Biomedical subjects
Publications and source records attributed to F W Peter.
The microenvironment of healing human skin wounds is continuously monitored by a cutaneous chamber model. In recent studies in patients, baseline data for barrier function, temporal profiles of growth factors, and other mediators of healing were established. This model may be useful in clinical research of modulators of healing and wound pharmacology.
There is now a growing awareness of the central role of platelet function in microvascular thrombosis. Platelet aggregation studies remain one of the most useful ways of studying platelet function and response to different stimuli. This brief communication highlights some of the main variables that can affect platelet aggregation in rats and emphasizes the existence of important differences in these variables compared with human platelet aggregation.
Since the early seventies over 300 studies have used the cremaster muscle as a flap model, yet little has been reported on the upstream feeding vessels of this muscle. The purpose of this study was to investigate the anatomy of the cranial feeding vessels of the left and right cremaster muscle in Sprague-Dawley rats. An additional aim was to compare these results with the anatomy of the feeding vessels of the cremaster muscle in another strain (Wistar). To permit identification of the cranial feeding vessels, the pedicle was dissected very carefully and thereafter perfused with green dye, which was administered through a cannula placed in the distal femoral artery. In Sprague-Dawley rats it was found that the cremaster muscle in only 30% of the animals received its total blood supply through the superior external pudendal artery. In Wistar rats the same was true in less than 45%. The cremaster muscle of the rest of the animals appeared to receive its blood either in part or in total from the hypogastric trunk. We suggest that the name pudic-epigastric trunk be abandoned.
Federal guidelines requires written informed consent for each operation. The patient has to be informed about important facts concerning the treatment. The specific risks always have to be mentioned in detail. If the patient is not able to agree expressly because of his serious injury, he can be treated without express consent. The extent of the preoperative information depends on the indication: the more urgent the treatment, the less detailed the amount of information and vice versa.
Ultrasonography of the hand is rarely applied, so normal and pathological findings remain unfamiliar to daily routine. Although all anatomical structures can be identified by this method, the median and ulnar nerves may be difficult to demonstrate, so they are often identified only by exclusion. Ultrasound is a non-invasive method and very helpful in diagnosing pathological changes, such as ganglions and other tumors, synovialitis, carpal tunnel syndrome, tendon injuries, and anatomical malformations.
The treatment rationale of a burn victim (35% TBSA) who was child of Jehova's witnesses is described. Following a combined approach including erythropoetin and blood saving surgical techniques we were able to excise and graft the burn areas without blood transfusion. An extremely low hemoglobin of 3.4 g/dl was tolerated postoperatively and showed an increase to 10.9 g/dl 25 days later when the child was dismissed from the burn unit in stable condition. Possibilities to minimize blood loss and to avoid blood transfusions are discussed.
Scalp defects in combination with exposure of the skull require early debridements and immediate soft tissue coverage by local flaps or free tissue transfer. Tactical and technical treatment rationale options are discussed, which are necessary to achieve patient specific reconstructive procedures.
The most frequent reason for relaparotomy is peritonitis, followed by mechanical ileus and secondary hemorrhage. The most common cause of postoperative peritonitis is insufficient anastomosis. The relative proportion of cases of localized peritonitis is increasing. Diffuse peritonitis is still treated by operation, according to instructions of Kirschner 1926, whereas localized peritonitis is more and more treated by percutaneous puncture. The prognosis of postoperative peritonitis is poor.
61 patients with suggested pancreatic disease were examined by Hypotonic Duodenography (HD) and Computed Tomography (CT). After all examinations had been carried out, 45 patients were found to have an abnormal pancreas, and 16 patients had a normal pancreas. HD had a sensitivity of 60%, and a specificity of 94%, whereas CT had a sensitivity of 78% and a specificity of 100%. - HD is more sensitive than CT in detecting lesions originating from pancreatico-duodenal structures. In patients with uncertain clinical symptoms of the upper gastrointestinal tract HD is still a valuable basic examination. Only in patients with strongly suspected pancreatic carcinoma radiologic examination should start with CT because CT is more sensitive in detecting a pancreatic lesion and is helpful in assessing its extension and defining its etiology.