A synthetic receptor for phosphocholine esters.
A bifunctional Zn-salen modified cavitand, reminiscent of the enzyme phospholipase C, shows high efficiency and synergic effect in the binding of the phospholipid DOPC.
Binding Sites↗
Biomedical subjects
Felix H Zelder
Publications and source records attributed to Felix H Zelder.
Cavitand templated catalysis of acetylcholine.
A Zn-salen-modified cavitand templates the catalytic formation of acetylcholine from choline and acetic anhydride.
Acetic Anhydrides↗
DNA-templated catalysis using a metal-cleavable linker.
Catalytic release of carboxylates from their 8-hydroxyquinoline esters by Cu(II) complexes, both attached to peptide nucleic acid strands, is triggered by complementary DNA.
Carboxylic Acids↗
Sequence selective hydrolysis of linear DNA using conjugates of Zr(IV) complexes and peptide nucleic acids.
A series of conjugates of peptide nucleic acids (PNA) and Zr(IV) complexes was prepared. Their ability to hydrolyze DNA was tested using MALDI-TOF mass spectrometry and HPLC. The most efficient artificial restriction enzyme found, PNA conjugate with Zr(IV) complex of tris(hydroxymethyl)-aminomethane, cleaves DNA targets sequence selectively in close proximity to the Zr(IV) complex. It was demonstrated that cleavage products are substrates of terminal transferase.
Base Sequence↗