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Figen Oztürk

Publications and source records attributed to Figen Oztürk.

5 recordsLinked to original sources
PubMed2006

Two-dimensional agnor evaluation as a prognostic variable in urinary bladder carcinoma: a different approach via total agnor area/nucleus area per cell.

Traditional criterions are not sufficient to predict accurately the recurrence of transitional cell carcinoma of the urinary bladder. Therefore, we aimed to evaluate the AgNORs via total AgNOR area/nucleus area (TAA/NA) for each cell as a prognostic parameter, in TCC of urinary bladder. Tumor tissues of 20 consecutive cases of male bladder cancer patients were divided into two groups as middle differentiated (LG) and high grade (HG). The extra-tumoral tissue (ETT) samples of 10 males served as control group. A second control group (HC) consisted of five healthy and normal bladder tissue samples. The 3 microm of sections from each paraffin embedded tumoral, extra-tumoral and normal tissue samples served as patient and control groups. After deparaffinization and rehydratation steps, silver (AgNO(3)) staining of nucleolar organizer regions-associated proteins (AgNORs) was performed. Instead of Giemsa stain, we used Hematoxylin for contra staining. The images of the 100 analyzable nuclei from each tissue sample, transferred by means of a video camera and video capture card from microscope and recorded onto a computer. Software was prepared in Delphi language for analysis. Mean (E+02) TAA/NA values of HC, ETT, LG and HG groups were 6.97+2.80, 5.70+1.82, 7.80+3.22 and 9.24+3.88, respectively. Statistical comparisons have shown significant differences between all groups. In conclusion, mean TAA/NA per cell has a potential to be a prognostic parameter. Therefore, further evaluation of big patient series will be useful.

Antigens, Nuclear↗
PubMed2003

The role of infection and free oxygen radical damage in reflux nephropathy: an experimental study.

PURPOSE: We compared the effects of sterile and infected urine on reflux nephropathy in rabbits with experimental vesicoureteral reflux. MATERIALS AND METHODS: We used 2-month-old male New Zealand rabbits in this study. Group 1 (5 rabbits) served as the control, group 2 (7) was the vesicoureteral reflux plus sterile urine group and group 3 (8) was the reflux plus infected urine group. Cystography and 99mTc-dimercapto-succinic acid renal scintigraphy were performed before the reflux procedure. To create unilateral vesicoureteral reflux the roof of the right intravesical ureter was incised. Escherichia coli suspension (2 ml.), 105 E. coli in 1 ml.) was introduced into the bladder in addition to the reflux procedure in group 3. Right vesicoureteral reflux was confirmed by cystography 2 weeks after reflux. Dimercapto-succinic acid scintigraphy was performed at 3 weeks and the animals were sacrificed and examined. Free oxygen radical damage was investigated by measuring malondialdehyde levels in renal tissue. ANOVA and Scheffe's test were used for statistical analysis. RESULTS: Histopathological evaluation of the right kidney from group 2 rabbits showed mild interstitial fibrosis and mononuclear cell infiltration. The right kidney from group 3 rabbits showed apparent periglomerular fibrosis, tubular atrophy and dilatation, severe interstitial scarring and fibrosis with mononuclear cell infiltrate. There were marked histopathological changes in the right kidney of group 3 rabbits. The absolute percent dose uptake was unchanged in group 2 rabbits (p >0.05). There was significantly decreased uptake in refluxing kidneys and increased uptake in the contralateral nonrefluxing kidneys after vesicoureteral reflux in group 3 rabbits. The malondialdehyde level in the right renal tissue of group 3 was significantly higher than that in controls and in group 2 (p <0.05). The malondialdehyde level in the sterile reflux group did not differ significantly from that in the control group (p >0.05). CONCLUSIONS: The results of this study show that free oxygen radical damage in the presence of infection has an important role in reflux nephropathy.

Animals↗
PubMed2002

Idiopathic calcinosis cutis of the vulva in an elderly woman. A case report.

BACKGROUND: Idiopathic calcinosis cutis of the vulva is a rare condition of unknown etiology. Only seven cases have been reported to date, and all of them were in children. We report the first case in an elderly woman. CASE: A 68-year-old woman presented with a labial lesion of unknown etiology. Excisional biopsy was performed, and histopathologic evaluation showed subepidermal calcification. Follow-up biochemical and hormonal analysis and screening tests for collagen vascular diseases revealed normal results. CONCLUSION: After diagnosis of calcinosis cutis, a laboratory workup to rule out abnormalities of calcium and phosphorus metabolism, malignant processes and collagen vascular diseases must be carried out. This approach in the evaluation of calcinosis cutis could lead to diagnosis of the underlying disease at an early stage.

Aged↗
PubMed2002

Low dose ketoconazole therapy and thyroid functions in rats.

To determine whether low dose ketoconazole (KTZ) has antithyroid action, we studied thyroid function tests in the 13 rats treated with KTZ (20 mg/kg twice daily) for thirty days. Serum triiodothyronine and thyroxine levels were decreased (P<0.05) and serum thyroid-stimulating hormone levels were mildly increased (P>0.05) at the end of treatment. Histopathological analysis of the thyroid glands demonstrated an increase in cylindrical cells in study group, but the epithelial cells were mainly cubical in control group. These findings showed that low dose KTZ had antithyroid effect in rats. The responsible mechanisms may be direct effect of the drug on thyroid gland.

Animals↗