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Biomedical subjects

F W Vreeling

Publications and source records attributed to F W Vreeling.

13 recordsLinked to original sources
PubMed2006

Prevalence of primitive reflexes and the relationship with cognitive change in healthy adults: a report from the Maastricht Aging Study.

OBJECTIVES: Primitive reflexes (PR) generally disappear early in life but may reappear later, in which case they are often associated with chronic neurological conditions, such as dementia or Parkinson's disease. Studies have shown that the presence of PRs may be indicative of both the severity and rate of progression of these diseases and may be the result of disinhibition of cortical networks. The association between PRs and cognitive function in usual ageing is unclear. We investigated whether the occurrence, amplitude, and persistence of four nociceptive (glabbelar tap, palmomental, pollicomental, and snout reflexes), three prehensile reflexes (suck, palmar grasp, and rooting), and two other reflexes (mouth open finger-spread and nuchocephalic reflexes) were related to performance in specific cognitive domains in normal ageing individuals. METHODS: Four-hundred and seventy normal aging participants (25-82 years) in the Maastricht Aging Study (MAAS), were included in the study. They were neurologically and cognitively screened at baseline and were retested after 3 (only individuals aged 50 years and older at baseline) and 6 years. RESULTS: The prevalence of most PRs increased with age: 47% of men aged 25-45 years had at least one PR, compared with 73% of men aged 65-85 year (p = 0.002). In women these percentages were 51 and 75, respectively (p=0.008). The prevalence, amplitude, and persistence of PRs were unrelated to cognition at baseline or at the 3- or 6-year follow-up. CONCLUSIONS: The prevalence of particularly nociceptive reflexes rises substantially with increasing age in normal individuals. However, the presence of PRs cannot be considered to be a marker of cognitive decline in normal aging individuals.

Adult↗
PubMed2000

[Successful treatment of depression in a Parkinson disease patient with bupropion].

A 70-year-old female patient with Parkinson's disease was admitted to hospital with a medication-resistant depression. Electroconvulsion therapy was considered indicated, but it was decided to try treatment with bupropion chloride first. This resulted in a quick and complete remission of depressive symptoms, without any negative effects on motor symptoms. Bupropion has a unique mechanism of action: inhibition of the presynaptic reuptake of dopamine in addition to noradrenergic activity. Furthermore, it lacks the negative adverse effects on the extrapiramidal symptoms, that may be a problem if other antidepressants are used in the treatment. Bupropion is useful as an antidepressant in specific patient groups, notably patients with Parkinson's disease.

Aged↗
PubMed1995

Primitive reflexes in Alzheimer's disease and vascular dementia.

Data on the prevalence and clinical value of primitive reflexes (PRs) in dementia are controversial, mainly due to a lack of standardization of the methods by which these signs are elicited and scored. A standardized protocol was used to investigate eight PRs in 20 patients with Alzheimer's disease (AD), 20 patients with vascular dementia (VD), and 20 control subjects for each group. Both patient groups showed considerably more PRs than the control groups. The prevalence of PRs was related to the severity of dementia. No single reflex or combination of PR pathognomonic for dementia could be distinguished. The PR profile of AD and VD patients were similar.

Aged↗
PubMed1993

[Psychiatric disorders in patients of a memory outpatient clinic].

OBJECTIVE: To determine whether psychiatric conditions other than depression are relevant in elder patients with memory disturbances. METHODS: 430 consecutive outpatients (242 males, 188 females; mean age 61.7 years) who visited the Maastricht Memory Clinic were examined, according to a standardised diagnostic procedure, including somatic, neurological, psychiatric and neuropsychological examination. Psychiatric disorders were diagnosed according to DSM-III(-R) criteria. RESULTS: Of 152 patients with dementia, 34 had a secondary depressive syndrome, 19 another secondary psychiatric disorder. Of the 37 patients with a psycho-organic disorder other than dementia, 16 had an organic mood disorder. Of the other 241 patients, 152 had 159 primary psychiatric diagnoses: mood disorders in 100 cases and other psychiatric disorders in 59 cases, especially adjustment disorders, anxiety disorders and personality disorders. Together, only 60% percent of all primary or secondary psychiatric disorders were mood disorders. Various ways in which organic substrate, cognitive problems and psychopathology can be interrelated are discussed. CONCLUSION: Although affective disorders were the most frequent psychiatric disorders, several other psychiatric conditions were related to memory disturbances as well. Psychiatric assessment in patients with memory complaints should not be restricted to the diagnosis of depressive symptoms.

Adolescent↗
PubMed1993

Primitive reflexes in healthy, adult volunteers and neurological patients: methodological issues.

A study was made to determine whether two experienced clinicians elicited and scored primitive reflexes (PR) differently and whether reliability could be improved by standardization. Three studies were carried out, using a protocol for the examination of 14 PR. In the first study with 31 healthy young subjects, two investigators found virtually no difference in the routine neurological examination. However, the interobserver agreement was very poor, indicating the need for a further improvement of the PR protocol. In the second study, 30 neurological patients were examined with an improved, more explicit and standardized protocol, in which the amplitude and the persistence of the reflex were scored separately. Interobserver agreement improved considerably, and was high for amplitude as well as persistence. In the third study, 36 neurological patients were examined twice by one investigator within 2 weeks. Good to excellent intraobserver agreement was found. No pathognomonic or strictly localizing reflex could be distinguished.

Adolescent↗
PubMed1993

Primitive reflexes in Parkinson's disease.

A standardised protocol for the examination of 15 primitive reflexes in which the amplitude and the persistence were scored separately, was applied to 25 patients with Parkinson's disease and an equal number of healthy matched control subjects. Most reflexes were found considerably more often in the patients than in the control subjects, especially the snout, the glabellar tap, and its variant, the nasopalpebral reflex. Only the mouth open finger spread reflex was present more often in the control subjects. For all reflexes except this last, the scores for amplitude and persistence of the reflexes for the control group never exceeded the scores for the patient group. Reflexes persisted more often in the patients than in the control subjects. Parkinsonism alone can explain a large number of primitive reflexes, irrespective of the severity or duration of the disease. In contrast, the number of reflexes was related more closely to cognitive scales. It is concluded that such reflexes may be helpful in diagnosing Parkinson's disease. In addition, a standardised protocol for eliciting and scoring is essential for the study of these reflexes in parkinsonism and other neuropsychiatric conditions.

Adult↗
PubMed1993

Diagnosing dementia: a comparison between a monodisciplinary and a multidisciplinary approach.

Discrepancies were examined in diagnostic outcome between a monodisciplinary approach and a multidisciplinary, criteria-based approach in patients referred to a university memory clinic. Of 278 patients not fulfilling dementia criteria, 19 had been previously diagnosed as demented (specificity: 0.93). In 60 of 152 demented patients, dementia had not been diagnosed before (sensitivity: 0.61). Underreporting was frequent for mildly demented patients and for patients with coexisting depressive symptoms. In patients referred by psychiatrists, sensitivity rates for dementia and Alzheimer's disease were low; in patients referred by neurologists, depression often went unreported. Results underscore the need for more frequent use of integrated multidisciplinary services for cognitively disturbed patients.

Aged↗
PubMed1991

Rigorous health screening reduces age effect on memory scanning task.

Eighty subjects participated in a study with five age groups (20, 30, 40, 50, and 60 years). Forty subjects showed evidence of factors related to brain dysfunction (risk factors). Their performance on a Sternberg-type memory scanning task was assessed. Age-related slowing of virtually all aspects of the memory scanning process was observed in the healthy group. However, the effect of the presence of risk factors was larger than that of biological age. The results of the present study make a reasonable case for the view that many age effects reported in the literature can be largely explained by suboptimal brain functioning, i.e., by other factors than aging per se.

Adult↗
PubMed1985

Successful treatment of tuberculous brain abscess.

A case of tuberculous brain abscess occurred in spite of 4 months' treatment of pulmonary tuberculosis with a triple drug anti-tuberculous regimen. Surgical removal and further chemotherapy were successful.

Brain Abscess↗
PubMedDate not supplied

Stroop interference: aging effects assessed with the Stroop Color-Word Test.

A large, cross-sectional aging investigation of performance on the Stroop Color-Word Test (SCWT) was carried out. Subjects were 247 volunteers, ages 20-80 in seven age levels. Although all subjects thought themselves to be normal and healthy, a post hoc division could be made on the basis of biological life events (BLE). BLE are mild biological or environmental factors, such as repeated experiences of general anesthesia, that can hamper optimal brain functioning. Apart from the anticipated age effects, performance was poorer in subjects who had experienced one or more BLE: The slowing due to BLE was comparable to the effect of age, especially on the task involving language interference in color-naming. Education had a significant effect on performance: More highly educated subjects performed better than less educated subjects. No sex differences were observed. These findings replicate observations made with other tests in parallel studies. They are also in line with several other studies reporting interactions between the effects of aging and physical fitness. This study questions some of the validity of cognitive aging research, as our data suggest that screening for BLE as age-extrinsic factors in nondiseased subjects can reduce many of the performance deficits usually ascribed to aging per se.

Adult↗