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F Tost

Publications and source records attributed to F Tost.

29 records · Page 2Linked to original sources
PubMed1999

[Venous branch occlusion due to APC resistance].

OBJECTIVE: Resistance against the anticoagulatory effect of activated protein C (APC) is the most common genetic risk factor for venous thromboembolism. In the industrialized nations, the prevalence is 4-7% of heterozygous symptom carriers and 0.04% individuals with homozygous defect. The hereditary form is conditioned by a single-point mutation in factor V gene, whose molecular characterization became available in 1994. The fact that so far there are no reports about this specific disease in the German literature signifies a lack in the diagnosis of thromboembolic diseases. PATIENT AND METHODS: For this reason, the disease process of a 43-year-old female patient is reported. The woman came to this hospital for the first time in 1989 presenting a retinal branch vein occlusion. Her history revealed that she had taken hormonal contraceptives. The etiology of the thromboembolism remained unknown. The patient returned in 1997 because of recurrent retinal bleedings. The laboratory data indicated activation of coagulation (APC ratio 1.4). The following molecular characterization confirmed the mutation G 1691 A in factor V gene and the presence of thrombophilia. The ensuing examination of her family for thrombophilia identified one asymptomatic defect carrier among the patient's three children. Alternative methods of contraception were recommended to that daughter to prevent a even higher thrombotic risk and life-threatening complications. CONCLUSION: APC resistance seems to be a cause of retinal venous thrombosis in patients younger than 50 years. In patients in whom a familial thrombosis is suspected, the molecular genetic test for factor V Leiden should be obtained. There are no simple methods for the classification of the risks. The etiology of vascular diseases often remains unknown. Therefore it is important in special cases with typical history to keep in mind the APC resistance. Specialized anticoagulative therapy and familial prophylaxis depend on teamwork between ophthalmologists and hemostasiologists. This is decivise for the prevention of blindness.

Activated Protein C Resistance↗
PubMed1998

[Toxocara canis infection. Environmental parasitologic and epidemiologic studies].

UNLABELLED: Due to the large number of differential diagnostic possibilities, the etiology of endogenous uveitis is still hard to determine. One reason for uveitis may be the occurrence of parasites. However, too little attention is paid to this underlying disease. METHODS: To identify certain sources of infection, ovoscopic probes of 98 dog feces from the urban area of Halle were taken. The material was collected from children's playgrounds, parks and swimming pools. A retrospective analysis of patient case data from the records of the University Eye Hospital for the years 1986-1995 complemented the environmental and parasitological examination of patients with Toxocara canis and T. cati infections. RESULTS: From the ovoscopic examinations, 16% of the fecal samples contained T. canis eggs. Seventeen percent contained coccicidal sporocysts. Eggs of Trichuris vulpis and not clearly identifiable nematodal larvae were found in 1% of the samples. The reasons for the morphology was, in one instance, suspected Echinococcus eggs. The fact that 12 or 15 parasitologically positive dog excrement samples were taken from the immediate vicinity of children's playgrounds and another three directly from these grounds should be regarded as particularly critical. The investigated patient case data records revealed for the period studied nine uveitic patients with T. conis infection. The diagnosis was based on the larva precipitation test in all cases. After correct diagnosis and appropriate treatment, the prognosis was favorable. The specific treatment had to be repeated in two patients. CONCLUSIONS: The environmental parasitological study presented proves the relatively high prevalence of pathogenic causal agents in dog excrement samples from the area of urban recreation and leisure grounds, in particular, children's playgrounds. Parasite infestation is a mirror of the efficiency of hygienic and social measures. Public health education must be reinforced. Differential diagnosis of chronic endogenous eye diseases must pay more attention to infections by parasites.

Adult↗
PubMed1998

Electrophysiologic and echographic findings with choroidal osteoma.

The explanation by differential diagnosis of pathological changes of the fundus may be particularly difficult in case of diseases of sporadic occurrence. The examination findings in a 19-year-old patient with a choroidal osteoma are presented. Large arciform, atrophic areas with distinct boundaries and star-shaped vascular structures were dominant in the fundus on both sides. With peripapillar manifestation, the optic nerve head was ophthalmoscopically noncontributory. A submacular bleeding had caused sudden reduction of visual acuity and caused the patient to visit the ophthalmologist. The most important diagnostic key was supplied by echography, which established peripapillar scleral calcification. The posterior eye segment was highly reflective in ultrasonic echography (B mode), showing concave deformation and causing the sound shadow. Visually evoked potentials indicated the onset of the compression of the optic nerve by the choroidal osteoma. Diagnostic and treatment possibilities are discussed.

Adult↗
PubMed1996

[Wyburn-Mason syndrome].

BACKGROUND: There are various malformations of retinal vessels. Some of them are associated with cerebral vascular anomalies. MATERIALS AND METHODS: This report is given on a girl 6 years of age with a retinal racemose angioma. RESULTS: The clinical examination showed a unilateral racemose angioma combined with retinachorioidal anastomosis and a hemifacial vascular malformation. We found teleangiectasia in this area. The ophthalmoscopy demonstrated a blurred border of optic disc on the right eye with forward protrusion of the disc about + 2.0 dioptres. Large racemose lesions may be localized to the optic nerve and may involve segmental areas of the macula. The ultrasound showed a papillary stasis with highly reflective structures. The ultrasonic patterns are interpreted as a cholesterosis or fibrovascular tissue. This findings may belong to the rare Wyburn-Mason syndrome. Acute neurological symptoms by similar lesions the midbrain and hemorrhages during extraction of teeth are reported in literature.

Child↗
PubMed1995

Aqueous flare measurement with a laser flare cellmeter in eyes with diabetic retinopathy.

Eighty-one patients (147 eyes) with non-proliferative or proliferative diabetic retinopathy were examined with a laser flare cellmeter with regard to function of the blood-anterior chamber barrier. The protein content of the aqueous in patients with proliferative diabetic retinopathy was significantly higher than that in patient with the non-proliferative form. A statistically significant association was found between the age of diabetic patients and the flare concentration. In the group with non-proliferative diabetic retinopathy, a distinct increased flare concentration was measured in particular cases. Long-term controls will have to show whether this is an indication of imminent complications.

Adult↗
PubMed1992

[Arthur von Hippel--100 years motorized trepanation].

The introduction of a new motorized trepan in ophthalmic surgery by Arthur v. Hippel in 1891 was a very important achievement. The corneal incision became much safer and the unintentional injury of the iris, the lens and the vitreous body could be avoided considerably. Following a statement on corneal grafting in the 2. part of the 19. century the development of the trepan, the technical data and the experiences and reactions of other ophthalmic surgeons are discussed. The innovations of Arthur v. Hippel were appreciated by the A. v. Gräfe-Prize of the Society of Ophthalmology/Heidelberg.

Corneal Transplantation↗
PubMed1990

[Normogenesis of the cornea and its modification by cyclophosphamide in the animal experiment].

Animal experiments serving as models have hitherto been indispensable in order to explain pathogenetic processes in the development of malformations. The results presented here are contribution to studies on the normogenesis of the cornea in defined animal material (albino mice of Agnes Bluhm Jena-Halle stock). A single application of cyclophosphamide during embryogenesis caused inhibition malformations. Of these, different degrees of corneal hypoplasia and Peters' malformation are discussed in detail.

Abnormalities, Drug-Induced↗
PubMed1990

[Peter's anomaly in animal experiments].

Histopathological examinations were performed in 193 embryos of mice; Peters's anomaly was found in 2 cases. The authors discuss various theories of formation of this developmental defect and oppose them their own formulation.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Differential diagnosis of rapidly growing tumors--granuloma teleangiectaticum sive pyogenicum].

A clinicopathologic study of a granuloma telangiectaticum is reported in 37 year-old-woman. The tumor has a reddish to white colorit. Its rapid growth, within 2 weeks and appearance as well as clinical examination suggested a neoplastic process (squamous cell carcinoma). The patient had no trauma or surgery. The histopathological examination revealed a granuloma telangiectaticum. Local excision was curative.

Adult↗