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Biomedical subjects

F Tabaraud

Publications and source records attributed to F Tabaraud.

At least 55 records · Page 3Linked to original sources
PubMed1989

Glutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron disease.

We report the results of glutamate dehydrogenase (GDH) and aspartate aminotransferase (AAT) activities in leukocytes of 24 patients with motor neuron disease (MND) and 20 matched control subjects. In 62.5% of patients suffering from MND, we detected a leukocyte GDH deficiency (+/- 2 SD) as compared with the mean value obtained in controls. By contrast, there was no difference in leukocyte AAT activities in affected and nonaffected subjects. Abnormal cellular glutamate metabolism might be involved in the pathogenesis of MND.

Adult↗
PubMed1989

[Epidemiology of amyotrophic lateral sclerosis in the Limousin area].

Several epidemiologic studies of amyotrophic lateral sclerosis have shown a uniform repartition over the world. We report the results of a retrospective study and the preliminary results of a prospective study carried out in the Limousin area. The mean incidence per/year is 0.97/100,000 in the retrospective study and 1.3/100,000 in the prospective study. Such data are similar to those previously reported. The two major findings are the high frequency of bulbar palsy and the high mean age of the patients. This can be associated with the high mean age of the population in the Limousin area as compared to other regions.

Age Factors↗
PubMed1989

[Study of central motor pathways using cortical magnetic stimulation and spinal electrical stimulation: results in 20 normal subjects].

Evoked motor potentials can be elicited by magnetic cortical or electric spinal stimulations. The central conduction time (CCT) corresponds to the difference in latencies between the total conduction time (from cortex to muscle) and the peripheral conduction time (from spinal cord to muscle). CCT is the sum of the conduction time in the cortico-spinal fibers, of the spinal synaptic delay, and of the conduction time in the proximal part of the motor roots. CCT values (mean + standard deviation) were determined in 20 healthy subjects ranging from 21 to 56 years of age (mean 31.2). Results of magnetic cortical stimulation were compared to the results of electrical stimulation of the cortex. CCTs after magnetic cortical stimulation were longer than CCTs after electric cortical stimulation. This could be explained by the fact that electrical stimulation elicits a direct response in the cortico-spinal tract whereas magnetic cortical stimulation has indirect effects on the pyramidal cells of the motor cortex through excitatory interneurons. Compared with electrical stimulation, the magnetic stimulation has the great advantage of being painless and allows a safe evaluation of the central motor pathways in man.

Adult↗
PubMed1988

[Motor evoked potentials. Technic and results in the normal subject].

The transcranial stimulation of the motor cortex and spinal cord was introduced in clinical neurology by Merton and Morton (1980). This reproducible and non invasive technique gives the possibility to elicit unilaterally or bilaterally evoked motor potentials. It is possible to define a Total Conduction Time (TCT) from cortex to muscle and a Peripheral Conduction Time (PCT) from spinal cord to muscle. The central conduction time is given by the latency difference between TCT and PCT. This delay represents the duration of the descending corticospinal volley plus the delay necessary to depolarize spinal motor neurons. For central pathways supplying the upper limbs TCT is 4.3 milliseconds and for central pathways supplying the lower limbs TCT is 9.3 milliseconds. This technique of central motorpathway assessment can be used to define the magnitude of a central motor deficit in neurological diseases affecting the corticospinal tract, during surgical procedures involving the spinal cord and in comatose patients. The new magnetic stimulation is painless and will probably widen the utilization of this method.

Electric Conductivity↗
PubMed1987

Central motor conduction in motor neuron disease.

Central motor conduction was assessed in 13 patients with motor neuron disease and in 15 control subjects. All patients with motor neuron disease, even those without clinical pyramidal signs, had slowed central motor conduction, and in some the delays were asymmetrical. Evoked motor potentials represent a new and reliable method to detect physiological abnormalities of central motor pathways early in the course of motor neuron disease.

Action Potentials↗
PubMed1983

[Recurrent familial hyperparathyroidism. A propos of 7 adenomas in 3 members of the same family. Review of the literature].

Over a period of 23 years, 3 members of a family of 5 presented with 7 parathyroid adenomas (4 in the first case, 2 in the second case, 1 in the third case). Excision of each adenoma, with systematic pre-operative assessment of the remaining parathyroid tissue, led to complete clinical and laboratory cure of each episode. The delay in the appearance of recurrence was between 3 and 9 years. After reviewing the literature, the authors stress the importance, in any case of hyperparathyroidism, of routinely investigating the serum calcium levels in members of the patient's family, especially if the patient is young and if he has had several episodes or multiglandular involvement in one episode. The authors discuss the literature concerning recurrent familial hyperparathyroidism with endocrine polyadenomatosis and the "hypercalcaemia-hypocalciuria" syndrome.

Adenoma↗
PubMed1983

[Familial and recurrent hyperparathyroidism. Apropos of 7 adenomas in 3 members of the same family. Review of the literature].

Over a period of 23 years, 3 members of a family of 5 presented with 7 parathyroid adenomas (4 in the first case, 2 in the second case, 1 in the third case). Excision of each adenoma, with systematic pre-operative assessment of the remaining parathyroid tissue, led to complete clinical and laboratory cure of each episode. The delay in the appearance of recurrence was between 3 and 9 years. After reviewing the literature, the authors stress the importance, in any case of hyperparathyroidism, of routinely investigating the serum calcium levels in members of the patient's family, especially if the patient is young and if he has had several episodes or a multiglandular involvement in the one episode. The authors discuss the literature concerning recurrent familial hyperparathyroidism with endocrine polyadenomatosis and the "hypercalcaemia - hypocalciuria" syndrome.

Adenoma↗
PubMed1983

[Value of dapsone in the treatment of Horton's disease and rhizomelic pseudopolyarthritis].

The authors report two cases of Horton's disease and one case of rhizomelic pseudopolyarthritis treated initially with delta-cortisone with a very rapid favourable result. However, while under relatively high dose steroid therapy, there was recurrence of the disease in the three cases and the development of complications of steroid therapy prohibited the use of higher doses of delta-cortisone and even required its rapid weaning. In these three cases, the addition of 100 mg of dapsone per day led to a rapid control of the disease, with return to normal of the erythrocyte sedimentation rate and reduction of the doses of delta-cortisone. The authors discuss the place of dapsone in the treatment of Horton's disease and rhizomelic pseudopolyarthritis in the light of these three cases.

Aged↗