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F U Huwez

Publications and source records attributed to F U Huwez.

14 recordsLinked to original sources
PubMed2003

A patient with reversible pupil-sparing Weber's syndrome.

This is a case report of a lady who presented with pupil-sparing Weber's syndrome. She had left oculomotor nerve palsy with normal pupil and right hemiparesis. The patient subsequently made a good recovery. An ischemic lesion of the lower mid-brain was demonstrated on the MRI scan of the brain, which corresponds to the motor nucleus of the oculomotor nerve. The article also describes the neuroanatomy of the oculomotor nerve and how its partial lesions lead to sparing of the pupil. In addition, this case report documents that a pupil-sparing Weber's syndrome could be reversible.

Aged↗
PubMed1998

Digoxin use in patients awaiting heart transplantation for systolic left ventricular failure.

We reviewed the drug therapy of 83 patients who underwent cardiac transplantation for chronic left ventricular cardiac failure in Scotland from 1992-1996. Digoxin had been prescribed to 52% of patients in sinus rhythm, and 82% of those in atrial fibrillation (P=NS). This audit confirms that, in line with the clinical practice in the period between 1992 and 1996, digoxin was not widely used in patients with advanced chronic heart failure who were in sinus rhythm. The publication of the withdrawal trials in 1993 might have been expected to increase the use of digoxin but this could not be demonstrated. The management of patients on the cardiac transplantation waiting list should include the best symptomatic treatment possible. In view of the clinical and experimental evidence of symptomatic improvement by cardiac glycosides, it is to be hoped that publication of the results of the Digitalis Investigation Group trial will improve this situation.

Adult↗
PubMed1997

Osteonecrosis of the calcaneum in a heart transplant recipient.

Avascular necrosis affects 3% of transplant recipients. In the lower limb, the femoral heads or condyles may be involved. We report the hitherto unrecorded complication of avascular necrosis of the calcaneum. Conservative management resulted in resolution without long-term complications.

Adrenal Cortex Hormones↗
PubMed1997

Histologically diagnosed Helicobacter pylori in heart transplant recipients.

BACKGROUND: The role of Helicobacter pylori in the pathogenesis of nonautoimmune gastritis and peptic ulceration is well recognized. H. pylori is widely prevalent in the general population, but the incidence among heart transplant recipients has not been reported. Furthermore, the natural history of this infection may be modified by immunosuppression. METHODS: Gastric and duodenal biopsy specimens from 47 heart transplant recipients were examined over a period of 44 months. RESULTS: Twenty-three (49%) patients had H. pylori infection (15 men, 8 women; mean age 49 [range 35 to 59] years). Eight of the 23 (35%) had symptoms. These eight patients were treated for H. pylori with bismuth, metronidazole, and amoxicillin, followed by maintenance H2-receptor antagonists. Dyspepsia continued in six of these patients, with persistence or recurrence of H. pylori being demonstrated in four. CONCLUSIONS: This study shows that although histologically diagnosed H. pylori infection is widely prevalent among heart transplant recipients, this prevalence is very similar to the general population. Immunosuppression may play a role in the recurrence or persistence of this infection and may diminish the mucosal inflammatory response to the organism.

Adult↗
PubMed1996

Infective dyspepsia in a heart transplant recipient.

We report the coexistence of symptomatic viral, bacterial, and fungal infection of the upper gastrointestinal tract in a heart transplant recipient. Endoscopic findings were normal at all levels but, because of severe symptoms and recent conversion to positive serology for Cytomegalovirus, biopsies were taken. These showed esophageal candidiasis and gastric Helicobacter infection that has hitherto been unreported in cardiac transplant recipients.

Anti-Bacterial Agents↗
PubMed1994

Age and body surface area related normal upper and lower limits of M mode echocardiographic measurements and left ventricular volume and mass from infancy to early adulthood.

BACKGROUND: M Mode echocardiograms can be measured by two different conventions. In addition, normal limits of echocardiographic measurements have customarily been stratified according to age or body surface area. There is therefore a need to develop a more easily managed approach to calculating normal limits of measurements for the two conventions, one of which, the Penn convention, has not previously been used for echocardiographic measurements in children. METHODS: M mode echocardiograms were recorded in 127 healthy subjects aged from 7 months to 19.5 years. Measurements were made from paper recordings according to the recommendations of the American Society of Echocardiographers and those of the Penn convention. RESULTS: Age and body surface area were found to be highly correlated; but for completeness separate age dependent and body surface area dependent equations for the normal limits of M mode echocardiographic variables were developed. CONCLUSION: A set of age dependent equations and a set of body surface area dependent equations are presented for easy calculation of upper and lower limits of normal M mode echocardiographic variables in infants and children.

Adolescent↗
PubMed1992

A new classification of left ventricular geometry in patients with cardiac disease based on M-mode echocardiography.

M-mode echocardiograms of 202 cardiac patients were studied with respect to the pattern of left ventricular (LV) geometry. Patients with normal LV mass and volume were separated from those who had LV hypertrophy or enlargement on the basis of LV mass and volume indexed to body surface area. The relative wall thickness that is currently used to classify LV hypertrophy/enlargement was found to be inadequate for differentiating between concentric and eccentric types of LV hypertrophy. A new M-mode echocardiographic classification is therefore proposed that accurately separates the different types of LV enlargement; it also allows identification of patients who have chronically dilated left ventricles at the expense of thin walls and thus have normal LV mass.

Cardiomegaly↗
PubMed1992

Variable patterns of ST-T abnormalities in patients with left ventricular hypertrophy and normal coronary arteries.

BACKGROUND: Classically, the ST-T configuration in the electrocardiogram of patients with left ventricular hypertrophy is said to have a typical pattern of ST depression together with asymmetrical T wave inversion (the so-called left ventricular strain pattern). However, many patients with left ventricular hypertrophy may also have ischaemic heart disease. To revise the electrocardiographic criteria for left ventricular hypertrophy the ST-T configuration in patients with left ventricular hypertrophy documented by echocardiography and with normal coronary arteries was assessed. METHODS: 24 patients were selected for this study. All had left ventricular hypertrophy documented by echocardiography, normal coronary arteries by cardiac catheterisation, and ST and/or T wave abnormalities in the lateral leads of their electrocardiogram. There were eight patients with aortic valve disease and 16 with hypertension who had coronary angiography as part of an investigation into the risk factors of sudden cardiac death caused by hypertensive left ventricular hypertrophy. No patient was receiving digitalis preparations or had electrolyte disturbances, and none had a previous myocardial infarction or ventricular conduction defect. RESULTS: Typical electrocardiographic evidence of left ventricular strain was found in approximately two thirds (63%) of patients and 95% of this subgroup had asymmetrical T wave inversion. Flat ST segment depression, with or without T wave inversion or isolated T wave inversion (symmetrical or asymmetrical) in the anterolateral leads, was seen in the remaining 37% of patients. CONCLUSIONS: These findings indicate that left ventricular hypertrophy without coronary artery disease can cause variable types of ST-T abnormalities in the anterolateral leads including the typical left ventricular strain pattern and non-specific ST-T changes. Non-specific abnormalities could not be distinguished from those of coronary artery disease and may adversely affect the accuracy of the electrocardiographic criteria for the diagnosis of left ventricular hypertrophy because they do not accord with the criteria for left ventricular strain.

Adult↗
PubMed1991

A comparison of left ventricular mass and volume using different echocardiographic conventions.

Left ventricular dimensions were measured on M-mode echocardiograms, both by the Penn Convention and the Recommendations of the American Society of Echocardiographers in a sample cardiac population. The measurements of interventricular septum and the posterior wall of the left ventricle were significantly larger (P less than 0.001) using American Society Recommendations compared to using the Penn Convention. However, the left ventricular internal dimension at end-diastole was significantly larger (P less than 0.001) when measured by the Penn Convention. As a result of the differences in left ventricular dimensions, the left ventricular mass indexed to body surface area was significantly higher (P less than 0.001) using American Society as opposed to Penn measurements. On the other hand, left ventricular volume indexed to body surface area was significantly higher (P less than 0.001) on Penn measurements than on American Society estimates. These differences should be considered in any study where criteria of normality are to be applied. Good positive correlation (r greater than 0.9) between Penn and American Society estimates of indexed left ventricular volume allowed development of a regression equation to convert volumes from one convention to another. As a result, an upper normal limit of 100 ml/m2 for indexed left ventricular volume is suggested for measurements made using the Penn Convention.

Cardiomegaly↗
PubMedDate not supplied

A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer.

A double-blind clinical trial was carried out on thirty-eight patients with symptomatic and endoscopically proven duodenal ulcer to compare the therapeutic responses to mastic (1 g daily, twenty patients) and placebo (lactose, 1 g daily, eighteen patients) given orally over a period of 2 weeks. Symptomatic relief was obtained in sixteen (80%) patients on mastic and in nine (50%) patients on placebo, while endoscopically proven healing occurred in fourteen (70%) patients on mastic and four (22%) patients on placebo. The differences between treatments were highly significant (P less than 0.01). Mastic was well tolerated and did not produce side effects. It is concluded that mastic has an ulcer healing effect, but further studies are needed to establish its role in treating peptic ulcer.

Adult↗