Magnetic resonance cholangiopancreatography.
Explore the source record for details and available documents.
Bile Duct Diseases↗
Biomedical subjects
Fergus V Coakley
Publications and source records attributed to Fergus V Coakley.
Prostate cancer tumor volume: measurement with endorectal MR and MR spectroscopic imaging.
PURPOSE: To determine accuracy of magnetic resonance (MR) and three-dimensional (3D) MR spectroscopic imaging in prostate cancer tumor volume measurement. MATERIALS AND METHODS: Endorectal MR and 3D MR spectroscopic imaging were performed in 37 patients before radical prostatectomy. Two independent readers recorded peripheral zone tumor nodule location and volume. Results were analyzed with step-section histopathologic tumor localization and volume measurement as the standard. Accuracy of tumor volume measurement was assessed with the Pearson correlation coefficient. P values were calculated with a random effects model. Bland-Altman regression analysis was used to evaluate systematic bias between tumor volumes measured with MR imaging and true tumor volumes. Analyses were performed for all nodules and nodules greater than 0.50 cm(3). RESULTS: Mean volume of peripheral zone tumor nodules (n = 51) was 0.79 cm(3) (range, 0.02-3.70 cm(3)). Two readers detected 20 (65%) and 23 (74%) of 31 peripheral zone tumor nodules greater than 0.50 cm(3). For these nodules, measurements of tumor volume with MR imaging, 3D MR spectroscopic imaging, and a combination of both were all positively correlated with histopathologic volume (Pearson correlation coefficients of 0.49, 0.59, and 0.55, respectively); only measurements with 3D MR spectroscopic imaging and a combination of MR and 3D MR spectroscopic imaging demonstrated statistical significance (P <.05). Tumor volume estimation with all three methods was more accurate for higher tumor volumes. CONCLUSION: Addition of 3D MR spectroscopic imaging to MR imaging increases overall accuracy of prostate cancer tumor volume measurement, although measurement variability limits consistent quantitative tumor volume estimation, particularly for small tumors.
Adult↗
Peritoneal metastases: detection with spiral CT in patients with ovarian cancer.
PURPOSE: To determine the accuracy of spiral computed tomography (CT) in the depiction of peritoneal metastases by using surgical findings in patients with ovarian cancer as the standard of reference. MATERIALS AND METHODS: Three independent readers reviewed the preoperative CT scans obtained in 64 patients who underwent primary surgery for ovarian cancer. Readers rated the likelihood of peritoneal metastases on a five-point scale and recorded the presence or absence of ascites, parietal peritoneal thickening or enhancement, and small-bowel wall thickening or distortion. Peritoneal metastases were identified as nodular, plaquelike, or infiltrative soft-tissue lesions in the peritoneal fat or on the peritoneal surface. Area under the receiver operating characteristic curve was calculated for each reader. Interreader agreement was evaluated with the kappa statistic. Descriptive statistical data were determined with dichotomized ratings (1-3 = absent; 4-5 = present). RESULTS: Areas under the receiver operating characteristic curves for the three readers were 0.95, 0.93, and 0.89. Paired kappa values ranged from 0.75 to 0.91. Reader sensitivity for metastases 1 cm or smaller in maximum diameter (25%-50%) was significantly (P <.05) lower than overall sensitivity (85%-93%). Ascites, parietal peritoneal thickening or enhancement, and small-bowel wall thickening or distortion demonstrated positive predictive values of 72%-93%, with kappa values of 0.12-0.80. CONCLUSION: Spiral CT is accurate in the depiction of peritoneal metastases from ovarian cancer, although sensitivity is reduced in patients with tumor implants 1 cm or smaller. Ancillary signs of peritoneal malignancy are limited by low interobserver agreement.
Adult↗
Case 51: paroxysmal nocturnal hemoglobinuria with thrombotic Budd-Chiari syndrome and renal cortical hemosiderin.
Explore the source record for details and available documents.
Adult↗
Mesenteric adenopathy in patients with prostate cancer: frequency and etiology.
OBJECTIVE: This study was undertaken to determine the frequency and etiology of mesenteric adenopathy revealed at initial-staging CT in patients with prostate cancer. CONCLUSION: Mesenteric adenopathy is a rare finding at initial-staging CT in patients with prostate cancer and is more often due to coexistent lymphoma than to metastatic disease, particularly in the absence of associated pelvic adenopathy and a markedly elevated serum prostate-specific antigen level. Appropriate radiologic interpretation of the finding prevents overstaging of prostate cancer.
Aged↗
Frequency and etiology of midesophageal diverticula at barium esophagography.
Midesophageal diverticula were identified at 8 of 218 (3.6%) esophagrams performed over a 3-year period in adult patients with no prior history of gastroesophageal surgery. All eight patients received a final diagnosis of esophageal dysmotility with secondary pulsion diverticula, and seven of eight (88%) patients had abnormal peristalsis noted during the esophagram. We conclude that most, if not all, midesophageal diverticula are pulsion in etiology, and the detection of a midesophageal diverticulum should prompt a careful search for underlying dysmotility.
Adult↗
Frequency of hepatic contour abnormalities and signs of portal hypertension at CT in patients receiving chemotherapy for breast cancer metastatic to the liver.
PURPOSE: This study aimed to determine the frequency of hepatic contour abnormalities and signs of portal hypertension at serial CT in patients receiving chemotherapy for breast cancer metastatic to the liver. MATERIALS AND METHODS: We retrospectively identified 91 women with breast cancer metastatic to the liver who received chemotherapy and underwent serial CT at our institution between 1998 and 2002. Two readers independently categorized hepatic contour abnormalities on the final CT examination as none, limited retraction, widespread retraction, or diffuse nodularity. Readers also recorded the development of hepatic atrophy or enlargement, ascites, portosystemic collateral veins, and splenomegaly. Interpretative discrepancies were resolved by consensus. Portal hypertension was defined as the presence of at least two of the following CT signs: simple ascites, portosystemic collateral veins, and splenomegaly. RESULTS: After a median follow-up interval of 15 months (range, 1-46), hepatic contour abnormalities were seen in 68 of 91 patients (75%) and consisted of limited retraction (n = 42), widespread retraction (n = 10), or diffuse nodularity (n = 16). Portal hypertension was found in 1 of 23 patients without contour abnormalities, in 1 of 42 patients with limited retraction, in none of 10 patients with widespread retraction, and in 6 of 16 patients with diffuse nodularity (P < .01). CONCLUSION: Hepatic contour abnormalities commonly develop at serial CT in patients undergoing chemotherapy for breast cancer metastatic to the liver and may be accompanied by signs of portal hypertension; the latter are particularly, but not exclusively, associated with the development of diffuse hepatic nodularity.
Adult↗
CT and MRI of hepatic pseudotumor in long-standing biliary atresia.
Two patients who developed a hepatic pseudotumor in long-standing biliary atresia treated by hepatoportoenterostomy are presented. Both masses were detected during routine imaging surveillance prior to liver transplantation. The CT, MR, and pathologic appearances are described. Accurate radiologic identification of this entity is important for appropriate clinical management.
Adolescent↗
CT and MRI of retroperitoneal edema associated with large uterine leiomyomas.
Two cases of retroperitoneal edema surrounding the left ovarian vein that were associated with large uterine leiomyoma are presented. This finding was not associated with any specific lateralizing symptoms or with any evidence of malignancy. One patient underwent hysterectomy with surgical exploration of the retroperitoneum that confirmed the absence of malignancy. The CT and MR findings in this entity are described and possible etiological mechanisms discussed. Recognition that large leiomyoma can be associated with benign retroperitoneal edema may help avoid inappropriate management.
Adult↗
Breath-hold magnetic resonance cholangiopancreatography in the evaluation of malignant pancreaticobiliary obstruction.
OBJECTIVE: This study was designed to determine the effectiveness of magnetic resonance cholangiopancreatography (MRCP) using a breath-hold single-shot fast spin echo (SSFSE) technique in imaging patients with malignant biliary and/or pancreatic duct obstruction. METHODS: One hundred thirty-one breath-hold MRCP studies in patients with malignant pancreatic and/or biliary obstruction were evaluated. Pathologic diagnoses included pancreatic cancer, biliary malignancy, gallbladder carcinoma, hepatic neoplasms, malignant lymphadenopathy, and ampullary carcinoma. Two observers independently reviewed the images in a blinded fashion to assess the level of obstruction and the site of underlying tumor. RESULTS: The level of obstruction was correctly identified in 104 of 131 cases (79%) by observer 1 and in 107 of 131 cases (82%) by observer 2. The site of underlying tumor was correctly identified in 113 of 131 cases (86%) by observer 1 and in 110 of 131 cases (84%) by observer 2. CONCLUSION: Magnetic resonance cholangiopancreatography utilizing the SSFSE technique can accurately assess the level of obstruction and the site of underlying tumor in patients with malignant pancreaticobiliary obstruction, without the risks of cholangiography. This MRCP technique allows for visualization of intra- and extraductal anatomy and pathology.
Bile Duct Neoplasms↗
Appearance and distinguishing features of retroperitoneal calcifications at computed tomography.
OBJECTIVES: To describe the appearance of retroperitoneal calcifications seen at computed tomography (CT) and to investigate which CT features distinguish benign from malignant retroperitoneal calcifications. METHODS: We identified 25 patients with retroperitoneal calcifications by retrospective review of 39,931 abdominopelvic CT scans. Etiology of retroperitoneal calcifications was determined by examination of medical and histopathological records. By consensus, 2 abdominal radiologists recorded calcification number (solitary or multiple), location (suprarenal or infrarenal), morphology (globular or nonglobular), and the presence of soft-tissue components. The association between CT findings and etiology was assessed using the Fisher exact test. RESULTS: Retroperitoneal calcifications were malignant in 15 patients and benign in 10. Solitary calcifications were seen more commonly in patients with benign disease (6 of 10 vs. 1 of 15, P < 0.01). Suprarenal calcifications were seen only in patients with malignancy (13 of 15 patients, P < 0.01). Nonglobular calcifications were seen only in patients with benign disease (6 of 10, P < 0.01). Soft-tissue components were seen more commonly in patients with malignancy (14 of 15 vs. 4 of 10; P < 0.01). CONCLUSIONS: Retroperitoneal calcifications are rarely seen at CT and may be benign or malignant in etiology. Solitary or nonglobular retroperitoneal calcifications are likely to be benign while calcifications that are multiple, globular, suprarenal, or associated with noncalcified soft-tissue components are likely to be malignant.
Adult↗
Computed tomography and magnetic resonance imaging of inferior vena caval thrombus associated with metastasis to the kidney.
The computed tomography and magnetic resonance imaging findings in 2 cases of inferior vena caval thrombus associated with metastases to the kidney are presented. In both cases, the radiologic findings were suggestive of renal cell carcinoma. Recognition that metastases to the kidney can be associated with inferior vena caval thrombus broadens the differential diagnosis in a patient with a renal mass, an inferior vena caval filling defect, and a known primary malignancy, potentially altering the diagnostic approach.
Adenocarcinoma↗
Computed tomography of corpus luteal cysts.
OBJECTIVE: To describe the computed tomography (CT) features of corpus luteal cysts. METHODS: We retrospectively identified 10 patients with a diagnosis of corpus luteal cysts established by ultrasound who had also undergone contemporaneous CT. A single attending radiologist, without knowledge of other clinical or radiologic findings, recorded the morphologic features of the cysts based on the CT images. RESULTS: The corpus luteal cyst seen at sonography was visible at CT in all 10 patients. All cysts were unilocular, with a mean density of 25 HU (range, 12 to 45). The mean maximum axial cyst diameter was 2.2 cm (range, 1.4 to 2.9). The mean cyst wall thickness was 3 mm (range, 2 to 4). All cyst walls were crenulated. Cyst wall enhancement was hyperdense in 6 cases, isodense in 3 cases, and hypodense in 1 case. Free fluid was seen in 9 of 10 patients. CONCLUSIONS: At CT, corpus luteal cysts are typically less than 3 cm in diameter and are characterized by a thick, crenulated, or hyperdense wall. Recognition of these CT findings should prevent misinterpretation or inappropriate management.
Adolescent↗
Intrahepatic portal-to-portal venous shunts in cirrhosis: a potential mimic of hepatocellular carcinoma.
Two intrahepatic portal-to-portal venous shunts demonstrated at computed tomography (CT) and ultrasound in a 40-year-old woman with cirrhosis are described. The shunts appeared as hypervascular hepatic foci on CT, simulating multifocal hepatocellular carcinoma. Follow-up multiphase CT with multiplanar reformation and Doppler ultrasound confirmed the correct diagnosis. Recognition of intrahepatic portal-to-portal venous shunts as a rare mimic of hepatocellular carcinoma in cirrhosis should prevent misinterpretation or inappropriate management.
Adult↗
Atypical cases of gallstone ileus evaluated with multidetector computed tomography.
OBJECTIVE: To describe the multidetector computed tomography (CT) findings in 3 patients with atypical gallstone ileus. METHODS: We retrospectively evaluated computed radiography and CT images from three cases of surgically proven gallstone ileus. Two radiologists evaluated by consensus all images for the presence of ectopic gallstone, small bowel obstruction, intrahepatic pneumobilia, cholecystic pneumobilia. One author recorded whether diagnosis of gallstone ileus was made prospectively on radiologic reports and correlated findings to pathology. RESULTS: All cases of gallstone ileus were atypical in that one patient had porcelain gallbladder, one had recurrent pyogenic cholangitis, and one was only 35 years of age. Prospective clinical diagnosis of gallstone ileus was made in only 1 patient at computed radiography and all 3 patients at CT. Retrospectively, small bowel obstruction and cholecystic pneumobilia were identified retrospectively in all 3 patients at both computed radiography and MDCT, and an ectopic gallstone, intrahepatic pneumobilia, and choledochoduodenal fistula was seen in 2, 1, and 0 patients at computed radiography and 3, 2, and 3 patients at CT respectively. CONCLUSION: Multidetector CT is an accurate means to diagnose gallstone ileus, even in patients with atypical features. In particular, multidetector CT is useful for identifying the ectopic gallstone at the transition point between dilated and decompressed bowel.
Adult↗
Magnetic resonance imaging of ovarian cancer arising in endometriomas.
The magnetic resonance imaging (MRI) findings in 2 cases of ovarian cancer arising in an endometrioma are presented. In both cases, the cancer was evident as an enhancing mass within a blood-filled adnexal cyst. The MRI findings of an enhancing mass within a blood-filled adnexal cyst should prompt consideration of ovarian cancer arising in an endometrioma, facilitating recognition of a superimposed malignancy and potentially allowing for earlier and more efficacious treatment.
Adenocarcinoma, Clear Cell↗
Growth rate of hepatocellular carcinoma: evaluation with serial computed tomography or magnetic resonance imaging.
OBJECTIVE: To evaluate the growth rate of untreated hepatocellular carcinoma (HCC) by calculating tumor volume doubling time (TVDT) on serial computed tomography (CT) or magnetic resonance imaging (MRI) and to predict TVDT based on initial tumor size. METHODS: Sixteen untreated HCCs in 11 patients with cirrhosis who underwent serial CT or MRI at our institution were retrospectively identified. Two independent readers recorded bidimensional measurements for all tumors, which were used to determine tumor volume (TV). Growth rate was expressed as TVDT. A mathematic model was used to predict TVDT based on baseline tumor size. RESULTS: Mean baseline and follow-up TVs were 10.5 cm3 (range: 0.7-243.6 cm3) and 22.0 cm3 (range: 2.5-870.8 cm3), respectively. Mean duration of follow-up was 176 days (range: 76-472 days). Mean TVDT was 127 days (95% confidence interval: 80, 203; range: 17.5-541.4 days). Expected TVDT could be expressed as TVDT = 114 x (baseline volume)0.14 (P < 0.002). CONCLUSION: The results of this study suggest a preferred interval follow-up of approximately 4.5 months (127 days) for HCC screening. Small HCCs show a tendency toward faster growth and may require shorter follow-up to demonstrate progression.
Adult↗
Magnetic resonance imaging of hepatocellular carcinoma mimicking focal nodular hyperplasia: a potential pitfall in patients with cirrhosis?
The magnetic resonance imaging findings in 2 cases of pathologically proven hepatocellular carcinoma that mimicked focal nodular hyperplasia are presented. Both cases were found in patients with cirrhosis, a condition in which focal nodular hyperplasia is unlikely to occur. Recognition that hepatocellular carcinoma may mimic focal nodular hyperplasia in patients with cirrhosis may prevent misdiagnosis and allow for earlier intervention.
Aged↗