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F T Rapaport

Publications and source records attributed to F T Rapaport.

At least 19 recordsLinked to original sources
PubMed1995

Effects of aging upon the expression of differentiation and class II MHC antigens on the surface of T lymphocytes from normal human subjects.

This study documents differences in the expression of differentiation antigens and Class II MHC encoded antigens on the T and B cells of young, adult, and older healthy humans as measured by their density on the cell surface. Marker densities were calculated by fluorescence intensity vector analysis, using two-color flow cytometry. Relative changes in marker densities with increasing age were calculated by expressing younger group marker density values as 100%. The following statistically significant changes were observed with advancing age: (1) Increased density of HLA-DR markers on CD3+ and CD8+ cells and CD4 markers in the "adult" group (ages > 34 < or = 59 years) (1.5-fold, 0.5-fold, and 0.4-fold increases, respectively) when compared with the "young" group (ages < or = 34 years); (2) decreased density of HLA-DR markers on CD3+ and CD8+ cells and CD8 markers in the "older" group (ages > or = 60 years) (0.2-fold, 0.5-fold, and 0.4-fold decreases, respectively) when compared with the adult group. However, when the "older" group was compared to the young group, the density of HLA-DR markers on CD3 cells and the density of CD4 markers and CD8CD57 markers were significantly higher (1-fold, 0.4-fold, and 0.8-fold) and the CD8 markers were lower (0.4-fold). The size score of individual T cell subsets, as measured by forward light scatter, was uniformly smaller in the older age group when compared with the young group (29.5 +/- 4.0% SD); it was also smaller than in the adult group (16.5 +/- 2.7% SD). These observations may be of relevance to the decreased level of host immunologic responsiveness observed with increasing age.

Adolescent↗
PubMed1994

Current status of immunological monitoring in the renal allograft recipient.

With the appropriate combined use of different immune monitoring techniques, it is possible to derive sensitive diagnostic parameters for the transplant surgeon. However, the core biopsy or cytological examination of the graft continues to represent the gold standard for evaluating the specificity and sensitivity of these methods. With the development of newer monoclonal antibodies and a better understanding of the impact of immune processes on the behavior of various activation linked, T cell associated surface antigens, one may be able to secure further valuable information, with enhanced diagnostic and prognostic accuracy.

ABO Blood-Group System↗