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F W Eichbaum

Publications and source records attributed to F W Eichbaum.

28 records · Page 2Linked to original sources
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Antiarrhythmic effect of solvents: propylene glycol, benzyl alcohol.

Propylene glycol and benzyl alcohol, the main constituents of most solvent vehicles, display a pronounced antiarrhythmic-antifibrillatory effects, when injected intravenously into animals (dogs, rats) with spontaneous or drug-induced arrhythmias. The antiarrhythmic dose for propylene glycol amounts to 0.2-0.3 ml/kg of a 70 per cent solution and, for benzyl alcohol to 0.2-0.4 ml/kg of a 4 per cent solution in physiologic saline, respectively. Similar effects were also obtained by the combined injection of propylene glycol + benzyl alcohol, in proportions which correspond to the formulae of numerous commercial "solvents" (vehicles): 2 to 20 per cent solutions of benzyl alcohol in 70 per cent propylene glycol (0.05-0.2 ml/kg). The mechanisms which might be responsible for the antiarrhythmic activity of solvents are discussed: lengthening of the effective refractory period, local and general anaesthetic effects, changes of osmolarity. The intravenous injection of propylene glycol and/or benzyl alcohol, in high doses, produces intravascular haemolysis. Clinical investigations are recommended as to the potential, beneficial or toxic effects of drug solvents, especially upon the cardiocirculatory system.

Animals↗
PubMedDate not supplied

Anticoagulants and cancer. A review.

Anticoagulants (heparin, warfarin, fibrinolysin and others) reduced incidence of cancer metastases by inhibiting the formation of a fibrin matrix indispensable for peripheral fixation of circulating cancer cells. Apart from their specific anticoagulant activity most of these substances interfere directly with cell growth and metabolism, stimulating also immunologic anticancer mechanism. In clinical cases, favourable results have been obtained in various forms of metastasizing cancer, and especially in Hodgkin's disease and leukemias, by combining anticoagulant and cytostatic treatment. The results observed in other forms of cancer, though promising, are still controversial. The potential dangers and side effects of anticoagulant treatment in cancer are discussed.

Anticoagulants↗