PubMed Health⌕ Search

Biomedical subjects

F V Rasmussen

Publications and source records attributed to F V Rasmussen.

At least 37 records · Page 2Linked to original sources
PubMed1989

Respiratory symptoms and FEV1 as predictors of hospitalization and medication in the following 12 years due to respiratory disease.

The predictive value of cough, mucus hypersecretion, breathlessness, chronic bronchitis and forced expiratory volume in one second (FEV1) for hospitalization and medication were examined in a random population sample of 876 men, 46-69 yrs of age. All of the men were examined in 1974 with interview and lung function tests. Information on hospitalization in the period 1977-1986 was obtained from the Danish National Patient Register, and information on drug usage was obtained from 567 men in a questionnaire survey ultimo 1985. FEV1 was a strong predictor of both hospitalization and medication. Respiratory symptoms were good predictors of hospitalization due to either respiratory disease in general (odds ratios 2.56-3.29), or chronic obstructive pulmonary disease (COPD), (odds ratios 4.16-5.75). They contained predictive values in addition to that provided by FEV1. Respiratory symptoms were good predictors of medication for airway obstruction, relative risks 3.56-4.70, and/or airway disease in general, relative risks 2.67-4.69. After controlling for FEV1, cough was still significantly associated with treatment for airway disease in general and both cough, mucus hypersecretion and chronic bronchitis were significantly associated with treatment for airway obstruction. We conclude that apart from FEV1, respiratory symptoms are independent predictors of hospitalization and medication due to respiratory disease.

Aged↗
PubMed1988

Should we continue using questionnaires on breathlessness in epidemiologic surveys?

The construct validity and ability to predict mortality on the basis of 4 British Medical Research Council (BMRC) questions on breathlessness were examined and compared to that of spirometric measurements, in particular FEV1, in a cohort of 1,045 men. Of these, 1,030 answered questions on breathlessness and 994 performed acceptable spirometry. Using 2 levels of dyspnea, white collar workers had significantly fewer symptoms of breathlessness than both cement workers and other blue collar workers, and this effect was present even after controlling for FEV1 as well as other spirometric measurements. We found an effect of age on dyspnea but not of smoking category. Furthermore, questions on breathlessness showed a dependence on extreme overweight. In a 10-yr follow-up, 219 men had died. Dyspnea Grade 3 or worse according to Fletcher's breathlessness score was a good predictor of overall mortality, yielding a mortality ratio of 1.57 for given occupation, smoking category, years with central heating, and overweight status, after controlling for FEV1. We conclude that in a standardized setting, questions on breathlessness provide a sensitive and objective tool. They contain information additional to that provided by FEV1 and other spirometric measurements.

Aged↗
PubMed1985

Occupational dust exposure and smoking. Different effects on forced expiration and slope of the alveolar plateau.

Indices of forced expiration (FEV1 and MEF25-75) were compared with the slope of Phase III of the single breath nitrogen test (%N2/1) in 1270 men, who, based on life occupational histories, were categorized as cement factory workers, blue or white collar workers, and farmers. The slope of Phase III was successfully determined in 1182 men. Irrespective of occupational category, the FEV1 and MEF was lower in present smokers than in ex-smokers, who in turn had lower values than never-smokers. With corresponding smoking habits, white collar workers showed on average higher values of FEV1 and MEF than the blue collar workers, the cement-exposed men and the farm workers. The slope of Phase III varied with smoking habits in a similar way, and among present smokers, the same occupational gradient was evident. However, no effect of occupation on the slope of Phase III could be traced in ex-smokers and never-smokers. It is concluded that the response of the lung to occupational exposure may differ from that of tobacco smoking. The combined use of indices from the forced expirogram and the slope of Phase III could yield valuable information in the study of occupational respiratory diseases.

Aged↗
PubMed1984

Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline.

In a double-blind cross-over study, including double-dummy placebo, 8 adult asthmatics received oral sustained-release proxyphylline 900 mg (Neofyllin retard) twice daily, or 250 mg microcrystalline theophylline (Nuelin) 4 times daily for 6 days. It was found that there was a reduction in the number of bronchodilatory aerosol dosages used with both proxyphylline treatment (139 dosages) and theophylline treatment (165) dosages, but only with proxyphylline was the difference in number statistically significant when compared with the placebo period (236 dosages, p less than 0.05). Subjective side-effects occurred significantly more often during theophylline treatment than during proxyphylline treatment (p less than 0.05). Changes in lung function after intravenous infusion of proxyphylline 1400 mg and aminophylline 400 mg confirmed the potency difference between the drugs. Volume of distribution and total body clearance were comparable for the two drugs. In 2 subjects, calculations of the fraction of drug absorbed and plasma-concentration versus time curves after oral and intravenous administration, suggested saturation kinetics of theophylline.

Administration, Oral↗
PubMed1982

Pulmonary function in patients with rheumatoid arthritis.

106 women and 38 men suffering from definite or classical rheumatoid arthritis underwent a pulmonary function test. The results were correlated to the duration and various clinical activity parameters of the disease. Pulmonary diffusion capacity was found to be reduced compared with the predicted values (p less than 0.05), irrespective of the duration or activity of the disease. The findings suggest that inflammatory vascular changes in the lungs usually occur in rheumatoid arthritis even in cases where other extraarticular manifestations can usually not be demonstrated.

Adolescent↗
PubMed1980

Pretreatment of exercise-induced asthma in adults with aerosols and pulverized tablets.

Eighteen adult asthmatics took part in a double-blind crossover study comparing the effect on exercise-induced asthma (EIA) of pretreatment with aerosolized 1) disodium cromoglycate (DSCG), 2) ipratropium bromide (IPTB), 3) fenoterol, 4) DSCG + IPTB and 5) saline. EIA was completely blocked by pretreatment with the beta 2-agonist, fenoterol. The protective effect of nebulized DSCG and IPTB given alone could not be distinguished from that of isotonic saline. The combination of DSCG and IPTB reduced the post-exercise bronchoconstriction more than any of the two drugs given separately. Thirteen of the 18 patients went on to a double-blind cross-over study of the effect on EIA of pretreatment with the usually recommended dosages off salbutamol, theophylline and their combination administered as pulverized tablets. Seven patients were withdrawn from this part of the study because of side-effects, and in the remaining six none of the oral pretreatments could be distinguished from placebo, despite serum theophylline concentrations within or above the commonly recommended therapeutical range.

Administration, Oral↗
PubMed1980

Evaluation of a method for determination of mean transit time of xenon-133 in the lungs.

The purpose of the study was to determine the mean transit time, t, for Xe-133 in the lungs and to compare the results with t for helium determined simultaneously by the helium-dilution technique. Thirteen normal subjects were studied, and four patients with pulmonary disease. No significant difference was observed between the mean transit times for Xe-133 and helium obtained in normal subjects during equilibrium as well as during desaturation. The mean washout time for Xe-133 during desaturation, rho a/h (calculated as the area under the desaturation curve divided by activity at equilibrium), was significantly longer than the mean transit time for He. Similar results were obtained in the patients. Thus it is possible to determine total ventilation per unit volume correctly when the initial washout rate is used, whereas calculations based on rho a/h underestimate V/V. Accordingly, rho a/h should not be used as equivalent to the mean transit time. However, rho a/h might give information of clinical value, especially in patients with chronic obstructive pulmonary disease.

Adult↗