Biomedical subjects

Ferda Oner

Publications and source records attributed to Ferda Oner.

4 recordsLinked to original sources

PubMed2004

Immunoglobulins and complement components in patients with lung cancer.

Based on data providing a correlation between immunoglobulin or complement components levels and malignancies and specific disease parameters, we examined the possible correlation between the immunoglobulins, complement component levels and the stage of disease and the survival of patients. Sera from 55 patients with lung cancer and 22 healthy donor were assayed in order to evaluate the concentration of IgG, IgA, IgM, IgE, C3, C4. No considerable differences were found between the levels of immunoglobulins in patients with carcinoma of the lung versus subjects in the control group. Complement components (C3 and C4) levels were elevated in cancer patients with different cell types compared with levels in the control group. No statistically significant differences were found between the levels of the studied parameters and the stage of the disease and the survival time of patients. Our study confirm the hypothesis that malignant tumours contribute to elevation of complement components levels but additional studies are needed for demonstrating the prognostic value of immunoglobulin and complement components levels in lung cancer patients.

Adenocarcinoma↗

PubMed2003

[Genetic risk factors of venous thromboembolism].

Up to date several hereditary disorders have been identified as prothrombic risk factors. The most common inherited thrombotic disorders include activated protein C resistance (factor V Leiden), prothrombin G20210A mutation, hyperhomocysteinemia, deficiencies of protein C, protein S, antithrombin III, and thrombomodulin. This article focuses on the clinical and the laboratory aspects of some of the inherited venous thrombotic disorders including the factor V Leiden, prothrombin G20210A mutation and protein S deficiency.

Adult↗

PubMed2003

[Occupational asthma].

In the work places the worker may be exposed to environmental materials and substances that in some cases trigger respiratory problems. In this ambience, asthma is a common occupational problem that far exceeds other causes of occupational pulmonary disease. The epidemiology and the predisposing factors of occupational asthma, some of agents that causes occupational asthma, and the diagnosis of the disease will be reviewed in this brief discussion.

Asthma↗

PubMedDate not supplied

Occupational asthma in the furniture industry: is it due to styrene?

BACKGROUND: Styrene, a volatile monomer, has been reported as a cause of occupational asthma in a few case reports. OBJECTIVE: The aim of this study was to investigate the risk for asthma in relation to exposure to styrene in a large number of workers. METHODS: A total of 47 workers with a history of exposure to styrene were included in the study. To establish whether asthma was present, each patient underwent a clinical interview, pulmonary function testing and bronchial challenge with methacholine. Specific bronchial challenges with styrene and serial peak expiratory flow (PEF) measurement at home and at work were carried out in subjects with a diagnosis of asthma to evaluate the relationship between their asthma and exposure to styrene in the workplace. RESULTS: Among the 47 subjects, 5 workers had given a history of work-related symptoms, and 3 of them had a positive methacholine challenge test. Specific bronchial challenges with styrene and serial PEF measurement were subsequently carried out in these 3 subjects. Although provocation tests with styrene were negative in the 3 workers, 1 worker had PEF rate records compatible with occupational asthma. CONCLUSION: We established one patient with occupational asthma from a group of people who have excessive styrene exposure. This finding may be suggestive but is not conclusive about the causative role of styrene in occupational asthma. Since styrene is a frequently used substance in the furniture industry, it is worth performing further studies to investigate the relationship between styrene and occupational asthma.

Adult↗