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Biomedical subjects

F Zych

Publications and source records attributed to F Zych.

At least 19 recordsLinked to original sources
PubMed1998

[Assessment of selected hormonal parameters in patients with mastopathy in postmenopausal period].

There have been assessed selected hormonal parameters in patients with mastopathy in postmenopausal period. The hormonal evaluation showed significantly higher mean concentration of prolactin in blood serum of patients with mastopathy than in the blood serum of healthy women. There was not functional hyperprolactinaemia in the patients in postmenopausal period. In the examined patients in postmenopausal age, there was revealed significantly higher mean concentration of oestradiol in blood serum, in comparison with the healthy women. There was also found significantly lower mean concentration of follicle-stimulating and luteotrophic hormones, which is probably due to enhanced inhibition of gonadotrophic hormones secretion by prolactin and oestradiol. The results of the conducted hormonal examinations suggest that prolactin is an agent, which produces mastopatial changes in women. Furthermore, it seems that genesis of mastopathy in postmenopausal period may be connected not only with disprolactinaemia but also with persistent oestrogenic activity. It should be thus admitted that hormonal examinations (with particular consideration given to prolactin) are appropriate management in diagnosis and treatment of patients with mastopathy.

Estradiol↗
PubMed1998

[Mastopathy and simple goiter--mutual relationships].

UNLABELLED: There have been assessed physical and ultrasonographic examination in patients with mastopathy and concentration of prolactin, thyrotropin, thyroxine in blood serum of these patients. The examination was carried out in 65 patients with mastopathy (group M), at the age ranging from 18 to 53 years, and in 30 healthy women (group K), at the age from 18 to 55 years as a reference group. The group of the patients with mastopathy and the control group were divided into three subgroups (taking into account the age and function of ovaries). There were excluded from the examined group patients whose general health state, particularly endocrinological disease, and applied drugs might condition occurrence of pathological changes in mammary glands. Particular attention was paid to exclusion from examination of patients with both primary and secondary hyperprolactinemia. Non-toxic goitre was found in 80% patients with mastopathy, and the results of palpation examination of thyroid were confirmed by thyroid ultrasonographic examination. Non-toxic goitre was significantly more often in patients with mastopathy in comparison with healthy women, and there was found significantly higher thyroid volume in these patients. The hormonal evaluation showed first of all significantly higher mean concentration of prolactin in blood serum of the patients with mastopathy than in the blood serum of healthy women in comparison with both the whole examined group and subgroups. There were not significant differences between the mean concentration of thyrotropic hormone, triiodothyronine and thyroxine in blood serum in premenopausal patients with mastopathy and mean concentration of these hormones in healthy women. Only postmenopausal patients were characterized by significantly lower mean concentration of triiodothyronine in comparison with the healthy subgroup. CONCLUSIONS: 1. In patients with mastopathy, there often coexists enlargement of thyroid gland, and prolactin may be also considered as an agent which influences genesis of a goitre. 2. It should be thus admitted that hormonal examinations with particular consideration to prolactin and thyroid hormones are appropriate management in diagnosing and treatment of patients with mastopathy.

Adult↗
PubMed1998

[TSH receptor antibodies in the recurrent goiter after surgical treatment of Graves-Basedow disease].

The serious complication after surgical treatment is goitre renewai. Very important is therefore the correct diagnosis based also on laboratory investigation, enabling early detection of dysthyreosis. The aim of work was assessment of immunological states of thyroid gland of patients with goitre recurrence treated surgically because of Graves-Basedow, based on investigation of TSH receptor antibodies. The time from the surgery to the examination ranged from two to eleven years. The laboratory investigation contained determination of thyroxin, free thyroxin triiodothyronin, thyreotropin and antibodies directed against TSH receptor(TRAb). It has been found that average concentration of TRAb and frequency was significantly higher in recurrent goitre then in group without goitre renewal. The results of investigation indicates usefulness of determination of thyroid antibodies in diagnosis of recurrent goitre after surgical treatment of Graves-Basedow disease.

Adult↗
PubMed1997

[Some aspects of fibrocystic breast disease].

The fibro-cystic disease is very common disease. Hormonal factors: hyperestrogenemia, luteal deficiency, dysprolactinemia are inconstant. They are neither necessary nor sufficient to induce the cystic disease. The relations GCD (gross cystic disease) with breast cancer remain the fundamental problem. Although the cyst itself only exceptionally degenerates into cancer, the presence of macrocystic disease multiplies by 3 to 4 the risk of cancer. A lot of interesting examinations were performed on cyst fluids aspirated from patients to identify women with benign breast disease and particular risk for breast cancer. Electrolyte profiles showed, that cysts fluids may be divided into major subpopulations, which differ in terms of histological appearance of cyst lining epithelium and levels of other fluid constituents. At the present time, the biochemical measurements in cyst fluids aren't popular to identify women likely to develop breast cancer. We should use other diagnostic methods to examine these patients.

Adult↗
PubMed1997

[Biochemical and endocrinological analysis of breast cyst fluid].

The gross cystic disease (breast cyst < 3 mm in diameter) is common benign disease of the breast. The relations GCD with breast cancer remain the fundamental problem. Although the cysts itself only exceptionaly degenerates into cancer, the presents of macrocystic disease multiplies by 3 to 4 the risk of cancer. A lot of interesting examinations were performed on cyst fluids aspirated from patients to identify women with benign breast disease and particular risk for breast cancer. There are two groups of breast cysts: these lined by apocrine epithelium and those lined by flattened epithelium. It is generally accepted that measurement of intracystic [Na+]/[K+] is a simple way of differentiating between these two groups of cysts. Higher intracystic concentrations of same substances may provide an explanation for the higher risk of breast cancer, which has been observed in low electrolyte group. Breast cyst fluid samples were analyzed for a lot of hormones, proteins, specific growth factors, adhesion molecules, bile acids, tumor markers and their levels were compared with breast cancer risk. At the present time, the biochemical measurements in cyst fluids aren't popular to identify women likely to develop breast cancer. We should use other diagnostic methods to examine these patients.

Adult↗
PubMed1996

[Fibrocystic disease of breast and pituitary-thyroid axis function].

The aim this study was to report findings on the concentrations of mean triiodothyroxine (T3), thyroxin (T4), thyroid stimulating hormone (TSH) and prolactin (Prl) in patients with benign mastopathy and in control group. All of the examined subjects were clinically euthyroid. The mean T4 concentrations in women with mastopathy (78.25 +/- 15.27 ng/ml) were significantly lower than in control group 88.73 +/- 15.27). The mean TSH and PRL concentration in women with mastopathy were higher, but not significantly, than in control women. This results indicate, that benign mastopathy seems to be connected with thyroid functions.

Adult↗
PubMed1995

[Evaluation of thyroid anti-membrane and anti-thyroglobulin antibody determination in patients with thyroid cysts treated with external drainage under ultrasonographic control].

In patients (43 women and 12 men) external open drainage under ultrasonography control was performed. In 25 cases contents of serous nature, in 27 cases of colloid and in 3 cases of suppurative character were obtained. Anti-membrane thyroid antibodies (ATMA) and anti-thyroglobulin antibodies (Tg-Ab tire) were determined in the cyst contents as well as in the serum. The antibodies were present in the serum of 48% of the patients with serous cyst and in 52% with colloidal cysts. In serous cyst contents, ATMA and Tg-Ab antibodies were present in 52% of cases, while in the colloidal contents ATMA antibodies were found in 60% of patients and Tg-Ab antibodies in 68%. In 3 patients with cysts containing pus no antibodies were found. When antibodies were detected in the contents of serous and colloidal cysts their presence were also found in the serum. Among 55 cases with thyroid cysts, the antibodies were found in the serum of 47% of patients. The results indicate involvement of immunological factors the role of which has not been explained.

Adult↗
PubMed1994

The lack of melatonin rhythm in active acromegaly after radiotherapy.

The aim of the study was to evaluate the interrelation between the levels of growth hormone (GH), prolactin (PRL), somatomedin-C (Sm-C) and melatonin determined at 3 h intervals over a 24 h period (8.00, 11.00, 14.00, 17.00, 20.00, 23.00, 2.00 and 5.00) in 8 acromegalic patients after radiotherapy. The circadian rhythms and the interrelation between hormone and Sm-C levels were evaluated using Halberg's cosinor method and the correlation analysis, respectively. We observed a total abolition of melatonin rhythm with significantly lower nocturnal values in all patients which could be due to earlier radiotherapy.

Acromegaly↗
PubMed1994

[Zinc levels in semen of men from childless marriages].

Zinc concentration in human semen was studied on the material of 106 male patients aged 20-35, from childless marriages. Full microscopic examination was performed including number of spermatozoons, mobility, fluxing time, pH, morphological composition, number of leucocytes. Zinc level was measured using spectrophotometric analysis. Trial of relation estimation between zinc concentration and number of live spermatozoons and pH of the semen was taken out. Any significant differences between zinc concentration in the semen from normospermic and oligospermic males were found. There was proved, that semen pH increase was correlated to zinc concentration decrement in the semen fluid.

Adult↗
PubMed1993

[Ultrasonic diagnosis of cold thyroid nodules].

Ultrasonographic examination was carried out in 90 patients in whom single thyroid nodule was found by palpation and scintigraphic examination. In 67 of these patients (61%) the presence of a single nodule was confirmed by ultrasonography. In the remaining 23 (38%) multiple nodules were found within the gland. Ultrasonographic examination made possible the differentiation of solid lesions from the cystoid ones in 100%. Follicular adenomas appeared in ultrasonography as mixed-type nodules with the features of degeneration characterized by the presence of the areola (the so called "halo"). The Hurtle's adenomas appeared as mixed-type nodules, hypo-echogenic and devoid of areola. The observed neoplastic lesion (carcinoma follicular) was of a cystoid type. The appearance of cystoid lesions made possible the differentiation of simple cysts from those originating from tumor decomposition. Ultrasonography may then be helpful not only for distinguishing between cystoid-type and solid type lesions but also for classifying solid nodular structures as malignant or benign.

Adenoma↗
PubMed1993

[Usefulness of ultrasonic examination for evaluating the functional and morphologic state of the thyroid in patients with nontoxic and toxic parenchymal goiter].

Ultrasonographic examination of the thyroid was carried out in 150 patients of mean age 37 +/- 11 years, including 100 patients with nontoxic parenchymal goiter and 50 patients with toxic parenchymal goiter associated with the Graves' disease. Ultrasonograph Siemens Sonoline LM with 7.5 MHz head was used in the study. The study was aimed at the evaluation of functional and morphological state of the thyroid in patients with nontoxic and toxic parenchymal goiter. In the case of nontoxic goiter, heterogeneous (100%) and normoechogenic (100%) structure of the parenchyma was visualized by ultrasonography. In toxic parenchymal goiter (Graves' disease), on the other hand, hypoechogenic (92%) and marginally pseudo-cystoid structure of parenchyma was observed. In this group of patients, high values of thyroid hormones (100%) were associated with high level of thyroid antibodies (92%). It can be concluded that ultrasonography is an useful tool for evaluation of functional and morphological state of the thyroid in patients with nontoxic and toxic parenchymal goiter.

Adult↗
PubMed1992

[Zinc concentration in human semen of men from childless marriages].

Zinc concentration in human semen was studied on the material of 106 male patients aged 20-35, from childless marriages. Full microscopic examination was performed including number of spermatozoa mobility, flux time, pH, morphological composition, number of leucocytes. Zinc level was measured using spectrophotometric analysis. Trial of relation estimation between zinc concentration and number of live spermatozoa and pH of the semen was taken out. Any significant differences between zinc concentration in the semen from normospermic and oligospermic males were found. There was proved, that semen pH increase was correlated to zinc concentration decrement in the semen fluid.

Adult↗
PubMed1992

[Ultrasonographic pattern and levels of thyrotropin and antithyroid antibodies in patients with recurrent neutral goiter after subtotal thyroidectomy].

The study comprised 65 women (mean age 43 years) with the recurrent goiter after subtotal strumectomy. All patients were subjected to ultrasonographic examination using a sonograph Sonoline LM (Siemens) with 7.5 MHz head. The study was aimed at: 1) assessment of etiology of goiter recurrence, 2) assessment of changes in the thyroid parenchyma, 3) detection of the occurrence of heterogeneous structures, such as nodules, cysts and calcifications. It was found that goiter recurrence appeared mainly in the patients subjected to surgery because of neutral nodular goiter. The observed changes in the thyroid stump, such as heterogeneous structure of parenchyma, generalized cyst-like spaces and nodular structures mainly of mixed type or of solid, normo-echogenic or hyper-echogenic type, were associated with high levels of THS and the presence of antithyroid antibodies in blood serum. In patients with evidently high TSH levels and positive with respect to occurrence of antithyroid antibodies, the nodular structures were more numerous and of larger size. In can be concluded that ultrasonography provides a valuable noninvasive tool for the evaluation of morphological structure of the recurrent goiter.

Adult↗
PubMed1991

The levels of pituitary-testicular axis hormones and SHBG in active acromegaly following bromocriptine treatment.

Pituitary and testicular hormone secretion and sex-hormone binding globulin (SHBG) level were investigated in 15 males with active acromegaly in normal and hyperprolactinemic state. Basal serum folitropin (FSH) and lutropin (LH) levels did not change before and after the administration of bromocriptine and remained in normal range compared with those in healthy men. Serum total testosterone concentration and SHBG were decreased particularly in hyperprolactinemic patients, but their levels were significantly increased to the normal limits following bromocriptine application. Although slight changes in serum concentration of free testosterone (fT) and circadian rhythm of fT in saliva was observed before and following bromocriptine treatment, the statistical differences were not significant. The results of the present study suggest that in acromegaly the alterations in peripheral metabolism of sexual steroids may exist.

Acromegaly↗