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Biomedical subjects

F Weise

Publications and source records attributed to F Weise.

36 records · Page 2Linked to original sources
PubMed1993

[Pressure variability in the cold-pressure response test].

The effect of the immersion of the hand in ice water for 5 minutes on the short-term variability of blood pressure (BP) and heart rate (HR) was evaluated in 10 normal subjects. Indirect finger BP was measured by a non-invasive device (Finapres). Analogue-to-digital conversion of the BP was used to determine systolic, diastolic BP and HR every 0.5 second. The equidistant sampling allowed a direct spectral analysis using a fast Fourier transform algorithm on 256 point time series of a stationary period. BP was increased (+28 mmHg for systolic BP and +13 mmHg for diastolic BP) and an increased overall variability of BP and HR was observed during the cold pressor test. The increased areas under the curve of the systolic, diastolic BP and HR spectra were documented with the selective analysis of the two main components of the spectra: the increase in the oscillations of BP and HR during the test predominated in the 70-140 mHz region (+30% for systolic BP, +24% for DBP and +21% for HR), corresponding to Mayer waves. The high-frequency (respiratory) component of BP and HR variability was unchanged. The significant increase in the 10 second period oscillations of BP could reflect the cold-induced sympathetic vasoconstriction.

Adaptation, Physiological↗
PubMed1992

Effects of plasmapheresis on short-term variability of blood pressure in healthy donors.

The acute effect of mild central hypovolaemia induced by plasmapheresis on the short-term variability of blood pressure and heart rate was evaluated in ten healthy donors. Indirect finger blood pressure was measured by a non-invasive device (Finapres). Analogue-to-digital conversion of the blood pressure was used to determine systolic, diastolic and mean blood pressure and heart rate every second. The equidistant sampling allowed a direct spectral analysis using a fast Fourier transform algorithm. Blood pressure and heart rate were maintained while an increased overall variability of blood pressure was observed after plasmapheresis. The increased total area under the curve of the systolic and diastolic blood pressure spectra was documented with the selective analysis of the three main components of the spectra: the increase in the oscillations of blood pressure following plasmapheresis predominated in the 66-129 mHz region, corresponding to Mayer waves. The spectral profile of HR was unaffected by plasmapheresis. The significant increase in the 10-s period oscillations of blood pressure after the mild central hypovolaemia could result from the unloading of cardiopulmonary (and arterial) baroreceptors which in turn could buffer the arterial pressure through sympathetic activation, detected on the systolic and diastolic pressure spectra in the low-frequency range.

Adult↗
PubMed1991

Age-related changes of heart rate power spectra in a diabetic man during orthostasis.

We used spectral analysis of heart rate variability during orthostatic load in diabetic patients in order to provide quantitative information about first, the alterations of vagal and beta-adrenergic nervous system influence on the heart and secondly, the relation of spectral components of heart rate variability to age. The respiration-related power, and indirect estimate of vagal cardiac control, was significantly reduced in diabetics as compared with controls in both the supine (diabetics: 0.39 (0.18-1.15) l/min2 [median and 25-75% percentiles], controls: 1.52 (0.54-3.84) l/min2, 2P less than 0.01) and the standing (diabetics: 0.27 (0.12-0.84) l/min2, controls: 2.22 (0.67-5.14) l/min2, 2P less than 0.0001) body posture. The difference between supine and standing values of mid-frequency power (delta MF power) that represents beta-adrenergically mediated heart rate variability was significantly smaller in diabetics (delta MF: 0.79 (0.18-3.84) l/min2) than in controls (delta MF: 8.07 (4.35-17.99) l/min2) (2P less than 0.0001). Power of almost all frequency components declined exponentially with age in both positions and groups studied. The decline in power of heart rate variability was more pronounced in controls than in diabetics for either posture. An age-associated significant decrease in delta MF was found in controls (Y = 33.16-0.60X, P less than 0.05, r = -0.49) as compared to diabetics (Y = 8.70-0.16X, P greater than 0.05, r = -0.24). Our results suggest a decreased vagal and sympathetic nervous system input into the heart in diabetics. The premature loosened coupling between heart rate spectral power and age suggests that diabetes mellitus accelerates the aging process. Computerized spectral analysis of heart rate variability seems to be a very sensitive tool to evaluate the influence of the autonomic nervous system on the heart.

Adult↗
PubMed1990

Heart rate variability in diabetic patients during orthostatic load--a spectral analytic approach.

Spectral analysis of heart rate variability (HRV) was used to assess the autonomic nervous control of cardiac function during orthostatic load in insulin-dependent diabetic patients and healthy subjects. The diabetic patients were divided into three groups: diabetics without neuropathy (group 1), diabetics with peripheral neuropathy (group 2), and diabetics with peripheral and autonomic neuropathy (group 3). Resting mid-frequency (MF, 0.05-0.15 Hz) and respiration-related (RF, power around respiration rate) HRV were significantly lower in group 2 and 3 diabetics than in controls, indicating a reduced parasympathetic nervous system influence on the heart. Standing MF and RF spectral power data were significantly lower in all diabetic groups than in controls, suggesting marked alterations in the autonomic cardiovascular control during a mild physical load not only in symptomatic diabetics but also in patients with no signs and symptoms of neuropathy. The difference between supine and standing MF power, an estimate of beta-adrenergic influence on the heart, was significantly lower in all diabetic subject groups studied than in controls. This suggests a reduced sympathetic nervous system influence on the heart in diabetic patients. Our data suggest that computerized spectral analysis of HRV during orthostatic load seems to be a very sensitive method of evaluating of the autonomic nervous systems influence on the heart in patients suffering from diabetes mellitus.

Adult↗
PubMed1990

A non-invasive approach to cardiac autonomic neuropathy in patients with diabetes mellitus.

The purpose of this study was to obtain information regarding the participation of the sympathetic nervous system in cardiac autonomic neuropathy in patients suffering from diabetes mellitus employing spectral analysis of heart rate variability in the supine and standing posture. Ten insulin-dependent diabetic patients (29 +/- 2 years) with a short to moderately long duration of diabetes (11 +/- 1 years) and cardiac vagal neuropathy based on measurements of respiratory sinus arrhythmia were compared to 10 healthy volunteers (27 +/- 1 years) before and after the administration of atropine and atropine plus propranolol. In diabetic patients the reactivity in total power (delta TP) from supine to upright position was significantly lower compared to control subjects before and after atropine. There was no significant difference in delta TP between diabetics and controls after atropine plus propranolol. The magnitude of TP increase is essentially due to the increase of blood pressure related heart rate fluctuations (delta MF) from lying to standing and dependent on beta-adrenergical efferent activity to the heart. In diabetic patients as well as in normal subjects under the influence of atropine plus propranolol the delta MF power was significantly lower compared to the unmedicated control and atropine group. There was no significant difference between diabetics and controls after combined autonomic blockade. It was concluded that delta MF heart rate spectral power could serve as an indirect, non-invasive, quantitative and sensitive marker of early cardiac sympathetic damage.

Adult↗
PubMed1989

Effect of low-dose atropine on heart rate fluctuations during orthostatic load: a spectral analysis.

Spectral analysis was utilized in order to determine the influence of low (0.7 microgram/kg)-dose atropine sulfate injections on the isolated spectral power components of heart rate fluctuations in contrast to moderate (0.02 mg/dose)-dose atropine and unmedicated states in human subjects during orthostatic load. Low-dose atropine decreased mean heart rate and increased respiration-related spectral power compared with controls in both the supine and standing posture. In supine subjects total power (0.01-0.5 Hz) was unchanged compared with controls due to a decreasing trend of low-frequency (0.01-0.05 Hz) and mid-frequency (0.05-0.15 Hz) heart rate spectral power. Standing upright, there was a distinct increase in total power with significantly higher values than in the controls resulting from an enormous activation of mid-frequency heart rate fluctuations. The peak frequency of the mid-frequency component was increased with a strong tendency compared with controls. Moderate-dose atropine increased mean heart rate and decreased total power, mid-frequency and respiration-related heart rate spectral power and peak frequency compared with controls in both positions. Our results suggest that low-dose atropine affects the interaction between sympathetic and parasympathetic limbs in the autonomic control of cardiac function in a complex manner producing a differentiated pattern of heart rate fluctuations dependent on the body posture. We suggest that low-dose atropine augments and moderate-dose atropine attenuates the vagal cardiac efferent activity in each position.

Adult↗
PubMed1989

Effects of modified respiratory rhythm on heart rate variability during active orthostatic load.

The experiments were carried out to study the influence (a) of 3 different respiratory frequencies (0.12, 0.20 and 0.35 Hz) on heart rate power spectra during orthostatic load with special reference to the peak frequency of mid-frequency heart rate fluctuations, and (b) of variation in respiratory depth on this peak frequency in supine position. The peak frequency of mid-frequency heart rate fluctuations was shifted to lower frequency values in response to orthostasis despite the constant respiratory frequency for either posture. No differences in peak frequency were observed between respiratory frequencies of 0.20 and 0.35 Hz in both supine and standing position and between the two extreme patterns of respiratory depth. We suggest that the shift of the peak frequency of mid-frequency heart rate fluctuations to the lower end of the heart rate power spectrum during orthostasis represents an original effect independent of depth and frequency of respiration.

Adult↗
PubMed1987

Contributions of sympathetic and vagal mechanisms to the genesis of heart rate fluctuations during orthostatic load: a spectral analysis.

Spectral analysis was utilized in order to determine the influence of postural change on heart rate fluctuations and respiratory frequencies and to evaluate the frequency-specific contributions of both vagal and beta-adrenergic mechanisms to the genesis of the heart rate fluctuations during change in posture. In unmedicated subjects the total power (0.01-0.5 Hz) of heart rate fluctuations and the relative power at the mid-frequency band (0.05-0.15 Hz) were significantly increased in response to postural change, while the relative power of high-frequency fluctuations (0.15-0.5 Hz) was significantly depressed. Low-frequency fluctuations (0.01-0.05 Hz) were unchanged. The respiratory frequency was non-significantly slowed. The coherence between heart rate and respiration showed a significant reduction during orthostatic load. The heart rate fluctuations above 0.05 Hz were abolished by vagal blockade, during supine rest, while beta-adrenergic blockade reduced fluctuations at the mid-frequency band. Combined blockade caused a depression of heart rate fluctuations over the entire frequency range. On standing, vagal blockade or autonomic double blockade caused a decrease in heart rate fluctuations at each frequency band. After beta-adrenergic blockade alone, mid-frequency and high-frequency fluctuations were significantly reduced. The coherence between heart rate and respiration was nearly abolished under vagal blockade in each body posture. We conclude that the increased sympathetic outflow during orthostatic load is reflected by a marked increase in heart rate spectral power densities in the mid-frequency range.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

Acute alcohol ingestion reduces heart rate variability.

Blood pressure, heart rate and heart rate variability (HRV) prior and during acute ethanol intoxication (0.7 g/kg) were studied in 8 healthy volunteers. Blood pressure and heart rate remained unaltered during intoxication. While HRV was significantly reduced immediately after ingestion (2P = 0.01). It is speculated that the reduction of HRV after heavy ethanol consumption contributes to the genesis of cardiac arrhythmias in chronic alcoholics with or without clinical evidence of heart disease.

Adult↗
PubMed1986

Heart rate variability in chronic alcoholics: a follow-up study.

Heart rate variability (HRV) was studied in 11 chronic alcoholic subjects, 1-30 days after the beginning of abstinence and again 5, 12 and 24 weeks later. Two patients could be re-examined after 19 and 22 months, respectively. In the follow-up study, the total patient group showed a statistically significant increase in HRV with prolonged abstinence of at least 6 months. No recovery of efferent vagal function was found in 4 patients. It is suggested that the vagal neuropathy may improve in chronic alcoholics, but perhaps only in patients with a short to moderately long duration of drinking history or a functional rather than an organic vagal damage.

Adult↗
PubMed1985

[Course of heart beat variability following acute alcohol intake].

Blood pressure, heart rate and mean momentary arrhythmia were measured in 16 healthy test persons before and after acute alcohol ingestion. While the blood pressure remained unchanged, heart rate and mean momentary arrhythmia showed significant differences in comparison to the initial value, in which case the clearer change of the mean momentary arrhythmia in relation to the heart rate emphasizes the sensitivity of the parameter. The results are discussed as a sequel of the increase of sympathetic activity of alcohol/acetaldehyde.

Adult↗
PubMed1985

[Autonomic alcoholic polyneuropathy].

Measurement of heart rate variability was performed in a group of 106 healthy volunteers and 31 alcoholics. The mean momentary arrhythmia of normal individuals shows an exponential decrease with growing age. In 5 of 31 alcoholics a cardiac autonomic neuropathy was found with this parameter. The withdrawing alcoholics had a significant increase of heart rate and decrease of heart rate variability compared to later measurements, what is in agreement with the concept of hyperexcitability in early withdrawal.

Adolescent↗
PubMed1985

Heart rate variability of chronic alcoholics in withdrawal and abstinence.

Measurement of heart rate variability was performed in 106 healthy volunteers and 31 alcoholics. The mean momentary arrhythmia (MMA) of normal individuals showed an exponential decrease with increasing age. Cardiac autonomic neuropathy was found in 5 of 31 alcoholics. In agreement with the concept of hyperexcitability the withdrawing alcoholics had a significant increase in heart rate and decrease in MMA compared to later measurements. The result suggests that the diagnosis of autonomic alcoholic neuropathy may be reliable only after at least a one week period of abstinence from alcohol.

Adolescent↗
PubMedDate not supplied

Heart rate fluctuations in diabetic patients with cardiac vagal dysfunction: a spectral analysis.

The autonomic nervous control of cardiac function during active orthostatic load has been studied by measuring the power spectrum of heart rate fluctuations in 16 insulin-dependent diabetic patients and 14 age-matched control subjects. The patients were subdivided into two groups: 8 with normal respiratory sinus dysrhythmia (RSA+) and 8 with reduced respiratory sinus dysrhythmia (RSA-). In RSA- patients the total power (0.01-0.50 Hz) was significantly reduced compared with control subjects (4.7 versus 15.5 min-2, 2p less than 0.05) and the pattern of heart rate fluctuations was characterized by a relative increase in the low-frequency component (0.01-0.05 Hz) as compared with RSA+ patients and control subjects (45% versus 24% and 27%, both 2p less than 0.01). There was also a significant reduction in the high-frequency component (0.15-0.50 Hz) as compared with RSA+ patients and control subjects (17% versus 36% and 33%, both 2p less than 0.05). During standing, a significant increase in total power was found only in control subjects (2p less than 0.01) and the difference between control subjects, and RSA+ and RSA- patients reached significance (32.2 versus 15.1 and 12.7 min-2, 2p less than 0.02 and 2p less than 0.01). The pattern of heart rate fluctuations in RSA- patients showed no significant change on standing. These results suggest that the reduced overall heart rate variability in diabetic patients with cardiac autonomic neuropathy is associated with a typical heart rate fluctuation pattern.

Adult↗