[Obstetrical problems in breech presentation (proceedings)].
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Biomedical subjects
Publications and source records attributed to F W Dittmar.
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167 women were treated with 0.5 mg lynestrenol/day for a period of 8-32 weeks immediately postpartum. The lactation periods of 67 of the women were observed during the stay in hospital (maximum 7 days) in comparison with a control group (n = 20) of untreated women in the puerperium. There was no quantitative difference in milk production between the lynestrenol-treated women and the control group. In order to exclude a possible thromboembolic effect the lynestrenol the thrombocyte aggregation was determined in all women at 4-weekly intervals as a measure of a thrombotic tendency. During the entire period of the investigation the mean PAT rating remained between I and II. Among the clinical parameters a raised amenorrhea rate of 21% and a larger proportion (39%) of breakthrough bleedings were notable. The responded easily to treatment.
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Radio-immunologic measurement of alpha-fetoprotein is possible in small amounts of blood and amniotic fluid. During the first half of pregnancy the AFP values in maternal serum are lowered when there is fetal abnormality (hydatid cyst, immnent abortion). In the second half of pregnancy high values of AFP also indicate danger to the fetus (Rh-incompatibility). The older the pregnancy the AFP values in amniotic fluid fall. In pathologic pregnancy (hydramnion, anencephaly, trisomy) AFP concentration was normal or raised. Measurement of the AFP level in umbilical cord -- blood provides further diagnostic chances: assessment of the duration of pregnancy and, therefore, of fetal maturity.
This study confirms essentially the results of other investigators who found a good correlation between fetal risk and maternal AFP level. This adds an immuno-chemical technique to well-known methods of monitoring risk-pregnancies (ultra-sound, HPL, estrogenes) which enables us to measure a specific fetal metabolic product, alpha-feto-protein, in amniotic fluid, umbilical blood and maternal serum.