Biomedical subjects

F T Lester

Publications and source records attributed to F T Lester.

At least 19 recordsLinked to original sources

PubMed1992

Clinical features, complications and mortality in type 1 (insulin-dependent) diabetic patients in Addis Ababa, Ethiopia, 1976-1990.

Clinical features, complications and prognosis of 431 consecutively registered Ethiopian Type 1 (insulin-dependent) diabetic patients seen in the Diabetic Clinic in Yekatit 12 Hospital in Addis Ababa, Ethiopia, from 1976-1990 are reported. Male:female ratio was 1.4:1; mean age at diagnosis was 18.1 years (confidence interval (CI) 1.6) in women and 21.4 (CI 1.2) in men. A history of ketoacidosis at some time was present in 38 per cent, in 11 per cent at diagnosis of diabetes. Tuberculosis was the most common complicating illness, occurring at some time in 16.5 per cent of patients. In addition, 9.5 per cent (CI 4 per cent) were known to have diabetic retinopathy, 6.0 per cent (CI 2 per cent) nephropathy and 7.9 per cent (CI 2 per cent) neuropathy at their last clinic visit. During the 15 years of the study, 9.7 per cent of the patients have died, with a mean duration of diabetes at death of 9.2 years (CI 1.8), and an overall mortality rate of 15.5/1000 person-years of diabetes. Five-year survival was 96 per cent (CI 3 per cent), 15-year survival 82 per cent (CI 9 per cent), and 20-year survival 63 per cent (CI 17 per cent), calculated using the Cox proportional hazards model; prognosis was better in those diagnosed at a younger age (p = 0.029) and in those with a body mass index of > 19 kg/m2 on treatment (p = 0.096).

Adolescent↗

PubMed1991

Clinical status of Ethiopian diabetic patients after 20 years of diabetes.

By January 1990, over a period of 14 years, the Diabetic Clinic at Yekatit 12 Hospital, Addis Ababa had registered 1699 diabetic patients, of whom 204 were first diagnosed in or before 1969. Of these, 68 are known to have died after 11 to 36 years of diabetes (29% in renal failure), and 69 have been lost to follow-up for 3 or more years. Of the 121 who had been diabetic at least 20 years when last seen, 67 are attending, 18 are lost to follow-up, and 36 have died. Of these 121, 36.4% were known to have neuropathy, 29.8% nephropathy, and 45.5% retinopathy. Only 7 (5.8%) were Type 1 patients compared with 18.8% of the whole diabetic clinic, and most were obese Type 2 diabetic patients from Addis Ababa itself. Most of the 67 still attending after 20 to 34 years of diabetes are independent and fully employed, suggesting that the prognosis of diabetes may not be as dismal as has been generally reported from African countries. However, the survivors were mainly economically better-off Type 2 diabetic patients from the capital.

Age Factors↗

PubMed1979

Juvenile diabetes mellitus in Ethiopians.

The clinical features seen in 27 Ethiopian juvenile diabetics, which were similar to those of juvenile diabetics elsewhere, are summarized in this first published report from an African country of childhood diabetes. Control was difficult and admission to hospital frequent because of poverty, uncontrolled diets and irregular supplies of insulin. This group of childhood diabetics represents 9.8% of patients attending a diabetic clinic in Addis Ababa. Survey of the published information on diabetes mellitus in African populations reveals that most series do contain several children and a significant number of teenagers. It is concluded that juvenile diabetes mellitus is not rare in African countries.

Adolescent↗

PubMed1978

Cryptococcal meningitis complicating remote skull fracture.

A patient in whom cryptococcal meningitis complicated a nine year old depressed frontal skull fracture, an association which has not been reported previously, is recorded. This is also the first case of cryptococcal meningitis recognised in Ethiopia.

Adult↗

PubMed1978