PubMed Health⌕ Search

Biomedical subjects

F Zaunbauer

Publications and source records attributed to F Zaunbauer.

15 recordsLinked to original sources
PubMed1979

Vertebra plana Calvé.

The differential diagnostic problems of a case of vertebra plana Calvé having a rare location in the cervical spine are discussed. The various theories of aetiology and pathogenesis are considered briefly. The differentiation from inflammatory and tumourous diseases of the vertebral column is of great importance for therapeutic reasons. Skeletal scintigraphy was used for the first time for differential diagnosis in the case presented.

Cervical Vertebrae↗
PubMed1978

Further clinical experiences of a phase I study with the hypoxic cell radiosensitizer misonidazole.

Since April 1976 we have performed clinical investigations with multiple doses of the hypoxic cell radiosensitizer misonidazole in 21 patients. A significant side effect of the drug was the development of peripheral sensory neuropathies in 13 patients (8 mild, 5 severe) and of a transient acute organic psychosyndrome in 2 of the 5 patients with a severe polyneuropathy. The severity of the polyneuropathies is related to the total dose of misonidazole and the overall time of drug administration. Treatment schedules designed to obtain the desired sensitizing effect without neurological side effects are under investigation.

Adolescent↗
PubMed1978

[Psychic disturbances in patients with cervical intervertebral disk changes and cervical osteochondrosis].

The paper is concerned with the investigation of 51 patients with alterations of cervical intervertebral disks and cervical osteochondrosis who have undergone surgical intervention. The examination included a psychiatric interview as well as the application of paper pencil tests. Seventeen patients indicated symptoms of an endogenous depression. The group of depressed patients offered a significantly slow onset of cervical symptoms and, in the period after the operation, complained more often than the group without depressive symptoms. The psychological test revealed an increased tendency of inhibition and anxiety of the depressed group. Lastly, methodical problems are discussed concerning the evaluation of the lapse of psychic conduction as tension over a long period.

Adult↗
PubMed1977

[Surgical indications in lesions of the brachial plexus].

The development of microsurgery and the improved technique of nerve grafting brought new hope in cases of brachial plexus injury. Especially the Tinnel-Hofmann sign is a very helpful parameter in preoperative examination. Cases without any regeneration or no advancement should be operated between 3 and 6 months after the injury. Neurolysis or nerve grafting should be performed. In cases of avulsion of the roots a reneurotisation by nerve transfer is the technique of choice. The intercostal nerves are connected with important parts of the brachial plexus. Also in late cases (after 6 months) an epineurectomy and neurolysis may help to encourage further regeneration. Useful recovery could be achieved in a fairly high number of patients by restoration of continuity by nerve grafts or neurolysis. The functional results can further be improved by exploiting all available reconstructive techniques.

Angiography↗
PubMed1977

Initial clinical experience with the radiosensitizing nitroimidazole Ro 07-0582.

The 2-nitroimidazole derivate Ro 07-0582 is known from experimental studies to be a very efficient radiosensitizer of hypoxic cells. Experiences with its clinical use are very limited so far. This study reports the side effects observed in the use of this drug in 12 patients. Nine of these patients were suffering from brain tumors, 3 from extracerebral tumors. In 8 of our 12 patients a sensoric polyneuropathy occurred which was strongly related to the total dose of the drug administered. Polyneuropathy was observed on the average after a total dose of 26 grams, but was already noticed at doses as low as 22 grams. It showed a good tendency for remission after termination of the drug treatment and was reversible in all patients within 4 weeks. In one patient with a brain tumor a severe organic psychosyndrome occurred which is possibly related to the drug. This side effect was also reversible. In this small group of patients the critical dose limit seems to be 29 grams. This dose can be divided into 6 fractions of 60-80 mg/kg. Up to the present knowledge this single dose is likely to give an enhancement ratio of 1,5, which would be extremly valuable for the treatment of hypoxic tumor cells.

Adolescent↗
PubMed1976

[Cytostatic therapy in a patient with histologically verified, but not irradiatied, brain stem glioma (author's transl)].

A boy, aged 8 1/2 years, was operated becuase of a brainstem tumor (polymorph mixed glioma) more than 4 years ago. Because of its dimension and location in the medulla oblongata the tumor was resected only partially. Radiotherapy was refused at that time. A combined cytostatic therapy proved to be successful. The marked neurological symptoms diminished considerably during treatment. The patient (with minor neurological symptoms) has been living a normal and active life for the last 4 years.

Brain Neoplasms↗