Schirren was the first one to use this term. In Hungary, andrology was established by Jenö Molnár. Certain question of topical interest of andrology are discussed in the present study. Besides the endocrinologically well definable male hypogonadism caused by primary lesions of the hypothalamus-pituitary-testis-androgen periphery system andrological anomalies of known or unknown origin also occur in a great number of cases. As collective designation the use of "consecutive hypogonadisms" is recommended for these conditions. Other endocrine and non-endocrine disturbances, injuries of the male gonad system caused by drug therapy, environmental noxa and unknown factors may be ranged also into this group. In vitro fertilization applied in certain cases of infertility and cryostorage of human embryo pose several problems even to the andrologist. The development of an effective and harmless male contraceptive has to be realized in the future. The diagnosis of male climacteric may be assessed only after excluding other diseases. For the treatment of this condition low doses of androgen preparations are recommended.

Contraceptives, Oral↗
PubMed1989

[Increased androgen-binding capacity and decreased free androgen index in male alcoholics with liver disease].

Androgen binding capacity in the serum of 30 male patients under 51 years of age suffering from chronic alcoholic liver disease was investigated with tritiated 5 alpha-dihydrotestosterone. The result received by saturation analysis is regarded as an indicator of the SHBG (sex hormone binding globulin) content of the blood. Testosterone was measured simultaneously and the free androgen index (FAI) was calculated. The diagnosis of liver disease was based on case histories, physical symptoms and laboratory abnormalities, in some cases on liver biopsy too. Age-matched control group consisted of 18 healthy males. The results showed markedly elevated androgen binding capacities (SHBG contents), testosterone values in the normal range and significantly decreased FAI, indicating insufficient amounts of biologically active testosterone.

Androgen-Binding Protein↗
PubMed1988

[Recommendation for the classification of male hypogonadism].

For the adequate therapy and prognosis the division of the forms of male hypogonadism is of practical significance. The clinical picture is determined by 4 factors (dimensions): 1. On the basis of the vertical dimension hypogonadism can be hypothalamic, hypophyseal, testicular or peripheral in its origin; 2. Depending on the impaired testicular functions (single or both), hypogonadism can be selective or total; 3. Depending on the severity of the lesion hypogonadism can be complete or incomplete; 4. the time-factor indicates the beginning of the lesion (pre- or postpuberal). The duration of the lesion is also of clinical significance. For the division of male hypogonadism, two etiopathogenetical groups can be suggested: Group I: "Classical" male hypogonadism. Hypothalamus-hypophysis-testis system primarily damaged; Group II: "Consecutive" male hypogonadism. Hypogonadism induced by other diseases.

Humans↗
PubMed1987

[Andrological abnormalities in internal diseases and following drug therapy].

In the present paper the following non-endocrine internal diseases are discussed: liver cirrhosis, diabetes, chronic renal failure and morbus Crohn. In alcoholic liver patients under fifty, hypospermia and oligozoospermia can be observed. The hormone assays showed moderately increased FSH- and LH-values in the serum; prolactin, testosterone and estradiol remained normal. An increased binding of testosterone to SHBG is supposed, and the androgen deficiency symptoms are considered to be due to the elevated binding of testosterone to SHBG. The other non-endocrine internal diseases and drug-groups (cytostatics, steroids, neuroleptics, antihypertensives, antiarrhythmics, nitrofurans, levamisole, fungicides and salazosulfapyridine) are reviewed on the basis of literature. After the administration of 1 g per day of cimetidine for four weeks in patients under fifty with duodenal ulcer, notable andrological side effects were not revealed by neither clinical nor hormone examinations.

Cimetidine↗
PubMed1983

[Andrologic anomalies in various gastrointestinal diseases].

In several gastroenterological diseases andrological anomalies have become known. From this point of view up to now the liver cirrhosis has been examined most frequently. In patients with cirrhosis apparently the two functions of the testicles are disturbed. On the one hand, a decreased or missing fertility is to be assumed, on the other hand, a cirrhosis does not always exclude the procreative capacity. The hormone analyses plead for the fact that the hypogonadism might rather be conditioned testicularly, in which case the direct toxicity of alcohol may be of importance. In haemochromatosis the hypogonadism develops by a combined mechanism. The cystic fibrosis of the pancreas is practically always associated with a male infertility. In Crohn's disease a disturbance of the spermatogenesis is observed. Even the salazo-sulphapyridine therapy is accompanied by unfavourable influences on the spermiogramme. Cimetidine used in the ulcer therapy shows a certain antiandrogenic effect and after a longer time may evoke impotence and other undesirable andrological side-effects which we, however, did not realize in 4 weeks treatment periods.

Cimetidine↗
PubMed1976

Effect of alpha-pinene on the mixed function microsomal oxidase system in the rat.

The microsomal fraction of the liver was studied for protein and cytochrome P 450 contents as well as for aminopyrine N-demethylase and aniline hydroxylase activity and for its butylisocyanide spectrum under the effect of alpha-pinene treatment. A moderate increase was found in the amount of microsomal protein and cytochrome P 450, a marked increase in the metabolism of both aminopyrine (substrate of type I) and aniline (substrate of type II), together with an increase in the butylisocyanide-absorption maxima of both haemoproteins involved in the reaction. Thus, alpha-pinene is a broad-spectrum enzyme inductor of the phenobarbital type, with certain quantitative differences.

Aminopyrine N-Demethylase↗
PubMed1975

[Hypogonadism in male patients with chronic liver disease].

On the basis of own investigations of the testosteron metabolism in hepatopathy must be assumed that the hypogonadism appearing in liver diseases is to be regarded as peripheral form, i.e. it is not centrally evoked by gonadotropin insufficiency. An own pathogenetic concept is discussed.

17-Ketosteroids↗