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Biomedical subjects

F Val Bernal

Publications and source records attributed to F Val Bernal.

At least 19 recordsLinked to original sources
PubMed2004

[Acute cell rejection in ex vivo model of swine-human renal xenotransplantation].

OBJECTIVE: Ex vivo perfusion model of pig-to-human kidney xenotransplantation to evaluate human antiporcine xenograft rejection once hyperacute rejection (HAR) is avoided. METHODS: Pig kidneys were perfused for 3 hours with pig blood (group 1; n = 5), human blood (group 2; n = 5), complement heat inactivated human blood (group 3; n = 5), platelet-depleted human blood (group 4; n = 5); and xenoreactive natural antibodies (XNA)-depleted human blood (group 5; n = 5). Tissue samples were studied with immunoperoxidase techniques. RESULTS: Pig kidneys perfused with human blood, group 2, showed HAR with interstitial haemorrhage, vascular thrombi and glomerular injury. Pig kidneys perfused with manipulated human blood (groups 3 to 5) had no histologic evidence of HAR, but showed signs of acute cellular rejection with different degrees of interstitial infiltrate of mononuclear cells, specially in the XNA-depleted group. CONCLUSIONS: The model may be valuable in the isolated evaluation of the elements involved in the pig-to-human xenorejection. The depletion of complement, platelets and XNA protected porcine kidneys form HAR in our study and allowed the development of an acute cellular rejection, a very unusual fact in this short time, 3 hours.

Acute Disease↗
PubMed1995

[Bladder pheochromocytoma].

OBJECTIVES: The present study reports on a case of paraganglioma of the urinary bladder and briefly reviews the literature. METHODS/RESULTS: The patient presented with gross hematuria and no history of hypertension. The pathological findings were diagnostic of paraganglioma of the urinary bladder. CONCLUSIONS: Extra-adrenal pheochromocytoma is uncommon. Although it usually presents with typical symptoms, these are also determined by tumor location. Currently, there are no anatomopathological criteria to distinguish the benign from the malignant form.

Adult↗
PubMed1994

[Leiomyoma of the epididymis. Report of a case and review of the literature].

Leiomyoma of the epididymis is a benign tumor that is rarely diagnosed and is second only to epididymal adenomatoid lesions in frequency. A case of leiomyoma of the epididymis in a 62-year-old patient is described. The patient presented with a tumor in the tail of the left epididymis which was definitively diagnosed following surgical resection and subsequent anatomopathological analysis. The classification, clinical features, diagnosis and treatment of this tumor type are briefly discussed.

Epididymis↗
PubMed1993

[Carcinoma of Bellini's duct].

First case in the Spanish literature of a carcinoma of Bellini's duct. Differentiation of this tumor from the classic renal adenocarcinoma, mainly the papillary type, is based on the different embryological origin, microscopic characteristics and immunohistochemical studies. Prognosis is worse than for the other renal adenocarcinomas.

Adenocarcinoma↗
PubMed1993

Nuclear morphometry lacks prognostic value in squamous cell carcinoma of the oesophagus.

In order to determine the possible influence in oesophageal squamous cell carcinoma of nuclear measurements on patients' postoperative survival and on various histological tumour features, we performed a nuclear morphometry study on 53 patients (50 males, 3 females) with a mean age of 57.4 years (37-79). A statistical correlation was revealed between area, perimeter and diameter and the analysis was, therefore, performed only in terms of nuclear area. No influence of nuclear area on postoperative survival was observed. Nor was a relationship found between mean nuclear area and either involvement of the oesophageal wall or degree of histological differentiation. The tumours showing expansive growth had a larger mean nuclear area than those of the infiltrative growth type, although differences did not reach statistical significance. The nuclear area standard deviation (reflecting anisocytosis of the tumour) showed no correlation with survival. In conclusion, our data do not support that measurement of nuclear parameters by static methods is of any prognostic value in surgically-treated squamous cell carcinoma of the oesophagus.

Adult↗
PubMed1991

[Prognostic factors in 243 transitional carcinomas of the bladder (I): clinical and macroscopic parameters of the tumor].

A retrospective study was undertaken in 243 cases of transitional cell carcinoma of the bladder to determine the correlation of clinical parameters (sex, age, symptoms and duration of the disease) and tumor gross anatomic features (cystoscopic aspects, tumor number, size and site) with survival. The study comprised 148 superficial carcinomas and 95 infiltrating carcinomas of the bladder. The following clinical parameters were observed to influence survival of patients with superficial or deep tumors: patient age (worse prognosis for those over 60 years) and initial symptoms (better prognosis for those whose presenting symptom was hematuria). With regard to tumor gross anatomic features, a correlation was observed between the cystoscopic aspects of the tumor and type of infiltration in 80% of our series (1 error out of 5 cystoscopies). A worse prognosis was observed for multiple lesions only in those with superficial tumors. Tumor site and size did not influence survival in this series of 243 transitional cell carcinoma of the bladder.

Adult↗
PubMed1991

[Prognostic factors in 243 transitional carcinomas of the bladder (II): microscopic parameters of the tumor and staging].

A retrospective study was undertaken in 243 cases of transitional cell carcinoma of the bladder to determine the correlation of tumor microscopic features (mitotic index, histologic grade, internal border of tumor growth, lymphocyte infiltration, necrotic and vascularized areas) and stage with survival. The study comprised 148 superficial tumors (131 papillary, and 17 non-papillary) and 95 deep infiltrating tumors (34 papillary and 61 non-papillary or solid tumors). With regard to the superficial tumors, survival was influenced by the mitotic index (a greater number of mitoses correlated with a worse prognosis), histologic grade (a higher histologic grading correlated with a worse prognosis), internal border of tumor growth (the expansive tumor type showed a better prognosis), and necrosis (wide areas of necrosis correlated with a lower survival rate). Furthermore, a worse prognosis was observed for the non-papillary or solid tumors. Lymphocyte infiltration, however, was not observed to influence survival. As for the deep infiltrating tumors, survival was influenced by the histologic grade, internal border of tumor growth, lymphocyte infiltration (a greater lymphocyte infiltration correlated with a better prognosis), necrosis, and tumor type (papillary or non-papillary). The mitotic index or vascularization showed no influence on survival. A higher tumor stage correlated with a worse prognosis. The prognosis for non-papillary (solid) superficial tumors overlaps that of infiltrating tumors. For this reason, special attention should be focused to these tumors.

Adult↗
PubMed1991

[Morphometric study of transitional carcinoma of the bladder (I): analysis of 148 superficial tumors].

A morphometric study of the tumor cell nucleus was performed in 148 cases of superficial transitional cell carcinoma of the bladder. Of these, 131 were papillary and 17 were nonpapillary tumors. Our methodology is compared with those described elsewhere. With regard to papillary tumors, the nuclear size of the internal papilla near the stroma was found to be greater than that of the external papilla near the bladder lumen. Tumor cells with internal papillary nuclear size less than or equal to 28 microns 2 appeared to have a better prognosis. Thus, nuclear measurements in this area must be performed in future studies. No conclusive data could be obtained relative to the nonpapillary tumors. For both papillary and nonpapillary tumors, the higher the histologic grade, the greater the nuclear size, the differences being statistically significant.

Carcinoma in Situ↗
PubMed1991

[Morphometric study of transitional carcinoma of the bladder (II): analysis of 95 infiltrating tumors].

The nuclear size of 95 infiltrating carcinomas of the bladder were studied morphometrically. There were 34 of the infiltrating papillary type and 61 pure infiltrating tumors. The nuclear size was found to be greater deeper into the tumor. Similarly, the higher the histologic grade, the larger the nuclear size. Grade IV tumors, however, were not greater than grade III. The foregoing finding prompted us to classify grade IV tumors as undifferentiated rather than as transitional cell tumors. A better prognosis was observed for stage T2 and T3A tumors with a nuclear size less than or equal to 30 microns 2.

Carcinoma, Transitional Cell↗
PubMed1990

[Mitro-aortic endocarditis caused by Listeria monocytogenes].

A case of Listeria monocytogenes valvular endocarditis is reported. This patient required mitral and aortic valve replacement by Björk-Shiley mechanical prostheses. Patient clinical condition was progressively deteriorated, affecting the left ventricular function, increasing the size of vegetations and the presence of aortic annular abscess. This case represents the 48th reported in the literature and the third in our country. We here comment about the clinical aspects and the treatment of this infrequent entity.

Aortic Valve↗
PubMed1986

A new absorbable annuloplasty ring in the tricuspid position: an experimental study.

An absorbable bovine fibrin annuloplasty ring was implanted in the tricuspid position in 30 adult mongrel dogs to determine the rate of absorption and the effectiveness of this new method of annuloplasty. There were 4 early deaths. The remaining 26 dogs survived the operation and were electively sacrificed. The cumulative follow-up was 111.5 months (14 days to one year). Mean follow-up was 4.2 months per animal. Six dogs sacrificed between 2 and 4 weeks (group I) showed mild to moderate ring surface erosion and a fibrinous capsule covering the prosthesis. Nine out of 10 specimens showed total absence of the ring 1 to 2 months after surgery (group II), and all bovine fibrin tissue had disappeared in the 10 remaining dogs after 2 months of implantation (group III). In 2 cases small areas of chondroid degeneration were detected 4 months after surgery. This concept of a time-controlled biodegradable annuloplasty might be useful, although further studies are needed before its clinical application.

Absorption↗
PubMed1982

Hemiplegia and peripheral gangrene secondary to large and medium size vessels involvement in C.R.E.S.T. syndrome.

A woman with CREST syndrome since the age of 35, had 11 and 13 years respectively after her disease onset, two episodes of CVA with residual right side hemiplegia. The angiography revealed segmented stenosis in the left common carotid, right subclavian and left renal arteries. At the age of 49 she developed gangrene of the right foot, requiring below the knee amputation. Pathological examination of the surgical specimen, showed extensive intimal fibrosis of the vessel walls in large and medium size arteries. Involvement of large and medium size arteries is infrequent in scleroderma. The case described illustrates this severe and unusual complication.

Arteries↗