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F Zucchetti

Publications and source records attributed to F Zucchetti.

At least 19 recordsLinked to original sources
PubMed2002

Galectin-3, a marker of well-differentiated thyroid carcinoma, is expressed in thyroid nodules with cytological atypia.

AIMS: The distribution of galectin-3, a widely recognized marker of well-differentiated thyroid carcinoma, was investigated in 95 thyroid lesions including nodules with foci of cytoarchitectural atypia. METHODS AND RESULTS: Twenty-eight papillary carcinomas, five follicular carcinomas, one Hurthle cell carcinoma, three poorly differentiated carcinomas, one anaplastic carcinoma, 25 nodular hyperplasias and 27 follicular adenomas, including nodules with atypical features, three neoplasms of undetermined malignant potential and two thyroiditis cases were examined. By immunohistochemistry, galectin-3 was consistently found in carcinomas; otherwise benign nodules exhibited galectin-3-positive clusters of cells with poorly developed features of differentiated carcinoma (mainly of papillary type) such as nuclear chromatin clearing, nuclear clefting, pseudoinclusions, which, in each case, were not histologically sufficient to warrant a definitive diagnosis of malignancy. In other nodules galectin-3 staining was negative. The latter were either clearly benign or showed constantly a minor degree of chromatin clearing and of other atypical features when compared with galectin-3-positive cases. CONCLUSIONS: Galectin-3, a reliable marker of differentiated thyroid carcinoma as confirmed in our series of malignant neoplasms, appears expressed in nodules with an overall benign appearance but with focal areas suspicious for malignancy. The significance of such findings needs to be further investigated.

Antigens, Differentiation↗
PubMed2000

Papillary carcinoma in amyloid goitre.

Amyloid goitre is a rare lesion characterized by a diffuse and bilateral enlargement of the thyroid gland due to amyloid deposition. It is uncommon that a massive and widespread amount of adipose tissue deposition is found within these lesions and only in exceptional cases a differentiated carcinoma can develop. We describe the third example of thyroid carcinoma, arising in a 74-year old female who had also massive adipose thyroidal metaplasia, within amyloid goitre. The Congo red stain confirmed the diagnosis of amyloid goitre. Immunohistochemistry showed reactivity with MoAb against amyloid fibril protein A. The patient suffered from renal failure of undetermined aetiology for three years, but neither systemic amyloidosis nor risk factors for its development were found. It is important to correctly diagnose amyloid goitre both to rule out the presence of a differentiated thyroidal carcinoma and to search for amyloid infiltration in other organs in view of an early appropriate therapy.

Aged↗
PubMed1991

[Regional hemodynamic evaluation of heterotopic liver transplantation by the determination of the hepatic artery resistance index].

Hepatic artery resistance index (I.R.) was evaluated in six pigs through Doppler scan after progressive gauge reduction of the portal vein up to complete clamping. The I.R. values were (mean +/- S.D.): 0.48 +/- 0.01 in basal conditions; 0.37 +/- 0.03, and 0.33 +/- 0.01 with a reduction of 1/3 and 2/3 respectively; 0.27 +/- 0.02 after complete portal clamping. These data confirm the close relationship existing in the hepatic circulation between changes of the arterious resistence and those of the portal flow. The same animals, subsequently, underwent heterotopic liver transplantation in the right paracolic gutter. Immediately after surgery the I.R. values of the transplanted hepatic artery were recorded without clamping (basal portal flow 0.52 +/- 0.02) and after clamping of the transplanted portal vein (0.33 +/- 0.03), while maintaining clamped the recipient portal vein at the hilus. These values were comparable to those obtained in the recipient hepatic artery. These data suggest that, in spite of parenchymal damages secondary to surgical procedure and of the haemodynamically unfavorable site in which the organ is transplanted, heterotopic liver transplantation does not produce significant changes in hepatic arterious resistance.

Animals↗
PubMed1983

[Mechanical sutures in surgery of cancer of the rectum (a personal contribution)].

The EEA Stapler is widely employed in the rectal cancer surgery, particularly allowing a more frequent sphincteric preservation after low anterior resection. The authors rather employ the manual suture whenever possible and report their own experience on EEA Stapler employment in the surgical management of rectal cancer located 12 to 6 cm. from the anal verge. They emphasize this technique pointing out the necessity of further investigations which may confirm the possibility of obtaining a curative complete surgical removal as well as by abdomino-perineal resection.

Aged↗
PubMed1980

[Technical aspects of transileal ureterocutaneostomy].

The performance of the ileal conduit (Bricker's operation) is a well and minutely known surgical procedure (choice of a particular ileal loop; uretero-ileal anastomosis; uretero-cutaneostomy); however we can still observe several and different details in the operative technique management. The Authors, on the basis of their own experience of 55 cases, and after a complete review of the literature, emphasize the technical controversies of ileal loop urinary diversion; moreover they analyze the technic changes previously pointed out be several Authors, to avoid surgical complications. They conclude that the ileal conduit urinary diversion shall have less complication if: 1) the ileal loop is a short one, but with a very good blood supply; 2) antireflex techniques are not used; 3) Brooke's technique is used in performing uretero-cutaneostomy.

Humans↗
PubMed1977

[The cervical approach in surgery of the thymus for myasthenia. Comparison with the trans-sternal route. Considerations on 75 operated patients].

The role played by the surgical route on the immediate post-operative course has been studied on the basis of personal experience of thymectomy for myasthenia gravis (75 operated cases). Time of respiratory assistance, pleuropulmonary complications, operative mortality and recourse to trachetomy were evaluted in two homogenous groups of patients thymectomized cervically (group I: 36 cases) or trans-sternally (group II: 39 cases). It is was found that the average duration of respiratory assistance was significatly less in the first than in the second group (it was often not necessary at all), pleuropulmonary complications were halved, tracheotomy was never indicated and operative mortality was nil. The cervical approach thus offers enormous functional advantages and devers a leading place in surgery of the thymus; it would appear to be contraindicated only in the presence of radiologically evident thymomas and at times in cases where tracheotomy has been performed previously.

Humans↗