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F Tavarela Veloso

Publications and source records attributed to F Tavarela Veloso.

11 recordsLinked to original sources
PubMed2006

Dopamine D2 receptor polymorphisms in inflammatory bowel disease and the refractory response to treatment.

Dopamine and its receptors may be involved in inflammatory reaction. The availability of this molecule depends on its receptors. The DRD2 gene, which codifies for the D2 dopamine receptor, has several polymorphisms. In this study, the DRD2 TaqIA polymorphism, which confers a decreased receptor density, was evaluated in 313 individuals including 220 inflammatory bowel disease patients (143 patients with Crohn's disease and 77 with ulcerative colitis) and in 93 healthy blood donors. The analysis was carried out by PCR-RFLP techniques. The frequencies of A (1) A (1) and A (2) A (2) genotypes were similar among Crohn's disease, ulcerative colitis patients, and health controls. Also, the genotype frequency was similar in different groups of disease localization, behavior, and age of disease onset. However, the Crohn's disease patients carriers of A (2) A (2) genotype showed a lower risk for development refractory Crohn's disease (37 out 65) than A (1) A (1) and A (1) A (2) carriers (28 out of 65) [(OR=0.4, 95% CI 0.21-0.87; p=0.02)]. Our results support an involvement of the dopamine receptor in inflammatory bowel disease and suggest a new potential target for therapy in refractory Crohn's disease patients.

Adolescent↗
PubMed2004

Review article: skin complications associated with inflammatory bowel disease.

Cutaneous manifestations are well-recognized complications of Crohn's disease and ulcerative colitis. The incidence of these manifestations varies widely but, at the time of diagnosis, the mean incidence is around 10%. During the course of the disease, a great variety of skin lesions may develop, many of which are secondary to granulomatous cutaneous disease, reactive skin eruptions, nutritional deficiency and other associated conditions. The disorders that are directly related to the inflammatory process of Crohn's disease include perianal and peristomal ulcers and fistulae, metastatic Crohn's disease and oral granulomatous lesions. Histologically, the features are similar to those found in the inflamed bowel. These lesions usually respond to treatment of the underlying intestinal disease. The most common forms of reactive skin eruption are erythema nodosum and pyoderma gangrenosum. Certain subsets of patients are more susceptible to the development of erythema nodosum; in a previous report from our group, erythema nodosum was seen mainly in females, and in patients with colonic involvement and/or arthritis. This manifestation tends to occur during the first 2 years of the clinical course of the disease and may recur in approximately one-half of cases. Infliximab is highly effective in healing refractory lesions of erythema nodosum and pyoderma gangrenosum. Manifestations that are secondary to nutritional deficiency or associated conditions include acrodermatitis enteropathica, psoriasis and autoimmune disorders. For most of the cutaneous manifestations, the primary therapeutic target remains the bowel. Early aggressive therapy can minimize severe complications and maintenance treatment may prevent some devastating consequences.

Colitis, Ulcerative↗
PubMed2002

Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease.

The present study was aimed at evaluating the extent of dysfunction of the enteroendocrine and enteric nervous system, as indicated by changes in tissue levels of monoamines (dopamine, DA; norepinephrine, NE; 5-hydroxytryptamine, 5-HT) and their precursors and metabolites in the colonic mucosa of patients afflicted with ulcerative colitis (UC, N = 21) and Crohn's disease (CD, N = 22). In CD, but not in UC, NE tissue levels in both the noninflamed and inflamed colonic mucosa were markedly lower than in control subjects (N = 16). In the inflamed mucosa of CD and in UC patients levels of L-DOPA were twice those in controls. DA levels in the inflamed mucosa of CD and UC patients were markedly lower than in controls. This resulted in significant reductions in DA/L-DOPA tissue ratios, a rough measure of L-amino acid decarboxylase activity. 5-HT levels in the inflamed mucosa of CD and UC patients were markedly lower than in controls. In conclusion, intestinal cellular structures responsible for the synthesis and storage of DA, NE, and 5-HT may have been affected by the associated inflammatory process in both CD and UC.

Colitis, Ulcerative↗
PubMed1989

Inflammatory bowel disease in Oporto. A prospective hospital study.

Since 1975, 375 patients with inflammatory bowel disease (IBD) in Oporto have been studied; 180 had ulcerative colitis (UC) and 195 had Crohn's disease (CD). The steady rise in the number of patients observed suggests that the incidence of IBD is rising in the north of Portugal. At diagnosis UC was mild or moderate in 75.5% of patients, and 40.5% had rectal affection only. Colectomy was done only in two cases. The mortality was 1.1%. Clinical experience suggests that the behaviour of UC in this community may be milder than that reported at other centres. In CD patients ileitis was the commonest form (44.1%), and at diagnosis surgery was required for an acute condition of the abdomen in 22.5% of cases. The main complications were abdominal fistulae (22.1%) and perianal fistulae (21.5%). Colitis-related extraintestinal complications were present in 33.3% of IBD patients.

Colitis, Ulcerative↗
PubMed1982

Mast cells in Whipple's disease.

Abundant degranulating mast cells were observed during an ultrastructural study of jejunal biopsy from an untreated patient with Whipple's disease. Some of these cells were observed in intimate contact with macrophages containing bacteria in various stages of disintegration. Thereafter bacilli were often seen within the cytoplasm of mast cells, enclosed within vacuoles. These findings are suggestive of a cooperation between mast cell and macrophage in the defence of the organism against Whipple's bacillus.

Cytoplasmic Granules↗