Biomedical subjects

Fabrice Besacier

Publications and source records attributed to Fabrice Besacier.

3 recordsLinked to original sources

PubMed2006

A quick and automated method for profiling heroin samples for tactical intelligence purposes.

A computerized procedure is presented for the profiling and comparison of illicit heroin seizures. The system involves the derivation and gas chromatographic separation of five major constituents followed by a fully automatic data analysis and transfer to a PHP/MySQL database. Comparisons via the square cosine function between a single chromatographic profile and the whole database (several hundred of samples) are performed in a few seconds. Advantages of this profiling method compared to the classical minor constituents one are discussed.

Journal Article↗

PubMed2003

Optimization of extraction parameters for the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets.

The extraction of impurities from illegally produced 3,4-methylenedioxymethamphetamine (MDMA) has been studied in order to optimize the parameters. Two different MDMA samples were used. Particular attention was paid to the influence of the pH, the evaporation step, and the sample storage. The method used was an extraction of impurities by diethyl ether from a buffer solution at pH 11.5, followed by gas chromatography (GC) mass spectrometric (MS) analyses after a dryness concentration under monitored conditions of the ethereal extract. Repeat extractions of the same sample gave an average relative standard deviation (RSD) of less than 8.5% within day and less than 10.5% between days.

Journal Article↗

PubMed2002

A contribution to the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets.

A profiling method for the identification of impurities found in seized 3,4-methylenedioxymethamphetamine (MDMA) tablets is presented. Impurities of interest are extracted from an alkaline solution (pH 12.8) by diethyl ether and submitted to gas chromatography (GC)-mass spectrometry (MS) analyses. Identification of impurities is performed by electron impact ionization (Ei) mass spectrometry and confirmation by positive chemical ionization (Ci+) MS or, when possible, MS/MS (MS(2)). Repeat extractions of the same sample give an average relative standard deviation (R.S.D.) of less than 8% within the same day and 15% between days (results were obtained after normalization by the sum of peak areas, each one being acquired by selected ion monitoring (SIM)). Possible application toward batch comparison of samples is discussed. Chromatographic profiles are compared using the cosine function for evaluating similarity and/or dissimilarity among exhibits.

Drug Contamination↗