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Biomedical subjects

Fang Hou

Publications and source records attributed to Fang Hou.

3 recordsLinked to original sources

Amodal completion impairs stereoacuity discrimination.

Visual stimulus configuration can influence elementary visual processes. We provide empirical evidence to demonstrate this effect in stereoscopic depth discrimination. Two vertically aligned bars were presented in stereo such that one of them was closer to the human observer. Observers discriminated which of the two was closest. In the first, "occluded" condition, a horizontal bar, positioned closest in depth to the observer, was added to the display such that the two vertical bars perceptually completed to form a whole by connecting together behind the horizontal bar. In the second, control condition, the horizontal bar was placed furthest away from the observer such that there was a visible gap between the two vertical bars, which could no longer complete perceptually. We measured observers' psychometric functions using the method of constant stimuli, and found that their discrimination sensitivity d' was smaller when the two vertical bars perceptually completed than when they did not. We used a simple model to illustrate that when the two vertical bars perceptually completed, they also tended to be perceived as coplanar in the fronto-parallel plane. This consequence of completion made it more difficult to discriminate any difference in depth between the two vertical bars.

Analysis of Variance↗

Clinical study for alleviating opiate drug psychological dependence by a method of ablating the nucleus accumbens with stereotactic surgery.

The aim of this study was to explore a new way of treating drug addiction by ablating the nucleus accumbens (NAC), which has a close relationship with drug-induced psychological dependence, using stereotactic surgery, blocking the mesocorticolimbic dopamine circuit, alleviating craving for drugs and lowering the relapse rate after detoxification. On the basis of animal experiments, stereotactic surgery was performed in 28 patients by making a lesion in the NAC bilaterally to treat opiate drug dependence. Indications, the criterion of therapeutic effect, treatment process and the therapeutic and safety evaluation index of the surgery were formulated particularly. The mean follow-up period was 15 months. Relapse has not occurred in 11 cases up till now. Drug-free time in these patients has been more than half a year in 4 cases (more than a year in 3 cases), and less than half a year in 7 cases. Relapse occurred in 15 cases after surgery. Drug-free time in these patients was more than half a year in 3 cases, between 1 month and half a year in 10 cases and less than 1 month in 2 cases. The therapeutic effect was excellent in 7 cases (26.9%), good in 10 cases (38.5%) and poor in 2 cases (7.7%). Another 7 cases were still under investigation at the time of writing. Relapse rates after surgery were 7.7, 38.5 and 57.5% within 1 month, between 1 month and half a year and after more than half a year, respectively. There were no common complications of surgery such as intracranial hematoma or infection in these patients after operation. Character type was changed slightly in 2 cases, and 4 cases suffered temporary memory loss, which did not affect their daily lives and learning function. They all recovered within 1 month. There were different degrees of effectiveness of treating drug addicts' psychological dependence by making lesions in the NAC bilaterally with stereotactic surgery. No particular complications occurred. The operation is safe and feasible. The mean follow-up time in this study was 15 months. The effectiveness was satisfactory. The relapse rate of drug addicts after detoxification was clearly reduced.

Follow-Up Studies↗

A randomized, controlled clinical trial on meropenem versus imipenem/cilastatin for the treatment of bacterial infections.

OBJECTIVE: To evaluate the efficacy and safety of meropenem in Chinese patients, we conducted a study for the treatment of patients with lower respiratory tract infections, urinary tract infections and other infections. METHODS: A total of 182 hospitalized patients were enrolled in the study. 90 patients received 500 mg meropenem every 12 hours (or 1 g every 12 hours if necessary) and 92 patients received imipenem/cilastatin 500 mg/500 mg every 12 hours (or 1 g every 12 hours if necessary) by intravenous infusion. The duration of treatment was 7 - 14 days for both groups. RESULTS: Seventy of 90 cases receiving meropenem and 70 of 92 cases receiving imipenem/cilastatin were assessable for clinical efficacy. The overall efficacy rates were 90% for the meropenem group and 87% for the imipenem/cilastatin group, and the bacterial eradication rates were 86% in both groups. 93 (76%) of 123 strains isolated from patients produced beta-lactamases. Adverse drug reactions were evaluated in 72 cases in the meropenem group and 70 cases in the imipenem/cilastatin group. The adverse drug reaction rates were 9.7% and 8.6%, respectively. The results showed that there were no statistical differences between these two groups (P > 0.05). CONCLUSION: Meropenem is effective and safe for the treatment of bacterial infections caused mainly by beta-lactamase-producing strains.

Adult↗