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Biomedical subjects

F W Maddux

Publications and source records attributed to F W Maddux.

6 recordsLinked to original sources
PubMed1991

Hypertension as a causative diagnosis of patients entering end-stage renal disease programs in the United States from 1980 to 1986.

Treatment of hypertension has decreased the incidence of stroke and congestive heart failure consequential to hypertension. To determine whether the incidence of hypertension as a causative diagnosis of end-stage renal disease (ESRD) is also decreasing, we examined the records of the Health Care Financing Administration (HCFA) from 1980 to 1986 regarding the causative diagnoses of patients entering ESRD programs. We found that the incidence of patients entering ESRD programs increased during the study period. Hypertension as a causative diagnosis was a constant proportion of the increase. The greatest increase occurred in patients age 55 or more years. This was strikingly true of black patients. We conclude that there has not been a decrease in the incidence of hypertension as a causative diagnosis for patients entering ESRD programs and that this may be a reflection that treatment of hypertension does not prevent the development of ESRD in some patients. We propose that prospective studies be undertaken to determine whether this is the case.

Age Factors↗
PubMed1986

Retinoids induce U937 cells to express macrophage phenotype.

The effects of two retinoids, all-trans-retinoic acid (t-RA) and 13-cis-retinoic acid (c-RA) were studied in a model of osteoclast precursors. The model employs the U937 cell line induced to differentiate when incubated with 1 alpha,25-dihydroxyvitamin D3 and conditioned medium from stimulated human lymphocytes. t-RA and c-RA (10(-8) to 10(-6) M) inhibited cellular growth rates and increased surface adherence. However, t-RA and c-RA both partially blocked the differentiation induced by 1,25(OH)2D3 and lymphokines. Thus, retinoids alone promoted the differentiation of U937 cells but partially blocked the differentiation induced by a vitamin D metabolite and lymphokines. These results suggest that vitamins A and D may exert antagonistic effects on the recruitment of osteoclast precursors.

Antigens, Surface↗