Biomedical subjects
Publications and source records attributed to F Tanner.
Dakin's solution and a chloroxydizer in a hypertonic sodium chloride solution were tested for bacteriological and clinical effectiveness and stability. No real difference in effectiveness was observed between the two products; however, only the chloroxydizer showed satisfactory stability at 150 days under the test storage conditions.
25 cases (14 adults, 11 neonates) of Listeria monocytogenes infection were observed during a 15-month period (1983/1984) at the University Medical Center (CHUV) in Lausanne (Switzerland), in contrast to a mean of only 3 cases per year during the period 1974-1982. Eleven of 14 adults had neuromeningeal disease (3 meningitis, 7 meningoencephalitis, 1 encephalitis), and 3 patients had septicemia, two of whom were pregnant women. Among 8 adults with CNS parenchymal infection, 6 had involvement of the brainstem (rhombencephalitis), none of whom had an underlying disease characteristically predisposing to L. monocytogenes infection. Prominent clinical features in all patients with neuromeningeal disease included altered consciousness, headache and fever, and in 7 out of 8 patients with parenchymal CNS involvement an influenza-like illness was present prior to the development of neurological symptoms. Among the neuromeningeal cases the mortality rate was 45% (5 of 11), and 4 out of 6 survivors had severe neurological sequelae. During this 15-month period L. monocytogenes had become the leading cause of adult bacterial meningitis in this hospital. This is the first report on epidemic listeriosis in Switzerland, although sporadic cases have been described for 20 years. In contrast to previous years, analysis of the seasonal variation of the cases shows a peak of L. monocytogenes infections during the winter months of 1983/84. The high incidence of human listeriosis was not associated with an increase in animal cases. The human cases were uniformly distributed over the area, apparently in relation to population density.(ABSTRACT TRUNCATED AT 250 WORDS)
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Staphylococcus aureus isolated from purulent material has been systematically submitted to seroagglutination by Pillet's method as from 1972 to 1976. 495 serotyped strains from 333 patients are considered in the spread of infection. Epidemiological incidence and antibiotic resistance of each serotype is evaluated. As a result a new approach has been introduced in the operating theatre and in the wards. Hospital serotypes tend to disappear and new serotypes appear less virulent.
The results of the analysis of the neutralizing antibodies measured at days 30 and 90 after vaccination are described in brief. Different lots of Mérieux vaccine were used, of which two were checked separately for relative antigenic value by the Federal Public Health Service (CH). The lowest antigenic value (lot 0420 M) was 1.6 in relation to the standard NIH vaccine No.182. The inhibiting effect of immune globulin was shown to be significant with this lot, but not with the other, more powerful lots. The attention is drawn to isolated cases which did not present antibodies--or not a sufficient count--on days 30 or 90 according to the RFFI test.
Use of the Celster ISOP integral enclosure method in over 200 bone and joint operations prompts the following conclusions: With ISOP contamination of the surgical field is significantly reduced and the number of discharging wounds after surgery is lower. Delicate operations such as internal fixation of the fractured acetabulum or reinsertion of the cruciate ligament pose few problems under ISOP. The use of ISOP during bone and joint surgery is an advance in the prevention of postsurgical infection.
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