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Frédéric Mercier

Publications and source records attributed to Frédéric Mercier.

2 recordsLinked to original sources

Major complications of regional anesthesia in France: The SOS Regional Anesthesia Hotline Service.

BACKGROUND: Several previous surveys have estimated the rate of major complications that occur after regional anesthesia. However, because of the increase in the use of regional anesthesia in recent years and because of the introduction of new techniques, reappraisal of the incidence and the characteristics of major complications is useful. METHODS: All French anesthesiologists were invited to participate in this 10-month prospective survey based on (1) voluntary reporting of major complications related to regional anesthesia occurring during the study period using a telephone hotline service available 24 h a day and managed by three experts, and (2) voluntary reporting of the number and type of regional anesthesia procedures performed using pocket booklets. The service was free of charge for participants. RESULTS: The participants (n = 487) reported 56 major complications in 158,083 regional anesthesia procedures performed (3.5/10,000). Four deaths were reported. Cardiac arrest occurred after spinal anesthesia (n = 10; 2.7/10,000) and posterior lumbar plexus block (n = 1; 80/10,000). Systemic local anesthetic toxicity consisted of seizures only, without cardiac toxicity. Lidocaine spinal anesthesia was associated with more neurologic complications than bupivacaine spinal anesthesia (14.4/10,000 vs. 2.2/10,000). Most neurologic complications were transient. Among 12 that occurred after peripheral nerve blocks, 9 occurred in patients in whom a nerve stimulator had been used. CONCLUSION: This prospective survey based on a free hotline permanent telephone service allowed us to estimate the incidence of major complications related to regional anesthesia and to provide a detailed analysis of these complications.

Acute Disease↗

Synthesis and Solution State Characterization by Gradient-Enhanced 2D Multinuclear NMR Spectroscopy of a Fluorine-Bridged Dimethyltin(IV) Salicylaldoximate Derivative.

The reaction of [(Me(2)Sn)(2)(Me(2)SnO)(ONZOH)(HONZO)(ONZO)] (HONZOH = o-HON=CHC(6)H(4)OH, salicylaldoxime) with ammonium fluoride yields a fluorotris(dimethyltin) disalicylaldoximate complex, compound 4, containing one seven-coordinate and two five-coordinate tin atoms, with a fluoride anion bridging the five-coordinate tin atoms. Though 4 can be obtained in a crystalline form, its crystals are unsuitable for X-ray analysis. Its structure has been completely characterized in solution by 1D (1)H, (13)C, (119)Sn, and (19)F NMR spectra and 2D gradient-assisted (1)H-(119)Sn and (1)H-(13)C HMQC and HMBC NMR spectra. In solution, 4 is involved in an equilibrium with several species. It is shown that the Sn(2)-F-Sn(3) moiety of 4 is the reactive site amenable to nucleophilic substitution with weak nucleophiles like water and methanol. The preservation of the splitting of the (1)J((119/117)Sn(3)-(19)F) coupling but not the (1)J((119/117)Sn(2)-(19)F) coupling evidences a reaction intermediate where the entering nucleophile is bound to the Sn(2) tin atom whereas the fluorine is still linked to the Sn(3) atom. Overall, &mgr;(2)-nucleophilic substitutions on compound 4 with hydroxylated nucleophiles should be viewed as addition-elimination reactions.

Journal Article↗