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Biomedical subjects

F T Fraunfelder

Publications and source records attributed to F T Fraunfelder.

At least 19 recordsLinked to original sources
PubMed1979

Repair of an inadvertent buttonhole or leaking filtering bleb.

Buttonholing of conjunctival flaps at the time of filtering glaucoma surgery or a leak in the flap postoperatively can cause serious problems and may be most difficult to repair. A new delicate atraumatic needle has been used successfully in five cases to close conjunctiva to conjunctiva or conjunctiva to cornea defects.

Aged↗
PubMed1979

Retinal detachments and topical ocular miotics.

There is increasing suspicion that topical ocular miotic therapy in selected persons may precipitate retinal detachments. This is a rare event and probably does not occur in patients free of retinal pathology. Data supporting a possible cause and effect relationship, obtained from the National Registry of Drug-Induced Ocular Side Effects, a survey of the Retina Society, medicolegal decisions, and a review of the literature, is presented.

Administration, Topical↗
PubMed1979

Interim report: National Registry of Possible Drug-Induced Ocular Side Effects.

Recent data concerning 1%, 2.4%, and 10% topical ocular phenylephrine, topical ocular local anesthetics, carbonic anhydrase inhibitors, diazepam, liquid high-protein diets, sodium fluoride gel, naproxen, and thiabendazole are reviewed. Clinicians are encouraged to report possible adverse drug reactions to the National Registry of Drug-Induced Ocular Side Effects, which has been moved to the Department of Ophthalmology, University of Oregon Health Sciences Center, Portland, OR 97201.

Aged↗
PubMed1979

Principles of cryosurgery.

The mechanism by which a cryogen destroys cells is complex. The formation of a hemispherical iceball composed of thermogradients, each of which maintains a temperature proportional to its distance from the application point, initiates the cryoinjury. The cardinal rule of cryosurgery includes a rapid freeze, which produces highly damaging intracellular ice formation and closely-packed thermogradients, coupled with a slow thaw. Multiple freeze/thaw cycles are most destructive, producing ischemic necrosis. Histological and clinical aspects are discussed, as well as complications and follow-up procedures.

Cryosurgery↗
PubMed1979

The use of liquid nitrogen cryospray for treatment of trichiasis.

Cryosurgical destruction of eyelashes has been successful using a double freez-thaw liquid nitrogen spray technique. While other cryogens are successful in treating trichiasis, they are contraindicated in the treatment of malignant eyelid lesions. If the clinician intends to treat both these entities, it would be simpler to use a liquid nitrogen unit; otherwise, two separate cryosurgical instruments would be required. The liquid nitrogen treatment requires two cycles of a rapid freeze to -15 degrees C coupled with a slow thaw and has given us a 90%+ success rate. Contraindications in treating trichiasis with cryotherapy include paralytic lids and heavily pigmented patients. In general, we do not treat trichiasis involving less than one-third of the lid, especially with young, healthy-appearing lid margins.

Cryosurgery↗
PubMed1979

Possible complications secondary to cryotherapy.

Various complications are possible with cryosurgery that the cryosurgeon should be aware of. These include technical problems with the use of liquid nitrogen, skin temperature monitoring, improper patient selection, immediate secondary complications including hyperemia, erythema, bullae formation and edema, and long-term complications including depigmentation, pseudoepitheliomatous hyperplasia, loss of lashes and meibomian glands, lid deformities, scar formation, and destruction of the lacrimal system. Ocular damage has occurred following treatment of conjunctival and corneal lesions, however, not in the treatment of eyelid lesions.

Aged↗
PubMed1979

Decreased libido--a side effect of carbonic anhydrase inhibitor.

Thirty-nine cases of decreased libido in glaucoma patients on carbonic anhydrase inhibitors are reported. This symptom completely reversed or markedly improved after discontinuation of the drug in all cases. Twelve of these patients restarted their carbonic anhydrase inhibitor medication which resulted in a recurrence of decreased libido symptoms. There were 3 cases of impotency which reversed after discontinuation of the drug. Most likely, these symptoms are a result of the malaise and depression occurring in some patients on carbonic anhydrase inhibitor therapy.

Adult↗
PubMed1978

"No-touch" cryosurgical enucleation: a minimal trauma technique for eyes harboring intraocular malignancy.

Current surgical approaches for cancer are emphasizing minimal trauma--the so-called no-touch technique of tumor removal. Tumor seeding through the circulatory system seems reasonable, particularly with friable and necrotic tumors. Attempts to reduce metastatic seeds should originate with the original procedure. Enucleation of nontumor eyes with simultaneous intraocular manometry has shown which surgical maneuvers elevate intraocular pressure and how ocular massage can be avoided. Our surgical procedure involves a delicate surgical technique coupled with transscleral cryocoagulation to immobilize the tumor's blood supply.

Cryosurgery↗
PubMed1977

No-touch technique for intraocular malignant melanomas.

Large variations in intraocular pressure occur during enucleation, scleral depression, 32P testing, and vigorous rubbing of an eye. Data from animal studies show that during a critical phase of an intraocular malignant melanoma, ocular massage significantly decreased longevity due to increased metastastic disease. We report "no-touch" technique to prevent tumor spread from occurring secondary to ocular manipulation during enucleation. This technique avoids IOP elevations above 50 mm Hg before freezing completely around the tumor, thereby preventing flow of fluid and blood to or from the tumor prior to the manipulation necessary for enucleation. Theoretically, the patient with an ocular tumor should be warned against vigorous rubbing of his eyes and hard lid squeezes or diagnostic techniques that elevate IOP. The ophthalmologist should perform enucleation with gentieness and avoid pressure on the globe. Patients who are being followed up with a suspected ocular tumor should be warned not to rub or vigorously squeeze their eyelids.

Animals↗
PubMed1977

Corneal mucus plaques.

Corneal mucus plaques adhered to the anterior corneal surface in 17 of 67 advanced cases of keratoconjunctivitis sicca. The plaques were translucent to opaque and varied in size and shape, from multiple isolated islands to bizarre patterns involving more than half the corneal surface. Ultrastructurally, they consisted of mucus mixed with desquamated degenerating epithelial cells and proteinaceous and lipoidal material. The condition may be symptomatic but can be controlled and prevented in most cases by topical ocular application of 10% acetylcysteine.

Acetylcysteine↗