A combinatorial scaffold approach based upon a multicomponent reaction.
A combinatorial scaffolding procedure for the synthesis and spatial arrangement of tripartite structures was developed. [reaction: see text]
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Biomedical subjects
Fabio Bertozzi
Publications and source records attributed to Fabio Bertozzi.
One-pot three-component reaction for the synthesis of alpha-(aminoethyl)-alpha,beta-enones.
[reaction: see text] The synthesis of alpha-substituted alpha,beta-enones by a new metal iodide-promoted one-pot three-component reaction involving commercially available cyclopropyl ketones, aldehydes, and secondary amines followed by base treatment is described.
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A novel metal iodide promoted three-component synthesis of substituted pyrrolidines.
[reaction: see text] A new one-pot procedure for the synthesis of substituted pyrrolidine derivatives with commercially available cyclopropyl ketones, aldehydes, and amines by a metal iodide promoted three-component reaction was developed.
Aldehydes↗
Copper phosphoramidite catalyzed enantioselective ring-opening of oxabicyclic alkenes: remarkable reversal of stereocontrol.
[reaction: see text] An unprecedented copper phosphoramidite catalyzed enantioselective alkylative ring-opening reaction of oxabenzonorbornadiene derivatives with dialkylzinc reagents is reported. The reaction shows high levels of anti-stereoselectivity (up to anti/syn >99:1), complementary to the Pd(0)-catalyzed syn-selective ring-opening protocol, allowing a new entry to anti-dihydronaphthols with high enantioselectivity (up to 99% ee).
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Highly Enantioselective Regiodivergent and Catalytic Parallel Kinetic Resolution This work was supported by the Ministero dell'Università e della Ricerca Scientifica e Tecnologica (MURST, Roma) and by the University of Pisa. We gratefully acknowledge Merck for the generous financial support derived from the 2000 ADP Chemistry Award.
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Journal Article↗