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Biomedical subjects

Fei-Peng Lee

Publications and source records attributed to Fei-Peng Lee.

13 recordsLinked to original sources
PubMed2006

Vascular endothelial growth factor and children featuring nasal polyps.

BACKGROUND: The aim of this study is to explore the expression of vascular endothelial growth factor within nasal polyps, and the implication of such expression as regards the development of nasal polyps amongst children. MATERIAL AND METHODS: Sixty children suffering from chronic rhinosinusitis were enrolled in this study. Amongst them, 30 patients featured rhinosinusitis with associated nasal polyps. A biopsy specimen was taken from the stalk or the base of the nasal polyp for nasal-polyp sufferers, and the ethmoid sinus for study participants who featured no nasal polyps. The primary lesions biopsied were immunohistochemically stained with a specific endothelial-cell marker and also stained for the presence of vascular endothelial growth factor. The specific level of vascular endothelial growth factor and the mean number of blood vessels present in a visual microscopic (biopsied-specimen) field were calculated under light microscopy (x400). RESULTS: The number of vascular endothelial growth factor-expressing cells for the nasal-polyp group and for the sinusitis group was, respectively, 20.8+/-4.0 and 11.5+/-3.4 per visual field. Correspondingly, the mean intra-polyp blood-vessel density for the nasal-polyp group and that for the control group was, respectively, 10.5+/-2.6 and 5.0+/-1.9 per visual field. The mean intra-polyp blood-vessel density and the number of vascular endothelial growth factor-expressing cells proved to be significantly greater amongst individuals from the nasal-polyp group than was the case for their analogs from the sinusitis group (P<0.01, for both). The presence of vascular endothelial growth factor was found to be distributed predominantly within the vascular endothelium and the mast cells of polyp tissue. In addition, the level of vascular endothelial growth-factor expression and the mean blood-vessel count per field correlated significantly for nasal-polyp tissue (P<0.001). Furthermore, the relative size of nasal polyps correlated significantly with the number of (intra-polyp) vascular endothelial-cell growth factor-expressing cells and the mean blood-vessel density (P<0.05, for both). CONCLUSION: The level of expression of vascular endothelial-cell growth factor (VEGF) and the mean blood-vessel density were shown to be significantly greater within nasal polyps than within corresponding sinusitis mucosa. Clinically, the expression of both of these parameters correlated well with the relative size of nasal polyps. Vascular endothelial growth factor participates in the formation of nasal polyps amongst children suffering from chronic rhinosinusitis (CRS).

Adolescent↗
PubMed2006

Complications in children with long-term cochlear implants.

OBJECTIVES: To evaluate the complications in children who underwent cochlear implantation between 1991 and 2002 at Chi Mei Medical Center, Taipei Medical University. METHOD: The medical records of 169 cases of pediatric cochlear implants from 1991 to 2002 with a follow-up period of 3-11 years were reviewed for demographics and complications. A follow-up phone call and clinical visits were performed to determine the long-term results. RESULTS: The medical-surgical complications were facial nerve stimulation, transient dizziness, flap breakdown, minor change of taste, cholesteatoma, otitis media with effusion and mastoiditis. The device-related complications included 4 device failures and 1 device breakage in a traffic accident. CONCLUSION: Chronic otitis media and cholesteatoma developed in children as long-term complications and surgical challenges. Nevertheless, cochlear implantation surgery in children is a reliable and safe procedure with a low percentage of severe complications. To prevent cholesteatoma formation, parents are advised to schedule a regular ENT consultation at least yearly for early identification and treatment in the stages of acute otitis media or drum retraction.

Child↗
PubMed2006

Pigmented nevus of the external auditory canal.

OBJECTIVE: To present the clinical experience during an 18-year period of a series of 11 cases of pigmented nevus of the external auditory canal (EAC). STUDY DESIGN AND SETTING: Retrospective medical review of 11 consecutive patients with lesions seen in 2 departments of otolaryngology in Taiwan. RESULTS: 12 pigmented nevi, 2 to 12 mm (average, 6.4 mm) in diameter, were excised under otomicroscopy, and the EAC was packed with a temporary Penrose stent. One large lesion developed a postobstructive external auditory canal cholesteatoma (EACC). Histopathologic examination revealed 11 intradermal nevi and 1 compound nevus. There have been no recurrences or stenoses of EACs after 3 months to 17 years (average, 6 years) of follow-up. CONCLUSION: If a pigmented nevus causes symptoms, especially when it is large enough to obstruct the lumen of the EAC and has the possibility of developing into an EACC, it should be excised. EBM RATING: C-4.

Adolescent↗
PubMed2006

An alternative use of video-telescopic guidance for insertion of myringotomy tube.

The insertion of a myringotomy tube is a common ENT procedure. Traditionally, this procedure is performed under otomicroscopic view. In this paper I describe a technique using rigid endoscopy with the Hopkins rod and a video monitor as a visual aid for the insertion of myringotomy tube in older children and adults. The technique is safe and effective; it allows demonstration of the entire tympanic membrane during surgery and also enables better teaching of the procedure than does the otomicroscope.

Adolescent↗
PubMed2005

Cartilaginous choristoma of the bony external auditory canal: a study of 36 cases.

OBJECTIVE: The study goal is to present the clinical data of 36 cases of heterotopic cartilaginous mass in the bony external auditory canal and to clarify the terminology used to describe this clinical entity. STUDY DESIGN AND SETTING: We conducted a medical record review of 36 consecutive patients with lesions (26 of which were excised) seen at two Departments of Otolaryngology in Taiwan. RESULTS: Histopathological examination revealed that all 26 excised lesions were composed of mature hyaline cartilage, and on this basis, cartilaginous choristoma was diagnosed. CONCLUSION: The presence of a heterotopic cartilaginous mass in the bony external ear canal is not as rare as it was once thought to be. The descriptive term "cartilaginous choristoma" rather than "chondroma" may be more appropriate for these lesions. EBM RATING: C.

Adolescent↗
PubMed2004

Pediatric Kikuchi-Fujimoto disease masquerading as a submandibular gland tumor.

Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a rare disorder that typically affects the cervical lymph nodes. The disease usually occurs in women in their late 20s or early 30s. Reports in the pediatric literature are sparse. Most authors consider Kikuchi-Fujimoto disease as a self-limiting disorder that requires no specific management but long-term follow-up. The clinical features of Kikuchi-Fujimoto disease are easily confused with other less-benign conditions. Thus, an early biopsy is instrumental in making definite diagnosis and preventing unnecessary investigations. We describe a case of Kikuchi-Fujimoto disease in an 8-year-old boy which presenting as a submandibular gland tumor. The case illustrates the clinical features of this unusual condition and emphasizes the potential confusion with other diagnoses.

Biopsy↗
PubMed2004

Removal of fish bones in the oropharynx and hypopharynx under video laryngeal telescopic guidance.

OBJECTIVE: The study goal was to present the technique and results of removal of fish bones in the oropharynx and hypopharynx under video laryngeal telescopic guidance. Study design and set From January 2001 to December 2002, a total of 27 patients with fish bones lodged in the oropharynx and hypopharynx were studied at the ENT Department of Taipei Medical University Hospital. RESULTS: All fish bones were removed smoothly without necessitating further procedures at the time of the initial clinical examination and had an uneventful clinical course. CONCLUSION: Removal of fish bones lodged at the tongue base, vallecula, and hypopharynx under video laryngeal telescopic guidance has the advantages of good illumination, clear visualization, and precise extraction.The technique has also proven to be efficient, safe, well tolerated, and with low morbidity. SIGNIFICANCE: Removal of the fish bones from difficult areas in oropharynx and hypopharynx with this technique can reduce the use of direct laryngoscope under general anesthesia.

Adult↗
PubMed2003

Measurement of tongue movement during vowels production with computer-assisted B-mode and M-mode ultrasonography.

OBJECTIVES: We sought to apply B- + M-mode ultrasonography in combination with the cushion-scanning technique (CST) in quantitative analysis of tongue movement during vowel articulation. STUDY DESIGN AND SETTING: Twenty normal persons (10 women and 10 men) were enrolled in this study. Each individual was asked to enunciate 5 vowels:/e/, /i/, /aI/, /o/, and /ju/. A noninvasive diagnostic technique, computer-assisted B-mode plus M-mode ultrasonography, was used in combination with the CST to assess their tongue movement. The sonographic signals were recorded on a video recorder and then transferred to a personal computer via a frame grabber for digital assessment. RESULTS: M-mode images show an amplitude-time diagram, whereas B-mode images reveal midsagittal tongue configuration. The ranges of tongue movement in midsagittal plane in male speakers during production of the vowels /e/, /i/, /aI/, /o/, and /ju/ were 8.29 +/- 1.76, 4.00 +/- 0.78, 13.82 +/- 2.86, 14.05 +/- 1.63, and 6.72 +/- 1.66 mm, respectively; for female speakers, the averages were 7.19 +/- 0.92, 3.36 +/- 1.31, 12.74 +/- 2.16, 12.86 +/- 2.18, and 7.11 +/- 2.09 mm, respectively. CONCLUSIONS: The computer-assisted B-mode plus M-mode ultrasonography in combination with the CST provides a standardized and quantifiable ultrasonographic examination for the clinical investigation of tongue movement during vowel articulation. In our study group, there was no difference in the thickness of tongue or the range of tongue movement in midsagittal plane during articulation of the selected vowels between males and females. Further exploration can be extended in the field of speech research by this valuable tool.

Adult↗
PubMedDate not supplied

Intraparotid Kikuchi-Fujimoto disease masquerading as a parotid gland tumor.

The Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis, is a self-limiting lesion of unknown cause first described in 1972 independently by Kikuchi and Fujimoto et al. This self-limiting disorder usually occurs in Asian women in their late 20s or early 30s. Typically, it runs a benign course and appears to resolve spontaneously 1 to 6 months after definite diagnosis. The Kikuchi-Fujimoto disease usually manifests as a localized cervical lymphadenopathy; therefore, most patients with this disease are seen in ears, nose, and throat practice. Nodal involvement other than in the neck area or extranodal involvement is rare. In this situation, however, the Kikuchi-Fujimoto disease is easily confused with other less-benign conditions. We describe a case of Kikuchi-Fujimoto disease in a 30-year-old man that presented as a parotid gland tumor. This is the third study to document intraparotid Kikuchi-Fujimoto disease in the English literature. Our report illustrates the clinical features of this unusual condition and emphasizes potential confusion with other diagnoses.

Adult↗