Biomedical subjects

Fabiola M S Adam

Publications and source records attributed to Fabiola M S Adam.

2 recordsLinked to original sources

PubMedDate not supplied

Asymptomatic diabetes: the difference between population-based and office-based screening.

AIM: To compare the results between population-based and office-based diabetes screening. METHODS: In 1997, a population-based screening was performed on a group of government employees and retired subjects in the Makassar Municipality. Since the year 2000, we performed screening at the clinic. For clinical-based screening, we focused the screening on those with high risks for developing diabetes mellitus, i.e. all subjects aged > or =45 or those aged < 45 with one or more of the following abnormalities: obese (BMI > 25 kg/m2), elevated blood pressure (> or =140/90 mmHg in adults), family history of diabetes, previous identified IFG or IGT, HDL-cholesterol < or =35 mg/dl and/or triglyceride > or =250 mg/dL, and history of gestational diabetes mellitus or delivery of babies > or =4000 gram. For population-based screening, the criteria for diabetes mellitus was based on a single test 2-hours post load (75 gram glucose), while for office-based screening, the WHO l999 was used i.e. fasting and 2-hours post 75 gram glucose load (OGTT). RESULTS: During the screening in the population, 941 subjects were screened, 290 women and 651 men. There were 51 diabetic subjects, or a prevalence of 5.42%, 21 women or 7.24% of all women, and 30 men or 4.60% of all men. At the clinical setting, 907 were screened, 483 women and 424 men. Among these subjects, 155 fulfilled the diabetes criteria, with a prevalence of 17.1%. There were 78 diabetic women or 16.1% of all women, and 77 men or 18.2% of all men. If the diagnosis of diabetes mellitus in the clinical setting is based only on 2 hours post load (the same as for population-based) only 70 patients can be detected, for a prevalence of 7.7%, which is still higher compared to the results of the population-based screening. All figures obtained from the office-based screening were higher as compared to the population-based results. CONCLUSION: These results show that office-based screening detected more asymptomatic diabetes compared to population-based screening. It is suggested that early detection of asymptomatic diabetes is performed at the clinic, either at the hospital or doctor's private office.

Adult↗

PubMedDate not supplied

Fasting insulin, adiponectin, hs-CRP levels, and the components of metabolic syndrome.

AIM: in this study we report the relationship between fasting plasma insulin, C-reactive protein, adiponectin levels and the components of metabolic syndrome. METHODS: for the diagnosis of metabolic syndrome we used the modified NCEP ATP criteria for Asian people. Complete routine physical examinations were performed to all subjects including blood pressure, waist circumference. After 12-hours fasting, blood sample was taken for fasting plasma glucose, fasting insulin, and lipid profiles. Fasting insulin was determined by RIA, adiponectin by ELISA, and hs-CRP by sensitive immunometric assay. According to NCEP ATP III, the metabolic syndrome consists of five components. Subjects fulfilling the studied criteria were divided into five groups according to the component/components they had. RESULTS: during the study, 118 adult individuals can be covered, including 88 patients (68,8%) with metabolic syndrome. They consist of 19 subjects who had only 1 component, 21 subjects had 2 components, 31 subjects with 3 components, 34 subjects with 4 components, and 23 subjects had 5 component. All subjects were overweight/obese (BMI > 23 kg/m), but patients with metabolic syndrome were significantly more obese compared to the non-metabolic syndrome (p < 0.05). There was no significant difference in age among all individuals. Fasting insulin, hs-CRP levels is increasing with the increasing number of components of metabolic syndrome, being higher among those with 3-5 components, while adiponectin is decreasing with the number of the components. Fasting insulin 3,5+1,1 uU/ml, 3,6+1,4 uU/ml, 5,9+1,8 uU/ml, 7,8+2,1 uU/ml, 7,9+2,3 uU/ml respectively, hs-CRP 2,8+1,2 mg/L, 5.6+3.4 mg/L, 7.4+4.4 mg/L, 9.0+4.7 mg/L, 9.5+3,9 mg/L, and adiponectin 9.1+3.5 ng/ml, 8.6+1.6 ng/ml, 3.4+1.2 ng/ml, 3.2+1.3 ng/ml, 2.8+0.9 ng/ml in 3,4,5 components respectively. CONCLUSION: there is a relationship between the number of components of metabolic syndrome and the increasing levels of fasting insulin, and hs-CRP, and low levels of adiponectin. These may explain in part the risk of cardiovascular events among individuals with metabolic syndrome.

Adiponectin↗