Biomedical subjects

Filiz Senocak

Publications and source records attributed to Filiz Senocak.

3 recordsLinked to original sources

PubMed2005

Heart rate variability and autonomic dysfunction in SSPE.

Autonomic nervous system involvement in subacute sclerosing panencephalitis was studied in 29 patients by analysis of heart rate variability and compared with a control group which consisted of 20 age- and sex-matched healthy subjects. Holter recordings for 24 hours were obtained, and all recordings were analyzed using time-domain parameters. The patients with subacute sclerosing panencephalitis were found to have significantly lower values of standard deviation of all normal sinus intervals and triangular index when compared with the control group. Of 23 patients who had regular follow-up, 15 died in a period ranging from 1 to 13 months. Twelve of these patients had heart rate variability parameters lower than normal, but no significant difference was observed between the heart rate variability values of patients who survived or died. Also, there was no association between brain magnetic resonance imaging findings and heart rate variability indices. It is concluded that patients with subacute sclerosing panencephalitis have autonomic dysfunction; and this was thought to be mainly due to central involvement.

Autonomic Nervous System↗

PubMed2003

Tolmetin and salicylate therapy in acute rheumatic fever: Comparison of clinical efficacy and side-effects.

BACKGROUND: The arthritis of rheumatic fever is very responsive to treatment with salicylates, but there are many adverse reactions, especially hepatotoxicity, due to aspirin (acetylsalicylic acid) therapy. These side-effects change the course and duration of rheumatic fever. Other non-steroidal anti-inflammatory drugs may be equally effective, although no reports are available. METHODS: We studied 72 patients with rheumatic fever who were admitted to Dr Sami Ulus Children's Hospital between 1995 and 1999. Twenty patients with arthritis were treated with tolmetin (25 mg/kg per day; group I) and 52 patients with arthritis and/or mild carditis were put on aspirin therapy (75-100 mg/kg per day) for 4-6 weeks (group II). Arthritis had disappeared at the same time in both the aspirin and tolmetin groups (P = 0.675). RESULTS: The erythrocyte sedimentation rates of patients upon admission, at the first week and at the end of therapy were not different in the two groups (P > 0.05). No adverse effect of tolmetin therapy was observed, whereas side-effects of salicylate were observed in 19 patients (36.5%) in the aspirin group. Hepatotoxicity, gastric irritation and salicylism were found in 16, four and three patients, respectively. Renal toxicity and Reye syndrome were not demonstrated. Because of these side-effects of aspirin, therapy had to be stopped for 10-20 days and the duration of hospitalization in this group was lengthened unnecessarily. CONCLUSION: Tolmetin was safe and effective treatment for arthritic rheumatic fever patients without carditis. Tolmetin can be used particularly in patients who cannot tolerate aspirin.

Adolescent↗

PubMedDate not supplied

Cardiovascular changes in children with pneumonia.

Pneumonia is an important cause of death in childhood, especially in the infancy period. Since the respiratory and cardiovascular systems cannot be thought of independently, it is important to detect cardiovascular changes during pneumonia. We prospectively studied 50 children aged 2-24 months admitted to the hospital because of pneumonia in order to evaluate their cardiovascular findings with noninvasive methods. Patients were classified according to the World Health Organization (WHO) criteria of pneumonia, and evaluated by obtaining complete blood counts, serum electrolytes, renal and liver function tests, blood gases, creatinine kinase MB fraction (CK-MB), chest X-ray, electrocardiography (ECG) and echocardiography at the admission and after clinical recovery. Right ventricular systolic pressure (RVSP) was found to be high in 70% of patients and there was a correlation between the severity of the pneumonia and RVSP All patients had normal left ventricular dimensions and functions, but in 68% of them CK-MB was elevated. In these infants, T voltages in D1 derivation showed a significant rise with clinical recovery. Seven cases developed congestive heart failure, and three died. CK-MB was found to be high in all patients who died and in six of seven patients with congestive heart failure. Our findings suggest that myocarditis incidence in children with pneumonia may be higher than previously known. Since myocarditis can be a fatal disease, its detection is important by noninvasive techniques like ECG, echocardiography and cardiac enzyme measurements.

Cardiovascular Diseases↗