PubMed Health⌕ Search

Biomedical subjects

Fereidoun Azizi

Publications and source records attributed to Fereidoun Azizi.

At least 19 recordsLinked to original sources
PubMed2006

The prospective association of general and central obesity variables with incident type 2 diabetes in adults, Tehran lipid and glucose study.

OBJECTIVE: To investigate which anthropometric index is the best predictor of diabetes in relation to age. METHODS: In this longitudinal study 4479 non-diabetic men and women aged > or =20 years were followed for 3.6 years. Diabetes with its risk factors and obesity were defined according to the ADA and the WHO criteria, respectively. Logistic regression analysis was used to estimate the odds ratio (OR) of developing diabetes in model 1 including only the anthropometric measure and in model 2 adjusted for common diabetes risk factors and in model 3 adjusted for other anthropometric indices plus all the variables in model 2. RESULTS: A total of 166 new cases of type 2 diabetes were diagnosed. In subjects aged <60 years general obesity and high waist-to-hip ratio (WHR) predicted diabetes in all three models with OR of 2.4 and 2.6 in model 3, respectively, while high waist circumference (WC) lost it association with diabetes in the full model. In subjects aged > or =60 years, however, high WC was the only independent predictor of diabetes in model 3 with OR of 3.8 while high WHR and general obesity predicted diabetes in models 1 and 2, respectively. CONCLUSION: General obesity and high WHR in Iranian subjects aged <60 years and high WC in older ones are the important predictors of type 2 diabetes.

Adult↗
PubMed2006

Independent and inverse association of hip circumference with metabolic risk factors in Tehranian adult men.

OBJECTIVE: To evaluate the relationship between hip circumference and metabolic risk factors in an urban adult population of Tehranian men. METHODS: In this population-based cross-sectional study, a representative sample of 4040 men aged 18-74 years was assessed in 1998. Demographic data were collected; anthropometric indices and blood pressure were measured according to standard protocol. Hypertension was defined based on Joint National Committee VI. Biochemical analysis was conducted on fasting blood samples. Diabetes was defined as fasting plasma glucose > or =126 mg/dl or 2 h plasma glucose > or =200 mg/dl. Lipid disorders and components of metabolic syndrome were considered based on Adult Treatment Panel III. RESULTS: Higher hip circumference was associated with lower levels of serum total cholesterol, serum triglyceride, fasting plasma glucose, and 2-h plasma glucose. Subjects in the top quintile of hip circumference had higher values of serum HDL-cholesterol concentration compared to those in the lower category. After adjustment for potential confounding variables, a significant decreasing trend was observed among hip circumference quintile categories for odds of having hypercholestrolemia (odds ratios among quintiles: 1.00, 0.83, 0.76, 0.66, 0.51, respectively, P for trend = 0.03), diabetes (1.00, 0.74, 0.55, 0.29, 0.20, P for trend = 0.01), and abnormal glucose homeostasis (1.00, 0.82, 0.68, 0.46, 0.36, P for trend = 0.01). Individuals in the upper category of hip circumference had lower odds of having low serum HDL-cholesterol (0.91 vs. 1.00) and high serum triglyceride levels (0.73 vs. 1.00) compared to those in the lowest category. CONCLUSION: Hip circumference is independently and negatively associated with metabolic risk factors.

Adolescent↗
PubMed2006

Prevalence of the hypertriglyceridemic waist phenotype in Iranian adolescents.

BACKGROUND: No evidence exists regarding the prevalence of the hypertriglyceridemic waist phenotype in adolescents. We aimed to evaluate the prevalence of this phenotype in a representative sample of Tehranian adolescents. METHODS: Anthropometry and serum triglyceride concentration were assessed in a population-based cross-sectional study of 3036 Tehranian adolescents (1413 male and 1623 female) aged 10 to 19 years in 1998. Hypertriglyceridemic waist phenotype was defined as concurrently having serum triglyceride concentration>or=110 mg/dL and waist circumference equal to or greater than the 90th percentile for age and gender. Overweight (>or=95th percentile) and at risk for overweight (>or=85th to <95th percentile) was defined based on the standardized percentile curves of body mass index suggested for Iranian adolescents. RESULTS: The prevalence of the hypertriglyceridemic waist phenotype was 6.4% (95% confidence interval [CI]=5.5-7.2) among Tehranian adolescents (males 7.3%, CI=5.9-8.7; females 5.6%, CI=4.4-6.7). When examined by body mass index category, 38.7% of overweight adolescents had a hypertriglyceridemic waist compared to 7.7% of adolescents at risk for overweight and 0.7% of adolescents at normal weight (p=0.001). CONCLUSIONS: This study provides evidence showing that the hypertriglyceridemic waist phenotype is prevalent among 6.5% of Tehranian adolescents, and particularly among overweight adolescents.

Adolescent↗
PubMed2006

High prevalence of the metabolic syndrome in Iranian adolescents.

OBJECTIVE: No evidence exists regarding the prevalence of the metabolic syndrome in adolescents in Middle Eastern countries. We aimed to evaluate the prevalence of the metabolic syndrome in a representative sample of Iranian adolescents. RESEARCH METHODS AND PROCEDURES: Anthropometry, biochemical measurements, and blood pressure were assessed in a population-based cross-sectional study of 3036 Iranian adolescents (1413 boys and 1623 girls) 10 to 19 years of age. Metabolic syndrome was defined according to modified Adult Treatment Panel III definition. Overweight (> or = 95th percentile) and at risk for overweight (> or = 85th to < 95th percentile) was defined based on the standardized percentile curves of BMI suggested for Iranian adolescents. RESULTS: The prevalence of the metabolic syndrome was 10.1% (95% confidence interval: 9.0 to 11.1) among Iranian adolescents (boys: 10.3%, 8.6 to 11.8; girls: 9.9%, 8.4 to 11.3). Overall, low serum high-density lipoprotein-cholesterol and high serum triglycerides were the most common components of the metabolic syndrome (42.8% and 37.5%, respectively). Overweight subjects had the highest proportion of metabolic syndrome compared with those at risk for overweight and those with normal weight (boys: 41.1% vs. 11.4% and 3.0%, respectively, p < 0.01; girls: 43% vs. 15.2% and 5.0%, respectively, p < 0.01). DISCUSSION: This study provides evidence showing a high prevalence of the metabolic syndrome in Iranian adolescents, particularly among overweight adolescents.

Adolescent↗
PubMed2006

Comparative evaluation of anthropometric measures to predict cardiovascular risk factors in Tehranian adult women.

OBJECTIVE: To compare the ability of waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) to predict cardiovascular risk factors in an urban adult population of Tehranian women. DESIGN: Population-based cross-sectional study. SETTING: Tehran, the capital of Iran. SUBJECTS: This study was conducted on 5073 women aged 18-74 years, participants of the Tehran Lipid and Glucose Study. Demographic data were collected. Anthropometric indices were measured according to standard protocols. Cut-off points of BMI, WC, WHR and WHtR were considered as 25 kg m(-2), 80 cm, 0.8 and 0.5, respectively. Blood pressure was measured and hypertension was defined based on the sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Biochemical analyses were conducted on fasting blood samples. Diabetes was defined as fasting plasma glucose > or = 126 mg dl(-1) or 2-hour plasma glucose > or = 200 mg dl(-1) and dyslipidaemia based on the third report of the National Cholesterol Education Program Expert Panel. The presence of 'at least one risk factor' from the three major cardiovascular risk factors (hypertension, dyslipidaemia and diabetes) was also evaluated. RESULTS: Mean (+/-standard deviation) age of women was 39.9+/-14.6 years; mean BMI, WC, WHR and WHtR were 27.1+/-1.5 kg m(-2), 86.5+/-13.5 cm and 0.83+/-0.08 and 0.55+/-0.08, respectively. Of the four anthropometric measures, WC had the highest sensitivity and specificity to identify subjects with risk factors in both the 18-39 year and the 40-74 year age categories. WC was seen to have a higher percentage of correct prediction than BMI, WHR and WHtR. CONCLUSION: It is concluded that WC is the best screening measure for cardiovascular risk factors, compared with BMI, WHR and WHtR, in Tehranian adult women.

Adolescent↗
PubMed2006

Dietary diversity score and cardiovascular risk factors in Tehranian adults.

AIM: To evaluate the relationship between dietary diversity score (DDS) and cardiovascular risk factors in Tehranian adults. METHODS: In this population-based cross-sectional study, a representative sample of 581 subjects (295 males and 286 females) aged over 18 years, residents of Tehran, participated. Hypercholesterolaemia, hypertriglyceridaemia and low high-density lipoprotein cholesterol were defined according to the Adult Treatment Panel III guidelines of the National Cholesterol Education Program. Diabetes was defined as fasting plasma glucose concentration > or = 126 mg dl(-1) or 2-h post challenge glucose concentration > or = 200 mg dl(-1). Hypertension was defined on the basis of the sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Dietary diversity was defined according to the Diet Quality Index revised. RESULTS: Mean (+/- standard deviation) DDS was 6.15 +/- 1.02. The probability of having diabetes (odds ratio (OR) among quartiles: 1.45, 1.26, 1.11 and 1.00, respectively; P for trend = 0.04) and hypertriglyceridaemia (OR = 1.41, 1.23, 1.05 and 1.00, respectively; P for trend=0.04) decreased with increasing quartile of the diversity score for whole grains. The probability of having obesity (OR among quartiles: 1.39, 1.06, 1.03 and 1.00, respectively; P for trend = 0.03), hypercholesterolaemia (OR = 1.46, 1.28, 1.11 and 1.00, respectively; P for trend = 0.03), hypertension (OR = 1.32, 1.17, 1.13 and 1.00, respectively; P for trend = 0.03) and high low-density lipoprotein cholesterol (LDL-C) (OR = 1.25, 1.12, 1.07 and 1.00, respectively; P for trend = 0.04) decreased with increasing quartile of the diversity score for vegetables. The probability of having hypercholesterolaemia, high LDL-C, hypertension and diabetes decreased with quartile of the DDS. But the probability of being obese increased with quartile of the DDS (P for trend = 0.03). CONCLUSION: DDS was inversely associated with cardiovascular risk factors in this cross-sectional study. Increased diversity scores of diets, to increase the variety score for vegetables, may be emphasised in programmes attempting to bring about changes in lifestyle.

Adult↗
PubMed2006

Dietary diversity within food groups: an indicator of specific nutrient adequacy in Tehranian women.

OBJECTIVE: To determine the relationship between dietary diversity within food groups and dietary diversity score and the probability of nutrient adequacy in Tehranian women. DESIGN: Cross-sectional study assessing food intake by two 24-hour recalls questionnaires on two different occasions. Dietary diversity was defined according to diet quality index revised. The mean probability of adequacy across 14 nutrients was calculated using the Dietary Reference Intakes. SETTING: District 13 of Tehran, Iran. SUBJECTS: 286 females aged 18-80 years. RESULTS: Whole grain diversity score mostly correlated with protein and vitamin B2 (r = 0.35, p < 0.05). Fruit diversity score was correlated with vitamin C (r = 0.44, p < 0.05). Dairy diversity score was correlated with calcium intake (r = 0.54, p < 0.05). Meat diversity score was correlated with protein intake (r = 0.34, p < 0.05). Most subjects failed to meet vitamin B6, zinc, magnesium, calcium, copper, and vitamin B12 adequacy. Energy intake was a strong predictor of the mean probability of adequacy in models controlled for age, BMI, education level and job status (model R2 = 0.53). Adding the number of servings from each of the food group to the models significantly improved the model fit (model R(2) = 0.59). Adding the dietary diversity score improved the model fit significantly (model R2 = 0.64). Dairy diversity score had the strongest association with improved nutrient adequacy. CONCLUSION: Dietary diversity score is a useful indicator of specific nutrient adequacy in Tehranian women. However, to determine the adequacy of a specific nutrient, the diversity scores of specific food groups might be taken into account.

Adolescent↗
PubMed2006

Clustering of metabolic abnormalities in adolescents with the hypertriglyceridemic waist phenotype.

BACKGROUND: It remains unknown whether the hypertriglyceridemic waist (HW) phenotype, an appropriate screening tool in adults, can also be used to screen for metabolic abnormalities in adolescents. OBJECTIVE: We aimed to evaluate metabolic risk factors identified by the HW phenotype in adolescents. DESIGN: Anthropometric and biochemical measurements were assessed in a population-based cross-sectional study of 1413 male and 1623 female Iranian adolescents aged 10-19 y. The HW phenotype was defined as serum triacylglycerol concentrations > or = 110 mg/dL and concurrent waist circumference > or = 90th percentile for age and sex. Elevated fasting glucose (> or = 110 mg/dL), high LDL (> or = 130 mg/dL) and low HDL (< or = 40 mg/dL) cholesterol, hypercholesterolemia (total cholesterol > or = 200 mg/dL), and hypertension (systolic or diastolic blood pressure > or = 95th percentile for age, sex, and height) were considered as risk factors. RESULTS: Adolescents with the HW phenotype had significantly higher prevalences of all metabolic risk factors except elevated fasting glucose than did those without the HW phenotype. After control for potential confounding variables, adolescents with the HW phenotype were significantly more likely to have high LDL cholesterol (odds ratio: 1.8; 95% CI: 1.3, 2.7), low HDL cholesterol (1.6; 1.3, 2.0), hypercholesterolemia (2.9; 2.0, 4.2), and > or = 1 (1.4; 1.1, 1.7) and > or = 2 (2.2; 1.6, 3.0) risk factors than were those without the HW phenotype. The HW phenotype had a significantly higher percentage of correct prediction of metabolic abnormalities than did overweight, elevated triacylglycerol concentration, or enlarged waist circumference. CONCLUSION: This study shows a clustering of metabolic abnormalities in adolescents with the HW phenotype and suggests this phenotype as a simple marker for identifying adolescents at risk of metabolic syndrome and other metabolic abnormalities.

Adolescent↗
PubMed2006

Hepatic lipase C-514T polymorphism and its association with high-density lipoprotein cholesterol level in Tehran.

BACKGROUND: The study was conducted to obtain the frequency of the hepatic lipase C-514T polymorphism and evaluate its relation with serum HDL cholesterol levels in Tehran. METHODS: A segment of the gene mentioned was amplified by polymerase chain reaction in 545 people and the restriction fragment length polymorphism revealed. RESULTS: The T allele frequency was 0.154. No significant relationship between HDL cholesterol levels and C-514T polymorphism was found even after adjusting for age, body mass index and blood pressure. CONCLUSION: The frequency of the polymorphism is similar to other Caucasian populations and no significant relationship exists between the non-CC genotype of the gene and a higher serum HDL cholesterol concentration.

Adult↗
PubMed2006

Association of total cholesterol versus other serum lipid parameters with the short-term prediction of cardiovascular outcomes: Tehran Lipid and Glucose Study.

OBJECTIVE: The aim of this study was to evaluate and compare the role of lipid markers including total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol with lipid indices (total/HDL cholesterol, LDL-cholesterol/HDL-cholesterol and non-HDL-cholesterol) as predictors of cardiovascular outcomes in adults over 30 years. RESEARCH DESIGN AND METHOD: In a nested case-control study, 207 cardiovascular events among participants of the Tehran Lipid and Glucose Study (TLGS) were documented during 3 years of follow-up. Those cases that were free of cardiovascular disease at baseline (132 subjects) were matched to 264 controls for age and sex. In all subjects, demographic and clinical data including blood pressure and anthropometric measurements as well as serum lipids, fasting and 2-h plasma glucose were obtained from the database of the TLGS. We estimated the relative risk for each lipid parameter in a multiple stepwise regression model after adjustment for family history of premature coronary heart disease, smoking, systolic and diastolic blood pressure, fasting and 2-h plasma glucose and waist-to-hip ratio. RESULTS: The relative risks associated with an increase of approximately 1 SD of independent lipid predictors in the multivariate model were as follows: total cholesterol, 1.6 (1.2-2.1), SD=1.3 mmol/l; LDL-cholesterol 1.5 (1.1-2.0), SD=1 mmol/l; non-HDL-cholesterol 1.6 (1.2-2.1), SD=1.2 mmol/l and cholesterol/HDL-cholesterol 1.5 (1.1-2.0), SD=1.8. Comparison of these four independent variables with receiver-operating characteristic curve analysis showed no significant difference in their predictive power for cardiovascular outcome. There was no association between HDL-cholesterol, triglyceride and LDL/HDL cholesterol and cardiovascular disease outcomes in multivariate analysis. CONCLUSION: It seems that for short-term prediction of cardiovascular disease outcome, serum total cholesterol is the preferred lipid parameter to measure in the Iranian population.

Adult↗
PubMed2006

The safety and efficacy of antithyroid drugs.

Thionamides, selective inhibitors of thyroid peroxidase-mediated iodination by tyrosine residues in thyroglobulin, have been effectively used in the treatment of hyperthyroidism. The choices for initial treatment of patients with Graves' disease differ in various countries, and many physicians around the world prefer to administer thionamide drugs as the first choice of treatment for patients with hyperthyroidism. Although some thyroidologists more often consider radioiodine to be the treatment of choice because of its safety and ease of administration, thionamides remain the mainstay of treatment in thyrotoxic children and adolescents and in hyperthyroid women during pregnancy, postpartum period and lactation. A recent study with continuous thionamide treatment for patients with Graves' disease shows its efficacy, safety and cost-benefit properties. Further studies of the effectiveness of continuous thionamide therapy in patients with thyrotoxicosis need to be designed and implemented to determine indications for such therapy in children, adolescents and adults with diffuse toxic goiter, in particular, in those who have had recurrence of hyperthyroidism after discontinuation of one complete course of treatment.

Adolescent↗
PubMed2006

Diet composition and body mass index in Tehranian adults.

Human studies investigating the relationship between macronutrients intake and obesity, have failed to achieve consistent findings. This study was undertaken to assess the relationship between macronutrients intake and body mass index in a group of Tehranians. From 15,005 participants of the Tehran Lipid and Glucose Study, 1290 subjects aged over 10 years (565 males and 725 females) were selected randomly for dietary survey. Anthropometric indices were measured according to standard protocols and BMI was calculated. Dietary data were collected by trained interviewers using two non-consecutive 24-hour dietary recalls. Data on smoking habits, educational level and physical activity were compiled. Under- and over-reporting of energy intake were defined as EI: BMR < 1.35 and > or = 2.4, respectively. Calorie-adjusted amounts of macronutrients were calculated by the residual method, following which energy intakes from all calorie-adjusted macronutrients were simultaneously included in the multiple regression models controlling for age, physical activity, educational level and smoking and mutual effects of macronutrients. Total energy intake was not included to avoid collinearity. BMI increased with age in either gender. Controlling for confounding variables, energy intake from fat was positively associated with BMI in males in the 10-18, 19-24, 25-50 and 51+ year age categories (beta = 0.06, 0.13, 0.33, 0.48, P<0.05 for all, respectively) and females in the 19-24, 25-50 and 51+ age categories (beta = 0.17, 0.43, 0.52, P<0.05 for all, respectively). This relationship remained after excluding misreporters (beta = 0.06, 0.15, 0.36, 0.50 for males and beta = 0.21, 0.46, 0.54 for females in the corresponding age categories, respectively). The correlation of fat intake to BMI was not significant in younger females (10-18 year). No association was seen between energy intake from protein and carbohydrate with BMI in subjects before and after exclusion of misreporters. In conclusion, energy from fat was found to be independently and positively associated with obesity in adults. No other association was observed between energy from protein and carbohydrate with BMI.

Adolescent↗
PubMed2006

Under-reporting of energy intake affects estimates of nutrient intakes.

Under-reporting of energy intake is a common problem in nutritional epidemiological studies. The aim of the present study was to determine the effect of under-reporting of energy intake on the estimates of nutrient intakes. In this cross-sectional study, 901 subjects aged >16 y were randomly selected from participants of the Tehran Lipid and Glucose Study. Dietary intake was assessed by means of two 24-hour dietary recalls. Basal metabolic rate (BMR) was determined according to age, sex and weight. The ratio of energy intake (EI) to BMR was calculated. Under-reporting of energy intake was defined as EI:BMR< 1.35 and normal-reporting of dietary intake as EI:BMR = 1.35-2.39. To obtain energy-adjusted amounts of macro- and micronutrients, the residual method was used. Under-reporting of energy intake was revealed in 31% of the subjects and was more common among females (40%) than males (19%, P <0.01). The mean age of females who under-reported was significantly lower than the normal-reporting females (32 +/- 13 vs. 35 +/- 14 y, P <0.05); however, the age difference between the two groups was not significant in men. Under-reporters had higher BMIs compared to normal-reporters in both genders. The absolute intakes of macro- and micronutrients (except for B12 in females and B6 and zinc in both genders) were lower in under-reporters, but following adjustment, no significant differences were seen. The results have revealed that under-reporting of energy intake affects the estimates of nutrient intakes; thus in studies aimed at determining the association between a certain chronic disease and a nutrient intake, we suggest adjustments be made for energy intake.

Adolescent↗
PubMed2005

Larger hip circumference independently contributed to reduced metabolic risks in Tehranian adult women.

BACKGROUND: It has been suggested that health professionals may discard measurement of hip circumference from public health screening efforts. Before discarding the hip circumference in epidemiological surveys, it is important to consider whether any important information is likely to be lost. OBJECTIVE: To evaluate the relationship between hip circumference and metabolic risk factors in an urban adult population of Tehranian women. DESIGN: In this population-based cross-sectional study, a representative sample of 5720 women aged 18-74 years, were included. Demographic data was collected; anthropometric indices and blood pressure were measured according to standard protocol. Hypertension was defined based on Joint National Committee VI (JNC VI). Biochemical analysis was conducted on fasting blood samples. Diabetes was defined as fasting plasma glucose (FPG) > or =126 mg/dl or 2-h plasma glucose (2hPG) > or =200 mg/dl. Lipid disorders and components of metabolic syndrome were considered based on Adult Treatment Panel III (ATP III). RESULTS: Mean age of women was 39.9+/-14.6 years. Mean body mass index, waist-to-hip ratio, waist and hip circumferences for subjects were 27.1+/-5.1 kg/m2, 0.83+/-0.08, 86.5+/-13.1 cm and 103.5+/-9.8 cm, respectively. Higher hip circumference was associated with lower levels of serum total- and LDL-cholesterol, serum triglyceride, fasting plasma glucose, 2-h plasma glucose, systolic and diastolic blood pressure. Subjects in the top quintile of hip circumference had higher values of serum HDL-cholesterol concentration compared to those in the lower category. After adjustment for potential confounding variables and anthropometric measures associated with higher hip circumference, a significant decreasing trend was observed for odds of having high LDL-cholesterol (odds ratios among quintiles: 1.00, 0.98, 0.97, 0.95, 0.84, respectively, P for trend=0.04), diabetes (1.00, 0.68, 0.58, 0.45, 0.42, P for trend=0.01), hypertension (1.00, 0.96, 0.82, 0.78, 0.70, P for trend 0.02), low serum HDL-cholesterol (1.00, 1.03, 0.86, 0.82, 0.56, P for trend=0.04), elevated blood pressure (1.00, 0.99, 0.82, 0.70, 0.61, P for trend=0.01) and abnormal glucose homeostasis (1.00, 0.69, 0.66, 0.54, 0.48, P for trend=0.01) among hip circumference quintile categories. Individuals in the upper category of hip circumference had lower odds of having hypercholestrolemia (0.86 vs. 1.00) and high serum triglyceride levels (0.74 vs. 1.00) compared to those in the lowest category. CONCLUSION: Hip circumference is independently and inversely associated with metabolic risk factors. This study underscores the importance of continuing to measure hip circumference in epidemiologic surveys in Tehranian adult women.

Adolescent↗
PubMed2005

Is there an independent association between waist-to-hip ratio and cardiovascular risk factors in overweight and obese women?

BACKGROUND: This study was conducted to evaluate the relationship between waist-to-hip ratio (WHR) and cardiovascular risk factors in overweight and obese women and to determine a point of WHR above which the chances of having cardiovascular risk factors increased. METHODS: In this cross-sectional study, 2892 pre- and postmenopausal women aged 20-78 years with body mass index (BMI) > or = 25 selected from among 5791 women of the Tehran Lipid and Glucose Study (TLGS) population (n = 15,005), by multistage cluster random sampling method, were included. Anthropometric indices were measured and BMI and WHR were calculated. Blood pressure was evaluated according to standard protocols. Biochemical indices were measured in the fasting state. Subjects were placed into the high-risk categories for cardiovascular disease on the basis of population-defined norms. Women were divided into quartiles based on their WHR: quartile 1: < 0.78, quartile 2: 0.78- < 0.83, quartile 3: 0.83- < 0.88, quartile 4: > or = 0.88 for premenopausal women, and quartile 1: < 0.84, quartile 2: 0.84- < 0.9, quartile 3: 0.9- < 0.94 and quartile 4: > or = 0.94 for postmenopausal women. RESULTS: A lower proportion of pre- and postmenopausal women with BMI > or = 35 were in quartile 1 and a higher proportion in quartile 4. A significant increasing trend was observed for odds ratio of having low HDL-C, high triglyceride, high total-/HDL-cholesterol and high fasting blood sugar (FBS) with increasing WHR. Controlling for BMI and simultaneously adjusting for confounding variables had no effect on this trend. Although no significant increasing trends were seen for having high total cholesterol, LDL-cholesterol, systolic and diastolic blood pressure with quartiles of WHR in both pre- and postmenopausal women, subjects with higher quartiles of WHR still had higher chances for having high total cholesterol. In the case of postmenopausal women having of higher odds for high LDL-cholesterol and high systolic blood pressure in the fourth quartile of WHR should also be added to the high total cholesterol. CONCLUSION: The results showed that in overweight and obese women, chances of having cardiovascular risk factors increased with WHR > or = 0.78 for premenopausal and with WHR > or = 0.84 for postmenopausal women.

Adult↗
PubMed2005

Trends in overweight, obesity and central fat accumulation among Tehranian adults between 1998-1999 and 2001-2002: Tehran lipid and glucose study.

AIMS: Recent estimates show the prevalence of obesity to be increasing at alarming rates. This study was conducted to examine trends of prevalence in overweight, obesity and central fat accumulation among Tehranian adults between 1998 and 2002. METHODS: Height and weight of 2,102 adults, aged 20-80 years, participants of the Tehran Lipid and Glucose Study, were measured in 1998-1999 and remeasured in 2001-2002, after 3 years. Criteria used to state prevalence of overweight and obesity were body mass index (BMI) 25-29.9 and > or =30, respectively. Central fat accumulation was defined as waist-hip ratio (WHR) > or =0.8 in women and > or =0.9 in men. Individuals were divided into 10-year groups and the prevalence of obesity was compared according to sex and age. RESULTS: In 1998-1999 and 2001-2002, mean BMI was 26.1 +/- 4.1 and 26.7 +/- 4.1 kg/m(2) in men (p < 0.001) and 27.8 +/- 4.9 and 28.7 +/- 5.9 kg/m(2) in women (p < 0.001), respectively. Mean WHR in women was 0.84 +/- 0.08 in 1998-1999 and 0.88 +/- 0.08 in 2001-2002 (p < 0.001). The prevalence of overweight in men was 42.5 and 46% and 40 and 39.5% in women in the two mentioned periods. The prevalence of obesity was 32.7 and 40.3% in men and 16.5 and 20.8% in women in 1998-1999 and 2001-2002 respectively. In both sexes the fastest increasing trends in obesity and central fat accumulation were seen in the 30- to 40- and 20- to 30-year-old age groups. Comparison of the 50th percentile of BMI in all age groups showed a significant increase in 2001-2002 as compared to 1998-1999 (p < 0.01). CONCLUSION: The findings demonstrate significant rises in the prevalence of both total and central fat accumulation, calling for urgent action to educate people in lifestyle modifications.

Abdomen↗
PubMed2005

Dietary quality-adherence to the dietary guidelines in Tehranian adolescents: Tehran Lipid and Glucose Study.

The aim of this study was to determine the Healthy Eating Index (HEI) score and its relation take of nutrients and the number of servings from each food group consumed by adolescents residing in district 13 of Tehran. This study, conducted within the framework of Tehran Lipid and Glucose Study (TLGS), was a part of a dietary intake assessment carried out in 443 families, including 465 adolescents, aged 10-18 years, according to the Food Guide Pyramid and dietary guidelines on individuals residing in district 13 of Tehran. In this study, dietary intake was assessed with two-day 24-hour recalls. HEI was calculated based on nine components. The score range of each component was 0 to 10, the sum score of this index therefore being 90. The HEI score was categorized into three groups: less than 45 (poor diet), between 45-72 (needs improvement) and more than 72 (good diet). The mean score of HEI was 64.9 +/- 9.6 in boys and 64.8 +/- 9.4 in girls. The results showed that the number of servings of food groups in those with good diet was significantly higher than the two other groups (p < 0.05). In contrast the percent of saturated fat intake and cholesterol consumption in those with HEI > or = 72 was lower than the other groups (p < 0.05). The approximate number of food items consumed and the total nutrient intake by adolescents with HEI score > or = 72 was significantly higher than the others (p < 0.05). There was a significant positive correlation between the number of servings of grains group (r = 0.1), vegetables (r = 0.4), fruits (r = 0.4), dairy (r = 0.3), meat (r = 0.1), and HEI (p < 0.001). There was a significant negative correlation between fat intake (r = -0.2, p < 0.001), percent of saturated fatty acids (r = -0.2, p < 0.05), cholesterol consumption (r = -0.4, p < 0.05), and the ratio of polyunsaturated fatty acids/saturated fatty acids (P/S) in diet (r = 0.2, p < 0.05), and HEI score. Seventy-four, 23, and 3% of diets were categorized into "needs improvement", "good", and "poor", respectively. In conclusion, the diets of most Tehranian adolescents need improvement, demonstrating the need for nutrition education in this age group.

Adolescent↗