Biomedical subjects

Ferenc Brittig

Publications and source records attributed to Ferenc Brittig.

3 recordsLinked to original sources

PubMed2005

[Primary squamous cell carcinoma of the breast].

Primary squamous cell carcinoma of the breast is a rare tumor that presents an unique biologic behavior. Thus, it challenges the justification for routine axillary dissection and adjuvant therapy. Squamous cell carcinoma has several unique biologic characteristics; it is associated with a lower rate of lymph node metastasis and significant rate of distant metastasis without lymph node involvement. The diagnosis of primary squamous cell carcinoma of the breast can only be established if the metastatic tumor origin can be excluded, the tumor is not attached to the skin and no other histological type of carcinoma is detected in the course of detailed histological examination. The authors present two cases from their own experience. One of them has preexisted fine needle aspiration cytology.

Aged↗

PubMed2004

Ideal cooling process for paraffin-embedded tissues.

Back in the seventies everybody was convinced that it was no longer necessary to cool paraffinembedded tissues, because of the new advances in the production of paraffin. The reason for this assumption was the addition of plastic polymers and dimethyl sulfoxide. The quality of tissue sectioning improved because of these additives. The daily routine in the histology laboratories shows that it is impossible to produce good quality cutting without cooling. Cooling the paraffin by means of cooling plates or ice dishes creates drastic improvement; the cutting quality improves and it is much easier. Both improvements speed up the process and save time for the technicians and the physician. Long-term study indicates that not only the temperature but also the methodology of cooling and the cooling rate are playing a decisive role in the cutting quality.

Cold Temperature↗

PubMed2004

Follicular dendritic reticulum cell tumor mimicking inflammatory pseudotumor of the spleen.

In the course of a routine clinical check up of the 54 year old male a splenic well circumscribed tumor like mass of 12 cm in diameter was discovered. Splenectomy with removal of splenic hilar lymph nodes and liver wedge biopsy were performed. Four years later the patient is symptom free. In the removed spleen the tumor like lesion showed a pattern consistent with the diagnosis of inflammatory pseudotumor. However, besides lymphocytes, plasma cells, macrophages, eosinophils and myofibroblasts a high number of slightly polymorphic, frequently binucleated cells positive for CD21 and CD23 were seen. These cells which were scattered or formed smaller or larger groups and fascicles were considered to represent follicular dendritic reticulum cells (FDRCs) and the lesion a FDRC tumor. Flow cytometric DNA ploidy analysis showed a hyperdiploid cell population inside the tumor like lesion. Besides FDRC tumors of high and of intermediate malignancy the present case may represent a low grade type of moderate proliferation activity. The FDRCs of the lesion and a few smaller spindle cells were EBER positive indicative of the presence of EBV. No EBER positive cells were seen in the uninvolved spleen.

DNA, Neoplasm↗