Biomedical subjects

Fida Hussain

Publications and source records attributed to Fida Hussain.

6 recordsLinked to original sources

PubMed2006

Interactions between sparfloxacin and antacids - dissolution and adsorption studies.

Sparfloxacin is a broad-spectrum oral fluoroquinolone antimicrobial agent with a long elimination half-life, extensively used against both Gram-positive as well as Gram-negative microorganism. Concurrent administration of antacids and sparfloxacin decreases the gastrointestinal absorption of sparfloxacin and therapeutic failure may result. The present study was designed to evaluate the influence of some antacids on the availability of sparfloxacin. The release of sparfloxacin from tablets in the presence of antacids like sodium bicarbonate, calcium hydroxide, calcium carbonate, aluminum hydroxide, magnesium hydroxide, magnesium carbonate, magnesium trisilicate and magaldrate has been studied on BP 2003 dissolution test apparatus. These studies were carried out in simulated gastric and intestinal juices for three hours at 37 degrees C. The results confirmed that the dissolution rate of tablets was markedly retarded in the presence all of antacids studied, whereas magaldrate and calcium carbonate exhibited relatively higher adsorption capacities in simulated gastric juice and magnesium trisilicate and calcium hydroxide in simulated intestinal juice.

Adsorption↗

PubMed2006

Fabrication of nanoparticles within polymeric pores for controlled release of drug.

Nanotechnology, a multidisciplinary scientific undertaking, involves creation and utilization of materials, devices or systems on the nanometer scale. The field has enabled the development of an amazing variety of methods for fabricating nanoparticles in recent years. The technology is expected to create innovations and play a critical role in the field of bio-pharmaceuticals especially in controlled release of drug delivery. Sol-gel technique is one of the most widely used techniques to fabricate porous nanoparticles within the polymer. Such nanoparticles have also applications in vascular drug delivery and release, site-specific targeting (passive as well as active targeting), as well as transfusion medicine. This article concentrates mainly on fabrication of porous nanoparticles, its characterisation and its use for controlled release of drug. It also encompasses the strategies that have been used to translate and fabricate a wide range of particulate carriers e.g., nanospheres, liposomes, micelles, oil-in-water emulsions, with prolonged circulation and/or target specificity. With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers. we have also critically reviewed and assessed the fate and activity of biodegradable/bio-erodable polymeric drug delivery vehicles because the uniformity in degradation of these polymers is questionable.

Delayed-Action Preparations↗

PubMed2006

Degradation studies of azithromycin and its spectrophotometric determination in pharmaceutical dosage forms.

A simple, accurate and rapid spectrophotometric method for the estimation of azithromycin has been developed by the acidic hydrolysis of the drug with sulfuric acid and monitoring the absorbance at 482 nm. All variables affecting the reaction conditions such as sulfuric acid concentration, heating time, temperature and dilution solvents were carefully studied. Analytical parameters such as stability, selectivity, accuracy and precision have been established for the method and evaluated statistically to assess the application of the method. The method was applied successfully for the assay of azithromycin dihydrate in pure and pharmaceutical dosage forms as tablets, capsules and suspensions. The method was found to have the advantages for simplicity, stability, sensitivity, reproducibility and accuracy for using as an alternate to the existing non-spectrophotometric methods for the routine analysis of the drug in pharmaceutical formulations and also in pharmaceutical investigations involving azithromycin dihydrate.

Anti-Bacterial Agents↗

PubMed2006

Spectrophotometric method for quantitative determination of iron (III) from iron polymaltose complex in pharmaceutical formulations.

A visible spectrophotometric method has been developed for the quantification of iron (III) from iron polymaltose complex in pure and in pharmaceutical preparations. The method is based on hydrolysis of iron polymaltose complex under acidic conditions and the formation of red colored chromogen with ammonium thiocyanate, which showed absorption peak at 471 nm. This absorption wavelength can be used for the determination of iron (III) from iron polymaltose complex. The limit of detection of iron polymaltose complex at 476 nm was 6.207 ng mL(-1). The calibration was linear in the range of 19.8-22.2 microg mL(-1). Analytical parameters such as stability, selectivity, accuracy and precision have been established for the method in HAEMOTYL syrup and evaluated statistically to assess the application of the method. The method was validated under the ICH and USP guidelines and found to comprise the advantages for simplicity, stability, sensitivity, reproducibility and accuracy for using as a method for the routine analysis of the drug in pharmaceutical formulations and in pharmaceutical investigations involving iron polymaltose complex.

Chemistry, Pharmaceutical↗

PubMed2005

Interactions between ciprofloxacin and antacids--dissolution and adsorption studies.

Ciprofloxacin is a fluorinated quinolone antibacterial agent extensively used against both Gram-positive and Gram-negative microorganisms. In certain polytherapy programs, ciprofloxacin can be administered with some antacids that could modify its dissolution rate and reduce its absorption leading to therapeutic failure. The aim of this study was to evaluate the influence of some antacids on the availability of ciprofloxacin. The release of ciprofloxacin from tablets in the presence of antacids, such as sodium bicarbonate, calcium hydroxide, calcium carbonate, aluminum hydroxide, magnesium hydroxide, magnesium carbonate, magnesium trisilicate and magaldrate was studied on BP 2002 dissolution test apparatus. These studies were carried out in simulated gastric and intestinal juices for 3 hours at 37 degrees C. The results confirmed that the dissolution rate of tablets was markedly retarded in the presence of all the antacids studied. Magaldrate and calcium carbonate in simulated gastric juice exhibited relatively higher adsorption capacities, as did magnesium trisilicate and calcium hydroxide in simulated intestinal juice.

Adsorption↗

PubMed2005

In vitro monitoring of ciprofloxacin antacids interactions by UV & HPLC.

Ciprofloxacin or 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl]-3-quinoline carboxylic acid is a fluorinated quinolone antibacterial agent extensively used worldwide. There are number of drug interactions reported for this antibacterial agent. In present studies, in vitro release of ciprofloxacin hydrochloride in presence of various antacids like sodium bicarbonate, calcium hydroxide, calcium carbonate, aluminum hydroxide, magnesium hydroxide, magnesium carbonate, magnesium trisilicate and magaldrate has been studied on BP 2002 dissolution test apparatus. Drug in each case was analyzed either by measuring the absorbance of aliquots at 278 and 316 nm on a UV/VIS spectrophotometer, or by reversed-phase high-performance liquid chromatographic (RP-HPLC) method. These studies were carried out in simulated gastric and intestinal juices for three hours at 37 degrees C. The availability of ciprofloxacin was found to be markedly retarded in presence of all the antacids studied.

Adsorption↗