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Biomedical subjects

F W Lohmann

Publications and source records attributed to F W Lohmann.

11 recordsLinked to original sources
PubMed1979

[The influence of a combined diurectic-beta-receptorblocker therapy on elevated exercise blood pressures. Ergometric investigations in hypertensive patients (author's transl)].

In hypertensive patients physical exercise can induce considerable increases of blood pressure. This means particularly for elder patients a high risk of cardiovascular complications. Therefore we investigated in 13 elder patients suffering from arterial hypertension the effect of a hypotensive combined therapy with a diuretic and a beta-receptorblocker on elevated blood pressures during and after ergometric work. Apart from the reduction of the blood pressure at rest, especially the systolic and diastolic blood pressure during exercise was lowered significantly. In addition to a diuretic hypotensive therapy a beta-receptorblocker can be of great benefit also for elder patients particularly in order to reduce elevated exercise blood pressures.

Adrenergic beta-Antagonists↗
PubMed1979

[The influence of a long-term cardioselective and noncardioselective beta-receptorblockade on blood pressure, O2-uptake and carbohydrate metabolism. Ergometric investigations in hypertensive patients (author's transl)].

1. In 9 male hypertensives the influence of a long-term cardioselective (200 mg Metoprolol) and non-cardioselective (15 mg Pindolol) beta-receptor blockade on the blood pressure, O2-uptake and carbohydrate metabolism was investigated at rest and during a short (6 min, 100 Watt), long (30 min under steady-state conditions with a heart rate of 130/min) and maximal ergometric work and 5 min after that. 2. In this cross-over trial the blood pressure was reduced significantly (p less than 0.01) and in an identical manner by both beta-receptor blockers. 3. Though there was a significant (p less than 0.01) reduction of the heart rate of 26% by Metoprolol (M) and of 21.2% by Pindolol (P), the O2-uptake during submaximal work was unchanged under P with 1.66 +/- 0.4 l/min and under M with 1.7 +/- 0.44 l/min in comparison with the control (C) of 1.71 +/- 0.38 l/min. The maximal O2-uptake was insignificantly reduced by Pincolol (C 2.51 l/min; M 2.46 l/min; P 2.11 l/min). 4. Only under Pindolol we found in all patients a marked and insignificant (p less than 0.01) drop of the blood sugar level in the 30th min of ergometric work (C 76.2 +/- 11; M 72.6 +/- 9; P 55.3 +/- 11 mg/dl), under maximal work (C 74 +/- 12; M 73.2 +/- 10; P 54.2 +/- 11 mg/dl) and 5 min after (C 83.6 +/- 11; M 87.6 +/- 15; 69 +/- 19 mg/dl). 5. The lactic acid level showed under both beta-receptor blockers the same tendency to decrease. 6. The drop of the blood sugar to hypoglycemic values is due to an impaired glycogenolysis in the skeletal muscles and implies a considerable reduction of the physical capacity. Therefore the cardioselective beta-receptor blocker Metoprolol is recommended especially for the treatment of young hypertensives and for all patients who need their physical fitness in order to achieve their work or to perform a preventive and rehabilitative training.

Blood Glucose↗
PubMed1978

[Ergometry in the assessment of antihypertensive treatment (author's transl)].

A standardized ergometric test, suitable for recognizing abnormally high exercise blood pressures as well as the influence of hypotensive drugs on blood pressure, was employed in 13 of 28 hypertensives being treated with a combination of beta-receptor blockers (oxprenolol, 80 mg), a diuretic (chlortalidone, 10 mg), and a vasodilator (hydralazine, 25 mg). This combination was an effective antihypertensive measure with few side effects, particularly so in reducing elevated exercise blood pressures.

Adult↗