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F Trunzo

Publications and source records attributed to F Trunzo.

4 recordsLinked to original sources
PubMed1987

Effect of aging on monoamines and their metabolites in the rat brain.

Concentrations of dopamine (DA), norepinephrine (NE), serotonin (5-HT) and their acid metabolites were assayed in specific brain areas of Wistar rats of various ages. DA and its metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) were significantly lower in striatum and mesolimbic areas of old (24 mos) rats than young adult (3 mos), but not mature (12 mos) rats. The decrease of homovanillic acid (HVA) was significant in mesolimbic areas but not in striatum. Neither cortical NE nor its metabolite methoxyhydroxyphenylglycol sulphate (MHPG-SO4) were significantly changed by aging. 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in the brainstem showed a tendency to a decrease and increase respectively in aged animals compared with young adults, but the differences were not statistically significant. However, the ratio of 5-HIAA to 5-HT concentrations was significantly higher in aged animals. The conclusion can be drawn that, in these brain areas, DA is more vulnerable to aging than NE and 5-HT, the metabolism of the latter being even enhanced.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1986

Brain dopamine autoreceptors in aging rats.

The function of dopamine (DA) autoreceptors is evaluated in vivo in striatum and mesolimbic regions of young adult (4 months), mature (14 months) and old (26 months) male Wistar rats. gamma-Butyrolactone (GBL)-induced dihydroxyphenylalanine (DOPA) accumulation in rats also treated with an inhibitor of aromatic L-aminoacid decarboxylase was used to determine the presence of synthesis-modulating nerve terminal autoreceptors while its reversal with apomorphine served as an index of autoreceptor stimulation. GBL-induced DOPA accumulation in striatum is very high at all three ages (130-150% increase in comparison with controls) as is its reversal by apomorphine (65-80% decrease in comparison with GBL alone). In mesolimbic regions, GBL has much less effect than in striatum (31% rise at 4 and 26 months, 12% rise at 14 months), but apomorphine's effect is of the same order of magnitude (down 60-80%). The conclusion can be drawn that aging does not significantly affect DA autoreceptor function in striatum and mesolimbic areas.

Aging↗
PubMed1985

Brain catecholamine content and turnover in aging rats.

The content and turnover of catecholamines were evaluated in various brain regions of young adult (4-months) and aged (24-months) male rats. Turnover was assessed from the concentrations of acid metabolites and the decline of catecholamine content after synthesis blockade with alpha-methyl-p-tyrosine. Dopamine was reduced by aging in striatum, mesolimbic areas, and hypothalamus. Dopamine metabolites and turnover rate were significantly lower in striatum and mesolimbic areas of aged than of young animals. Hypothalamic norepinephrine content and turnover rate were unchanged in aged compared to young rats but its metabolite (MHPG-SO4) was increased in the cortex. These findings point to an extensive impairment of brain dopamine metabolism in aging rats, whereas norepinephrine seems to be less impaired.

3,4-Dihydroxyphenylacetic Acid↗