[Our experience in the secondary treatment of severe skin loss, using classical means].
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Biomedical subjects
Publications and source records attributed to F Vandenbussche.
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In patients with malignant melanoma, histiocytofibromas often appeared to be present. The frequency of this association has been determined in 60 female and 40 male patients, and compared with age- and sex-matched controls. Histiocytofibromas are significantly more common in females with malignant melanoma than in controls. This relationship is not found in males. Therefore, it would seem important to make a careful examination of nevocytic nevi in women having this benign tumour because of the high risk of developing a malignant melanoma.
This report attempts to clearly define the polymorphic nature of sequelae from burns of the lips by introducing a simple classification based on the direct or indirect, and minor, moderate, or major nature of the affection. Understanding of the processes involved in scar formation is essential for developing a rational plan for surgical repair. However, the ideal situation would be to prevent scar formation by fixation-compression, the use of an orifice shaper, or by excision-grafting of facial burns associated with these procedures.
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This work groups 126 cases of malignant melanomas operated since 1967. Seventy-seven cases responding to 2 criterions were selected: reexamination of the primary pathologic sample of melanoma according to 4 tests of histoprognosis and adequate follow-up of the patient. Histoprognostic criterions according to Clark and Mihm were the histogenetic type, the level of invasion plus vascular embolic neoplastic invasion and the notion of mitotic index. Four main conclusions emerged: Statistical notion of a critical period situated between the 12th and 30th month, during which 40% of patients die, especially those with primary tumor of histogenetic type NM (nodular melanoma) or SSM (superficial spreading melanoma) and invasion stage IV and V. Assurance of the value of histoprognosis in the primary cognition of tumoral determinism. A new precision in the decision of systematic node excision in invasion stages IV and V, and in stages III with high mitotic index. Reasonable and early use of all therapeutic means in cases with unfavourable histoprognosis.
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