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Biomedical subjects

F Veith

Publications and source records attributed to F Veith.

At least 19 recordsLinked to original sources
PubMed1987

[Value of drill-biopsy in breast cancer].

This study reports the results of 649 drill biopsies performed on breast tumors before any treatment. Diagnostic of malignancy was achieved with a drill biopsy in 89% cases (579/649 procedures). Pathological subtypes, i.e. common infiltrating types, special pathological types, were determined in 98% cases (566/579), while histo-prognostic grading, according to Scarff, Bloom and Richardson, was performed in 98% of the common infiltrating type carcinomas (498/507). Reliability of the technique was related to the tumor size 57%, 87.5%, 93.5% and 98.5% in T1, T2, T3 and T4 tumors (TNM classification), respectively. Comparative reliability of the three different operators was 86.5%, 88.5% and 92%, and was related to their technical experience. This study has demonstrated the diagnostic value of a "malignant" drill biopsy, which is independent of the results of the initial radiological and clinical work-up: suspicious or malignant (group A: 635 cases, or non-suspicious group B: 14 cases). However, "non malignant" drill biopsy has no value and should not be conclusive.

Biopsy, Needle↗
PubMed1985

Treatment of renal transplant rejection episodes in patients receiving prednisone and azathioprine. A cost-effective approach.

Antilymphocyte globulin (ALG) has been advocated for the treatment of renal transplant rejection episodes in patients maintained on prednisone and azathioprine. Treatment with steroids (outpatient) is considerably less expensive than with ALG (inpatient), so we studied whether routine ALG was necessary. Between 3/82 and 11/83, 54 cadaver transplant recipients maintained on prednisone and azathioprine who developed a first rejection episode were randomized to receive--for treatment of their first, and if necessary second, rejection--methylprednisolone (MP) plus ALG (n = 24), or MP alone, with ALG added if treatment failed (n = 30). Treatment failure was defined as continuing deterioration on T131 iodohippuran scan, rising serum creatinine level, or lack of improvement within 7 days. There was no significant difference in patient survival, graft survival, mean number of rejections, and infection rate between the two groups: 60% (18/30) of first and 50% (10/10) of second rejection episodes responded to MP alone. We conclude that patients are not penalized by initial rejection treatment with MP. Many rejection episodes respond to steroids alone; elimination of routine ALG use will save hospitalization time and expense.

Adult↗
PubMed1984

Effect of estradiol on nonmalignant human mammary cells in primary culture.

We have studied effects of estradiol on primary cultures of nonmalignant human mammary tissue collected surgically from fibroadenomas or during reduction mammoplasties. After enzymatic digestion, "organoids" made of epithelial cells organized in ductal or alveolar structure were grown in primary cultures (up to 12 days) on different substrata (glass, plastic, collagen-coated plastic, and floating collagen membranes). Transmission and scanning electron microscopy showed that these organoids were responsive to physiological concentrations of estradiol. Condensed chromatin of epithelial cells became dispersed following estrogen treatment. The plasma membrane of epithelial cells at the surface of the organoids was dramatically modified by estradiol, which increased the number and the length of the microvilli, as observed previously in the MCF7 breast cancer cell line (Vic et al., Cancer Res., 42: 667-673, 1982). This effect was not observed with the same concentrations of progesterone, dexamethasone, dihydrotestosterone, or 1 microM tamoxifen or in fibroblasts of the same tissue, demonstrating that epithelial mammary cells are specifically responsive to estradiol. By contrast, no effect of estradiol could be evidenced on the [35S]methionine-labeled proteins released into the medium by the organoids. The estrogen-regulated protein of Mr 52,000 was not found in the medium after purification by concanavalin A-sepharose or immunoprecipitation with specific antibodies to the Mr 52,000 protein from MCF7 cells. We conclude that nonmalignant mammary cells are responsive to estrogens in primary culture.

Adenofibroma↗
PubMed1983

[Prognosis of breast epithelioma detected by microcalcifications in the absence of a palpable tumor].

A retrospective study of 65 patients with unpalpable breast cancer revealed by microcalcifications on mammography showed that 18 had presented with infiltrating epithelioma. The contralateral epithelioma was revealed by mammography. Three deaths from metastases had occurred in this group. The 65 carcinomas discovered by mammography were treated by excision of the microcalcified area. This was followed by mammectomy in 34 cases and by irradiation in 25. Close surveillance only was suggested in 6 cases. Histological studies showed 6 lobular carcinomas in situ and 59 duct epitheliomas, 26 of which were infiltrating. The prognosis of isolated duct epitheliomas is highly favourable, and no dissemination was observed. The 2 local recurrences observed after secondary irradiation concerned infiltrating epitheliomas; these patients are now alive without sign of recurrence after mammectomy. After conservative treatment (tumorectomy followed by irradiation), no recurrence was observed among patients with non-infiltrating duct carcinomas.

Adult↗
PubMed1983

[Phyllodes tumors of the breast. Apropos of 83 cases].

Twelve recurrences after surgical treatment of 83 cystosarcoma phyllodes of the breast were reported. The histology of the initial tumor was benign (n = 73), borderline (n = 6), sarcoma (n greater than 4). Nine recurrences were observed at the initial site of the tumor (2 in another quadrant of the same breast and I in the contralateral breast). The cause of local recurrence is related to incomplete tumorectomy (n = I), pseudo-capsule infiltration (n = 3), micro-nodules satellites (n = 2). No etiology for recurrence was defined in 3 cases. The importance of a careful microscopic examination of the initial tumor is emphasized because the infiltration of the pseudo-capsule and the presence of micro-nodules satellites can only be recorded on correctly prepared slides.

Adolescent↗
PubMed1983

Release of estrogen-induced glycoprotein with a molecular weight of 52,000 by breast cancer cells in primary culture.

In an attempt to find estrogen-specific responses in breast cancer, we have established primary cell culture from metastatic pleural effusions of breast cancer and have analyzed the proteins labeled by [35S]methionine and released into the culture medium using sodium dodecyl sulfate-polyacrylamide gel electrophoresis. We show that the synthesis of a Mr 52,000 glycoprotein which is released by metastatic breast cancer cells in primary cultures is stimulated by estradiol in four of six patients. This protein is similar to the Mr 52,000 protein of MCF7 cells on the basis of its mobility in one- and two-dimensional gel electrophoresis [the molecular weight of this protein was originally found to be 46,000; it is closer to 52,000 using labeled proteins from New England Nuclear as molecular weight markers], its immunoprecipitation by antisera raised against the Mr 52,000 protein, and its binding to concanavalin A. We conclude that, similar to some breast cancer cell lines, some metastatic breast cancers synthesize a Mr 52,000 glycoprotein which is regulated by estrogens and exported from the cells into the medium. This study also shows that some primary cultures established from metastatic breast cancer remain responsive to estradiol in vitro for the synthesis of specific proteins. More clinical studies are needed to prove the interest of the Mr 52,000 secreted protein as an additional marker of the hormone responsiveness of breast cancer.

Breast Neoplasms↗
PubMed1982

Conservative treatment of axillary adenopathy due to probable subclinical breast cancer.

Eleven female patients were treated conservatively by radical radiotherapy to the breast and ipsilateral lymphatics for metastatic adenocarcinoma in an axillary lymph node without clinical or mammographic evidence of a breast cancer. Ten of 11, four of five, and three of four were alive and free of disease 5, 10, and 15 years later, respectively. Of the 11 patients who were followed up for a minimum of five years, three (27%) had local recurrences: one at six, one at 11, and one at 14 years. The latter two recurrences were salvaged by secondary mastectomy. The cosmetic results were excellent and no serious irradiation complications were observed. Mastectomy may not be needed for patients with axillary adenopathy due to a probable subclinical breast cancer, since the long-term prognosis after radiotherapy is good and salvage surgery can be performed if recurrences develop.

Adenocarcinoma↗
PubMed1978

[Surgery for carcinoma of the cervix: frozen section examination of the external iliac nodes (author's transl)].

Since 1970, the authros have carried out colpohysterectomy with external iliac node dissection for carcinoma of the cervix at stages 1 and 2. The nodes were subjected to frozen section histological examination. In the presence of signs of invasion, primary iliac block dissection is carried out. Two hundrend and seventy cases have been treated in this way, with only 7 cases of error in the frozen section diagnosis (2,5%). There was 1 false positive, 4 false negatives and 2 doubtful cases with a suspicion of invasion. It is therefore suggested that frozen section histological examination of the external iliac nodes is possible and reliable.

Adult↗
PubMed1977

[Breast cancer: histological prognosis from biopsy material].

Two histological factors to be taken into consideration for prognosis in pretreatment schedules of breast cancer have been studied on a group of 352 cases treated by non-mutilating therapeutics at the Fondation Curie between 1960 and 1970. The tumour material the slides of which we have reexamined "blindly", i.e. ignoring the evolution of the case had been obtained mostly by drill-biopsy. Histological groups and types have been determined following an analytical classification for computer purpose. The degree of malignancy was calculated with the method of Scarff-Bloom-Richardson. The analyzed data have been memorized on computer and then confronted with the elements of the T.N.M. classification and the survival of the patients involved. It appeared that if drill-biopsie have been performed correctly the histological type may be defined in eighty percent of cases. And it is likewise possible to calculate the histological grade of malignancy for each mammary cancer. With such a material the value for prognosis by means of the Scarff-Bloom-Richardson method still remains if applied only to adenocarcinoma of the "common infiltrating type".

Adenocarcinoma↗