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Biomedical subjects

F del Greco

Publications and source records attributed to F del Greco.

47 records · Page 3Linked to original sources
PubMed1969

Intrahepatic cholestasis due to azathioprine.

Severe intrahepatic cholestasis occurred 13 months following renal homotransplantation in a patient treated with azathioprine and prednisone. The patient had not received other drugs, surgery, anesthesia, or blood transfusions since transplantation. Extrahepatic biliary obstruction was excluded by laparotomy and operative cholangiography. Histologically, marked cholestasis was present with minimal necrosis and inflammation terminally. An awareness of this possible complication is important in the treatment of chronic liver disease with azathioprine.

Adult↗
PubMedDate not supplied

Preparation of bacteriologically safe bicarbonate concentrate for hemodialysis.

To determine whether bacteriologic hazards associated with bicarbonate concentrate may be reduced or prevented, evaluation of a system consisting of a mixing tank supplied with R.O. water and two separate storage tanks was undertaken. Bicarbonate was mixed on a schedule specific to usage and dispensed to the storage tanks from which it was drawn off into 2.5 gallon jugs for each treatment. The mixing tank was disinfected with hypochlorite solution (200 ppm) before each use. Storage tanks and 2.5 gallon jugs were disinfected weekly and sampled immediately before scheduled disinfection and after the longest storage time. The mixing tank was sampled for corresponding batches. A 1 ml inoculum of concentrate was plated onto tryptic soy sheep blood agar, incubated for 48 hours at 35 degrees C and colony counts/ml recorded. A total of 225 batches on a 10% sampling schedule were monitored. All cultures have grown less than 50 cfu/ml, which is less than AAMI standards for maximum allowable level for water and dialysate. Bacteriologically safe bicarbonate concentrate can be reliably produced using R.O. water, controlled storage times, and rigid disinfection schedules.

Bacteria↗
PubMedDate not supplied

The renin-angiotensin-aldosterone system in primary and secondary hypertension.

Important advances have been made in understanding the role of the renin-angiotensin-aldosterone system in the pathogenesis and diagnosis of hypertensive disorders. Measurement of plasma renin activity (PRA) and aldosterone is very important in the assessment of secondary hypertension. Hypertensions with increased PRA include renovascular hypertension, some cases of unilateral and bilateral renal parenchymal disease, malignant hypertension, hypertension associated with oral contraceptive agents, and renin-secreting tumors. Hypertension with decreased PRA is observed in four recognized types of primary aldosteronism: adenoma, bilateral hyperplasia, indeterminate aldosteronism, and glucocorticoid-responsive aldosteronism. Other conditions with hypertension and depressed PRA include ACTH and DOC secreting tumors, primary hyperpituitarism, syndromes of 17-hydroxylase and 11-beta-hydroxylase deficiency. Liddle's syndrome, licorice abuse, exogenous administration of mineralocorticoids, and preeclampsia.

Acute Kidney Injury↗
PubMedDate not supplied

Platelets and the hemolytic-uremic syndrome.

Clinical studies suggest that the microthrombi characteristically found in hemolytic-uremic syndrome (HUS) may be the consequence of an uncontrolled platelet-endothelial interaction. A defect in prostacyclin production which is corrected by normal plasma may be the fundamental pathogenic mechanism. For this reason, efforts should be made to confirm the recent case reports which suggest that plasma infusion or exchange may be more effective than hemostatic inhibitors in the achievement of clinical remission in HUS.

Anticoagulants↗
PubMedDate not supplied

Role of the laboratory in management of acute and chronic renal failure.

The initial assessment and differential diagnosis of acute renal failure is greatly facilitated by laboratory procedures of varying sensitivity and specificity; these are reviewed in detail. Patients with chronic renal failure receiving maintenance dialysis exhibit many laboratory abnormalities which may differ significantly between patients treated with hemodialysis and those receiving peritoneal dialysis. These are also reviewed.

Acute Kidney Injury↗