Biomedical subjects

Farzad Kamalabadi

Publications and source records attributed to Farzad Kamalabadi.

4 recordsLinked to original sources

PubMed2006

Asymptotically optimal blind estimation of multichannel images.

Optimal estimation of a two-dimensional (2-D) multichannel signal ideally decorrelates the data in both channel and space and weights the resulting coefficients according to their SNR. Many scenarios exist where the required second-order signal and noise statistics are not known in which the decorrelation is difficult or expensive to calculate. An asymptotically optimal estimation scheme proposed here uses a 2-D discrete wavelet transform to approximately decorrelate the signal in space and the discrete Fourier transform to decorrelate between channels. The coefficient weighting is replaced with a wavelet-domain thresholding operation to result in an efficient estimation scheme for both stationary and nonstationary signals. In contrast to optimal estimation, this new scheme does not require second-order signal statistics, making it well suited to many applications. In addition to providing vastly improved visual quality, the new estimator typically yields signal-to-noise ratio gains 12 dB or higher for hyperspectral imagery and functional magnetic resonance images.

Algorithms↗

PubMed2006

A regularized inverse approach to ultrasonic pulse-echo imaging.

An inverse-theoretic approach to ultrasonic pulse-echo imaging based on nonquadratic regularization is presented, and its effectiveness is investigated computationally by: 1) evaluating the quality of the reconstruction of speckle-based images as a function of the transmit-receive bandwidth and focal number of the transducer; 2) comparing the reconstructed images with those obtained by using conventional B-mode imaging. The L-curve and the generalized cross-validation methods were evaluated as automatic regularization parameter selection techniques. The inversion using regularization produced better results than conventional B-mode imaging for high signal-to-noise ratios (SNRs). A lower bound of 30 dB for the SNR was found for this study, below which several of the image features were lost during the reconstruction process in order to control the distortion due to the noise.

Algorithms↗

PubMed2005

Comparative performance analysis of time-frequency distributions for spectroscopic optical coherence tomography.

The analysis of spectroscopic optical coherence tomography (SOCT) signals suffers the trade-off between time resolution and frequency resolution. Various joint time-frequency distributions (TFDs) can optimize this trade-off. Synthesized signals were generated and experimentally acquired data were obtained to compare and validate several different TFDs under different SOCT imaging schemes. Specific criteria were designed to quantify the TFD performance. We found that different SOCT imaging schemes require different optimal TFDs. Cohen's class TFDs generate the most compact time-frequency (TF) analysis, while linear TFDs offer the most reliable TF analysis. In both cases, if some prior information is known, model-based TF analysis can improve the performance.

Algorithms↗

PubMed2005

Deconvolution methods for mitigation of transverse blurring in optical coherence tomography.

Imaging resolution in optical coherence tomography (OCT) is a key determinant for acquiring clinically useful optical biopsies of tissues. In contrast to light or confocal microscopy, the axial and transverse resolutions in OCT are independent and each can be analyzed individually. A method for mitigating transverse blurring and the apparent loss of transverse resolution in OCT by means of Gaussian beam deconvolution is presented. Such a method provides better representation of a specimen by using known physical parameters of a lens. To implement this method, deconvolution algorithms based on a focal-dependent kernel are investigated. First, the direct inverse problem is investigated using two types of regularization, truncated singular value decomposition, and Tikhonov. Second, an iterative expectation maximization algorithm, the Richardson-Lucy algorithm, with a beam-width-dependent iteration scheme is developed. A dynamically iterative Richardson-Lucy algorithm can reduce transverse blurring by providing an improvement in the transverse point-spread-function for sparse scattering samples in regions up to two times larger than the confocal region of the lens. These deblurring improvements inside and outside of the confocal region, which are validated experimentally, are possible without introducing new optical imaging hardware or acquiring multiple images of the same specimen. Implementation of this method in sparse scattering specimens, such as engineered tissues, has the potential to improve cellular detection and categorization.

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